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Items: 1 to 20 of 115


The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer.

Pound LD, Hang Y, Sarkar SA, Wang Y, Milam LA, Oeser JK, Printz RL, Lee CE, Stein R, Hutton JC, O'Brien RM.

Biochem J. 2011 Jan 1;433(1):95-105. doi: 10.1042/BJ20101488.


Characterization of the human SLC30A8 promoter and intronic enhancer.

Pound LD, Sarkar SA, Cauchi S, Wang Y, Oeser JK, Lee CE, Froguel P, Hutton JC, O'Brien RM.

J Mol Endocrinol. 2011 Sep 30;47(3):251-9. doi: 10.1530/JME-11-0055. Print 2011 Dec.


Interactions between areas I and II direct pdx-1 expression specifically to islet cell types of the mature and developing pancreas.

Van Velkinburgh JC, Samaras SE, Gerrish K, Artner I, Stein R.

J Biol Chem. 2005 Nov 18;280(46):38438-44. Epub 2005 Sep 7.


Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2.

Cissell MA, Zhao L, Sussel L, Henderson E, Stein R.

J Biol Chem. 2003 Jan 10;278(2):751-6. Epub 2002 Nov 7.


The PDX-1 activation domain provides specific functions necessary for transcriptional stimulation in pancreatic beta-cells.

Peshavaria M, Cissell MA, Henderson E, Petersen HV, Stein R.

Mol Endocrinol. 2000 Dec;14(12):1907-17.


Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion.

Pound LD, Sarkar SA, Benninger RK, Wang Y, Suwanichkul A, Shadoan MK, Printz RL, Oeser JK, Lee CE, Piston DW, McGuinness OP, Hutton JC, Powell DR, O'Brien RM.

Biochem J. 2009 Jul 15;421(3):371-6. doi: 10.1042/BJ20090530.


The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription.

Zhao L, Guo M, Matsuoka TA, Hagman DK, Parazzoli SD, Poitout V, Stein R.

J Biol Chem. 2005 Mar 25;280(12):11887-94. Epub 2005 Jan 20.


The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background.

Pound LD, Sarkar SA, Ustione A, Dadi PK, Shadoan MK, Lee CE, Walters JA, Shiota M, McGuinness OP, Jacobson DA, Piston DW, Hutton JC, Powell DR, O'Brien RM.

PLoS One. 2012;7(7):e40972. doi: 10.1371/journal.pone.0040972. Epub 2012 Jul 19.


Identification of a novel PDX-1 binding site in the human insulin gene enhancer.

Le Lay J, Matsuoka TA, Henderson E, Stein R.

J Biol Chem. 2004 May 21;279(21):22228-35. Epub 2004 Mar 16.


Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression.

Martin CC, Flemming BP, Wang Y, Oeser JK, O'Brien RM.

J Mol Endocrinol. 2008 Nov;41(5):315-28. doi: 10.1677/JME-08-0062. Epub 2008 Aug 27.


Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion.

Syring KE, Boortz KA, Oeser JK, Ustione A, Platt KA, Shadoan MK, McGuinness OP, Piston DW, Powell DR, O'Brien RM.

Endocrinology. 2016 Dec;157(12):4534-4541. Epub 2016 Oct 18.


Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene.

Wu KL, Gannon M, Peshavaria M, Offield MF, Henderson E, Ray M, Marks A, Gamer LW, Wright CV, Stein R.

Mol Cell Biol. 1997 Oct;17(10):6002-13.


The role of hepatic nuclear factor 1 alpha and PDX-1 in transcriptional regulation of the pdx-1 gene.

Gerrish K, Cissell MA, Stein R.

J Biol Chem. 2001 Dec 21;276(51):47775-84. Epub 2001 Oct 5.


A pancreatic beta -cell-specific enhancer in the human PDX-1 gene is regulated by hepatocyte nuclear factor 3beta (HNF-3beta ), HNF-1alpha, and SPs transcription factors.

Ben-Shushan E, Marshak S, Shoshkes M, Cerasi E, Melloul D.

J Biol Chem. 2001 May 18;276(20):17533-40. Epub 2001 Feb 5.


Regulatory elements involved in human pdx-1 gene expression.

Marshak S, Ben-Shushan E, Shoshkes M, Havin L, Cerasi E, Melloul D.

Diabetes. 2001 Feb;50 Suppl 1:S37-8.


Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.

Iype T, Francis J, Garmey JC, Schisler JC, Nesher R, Weir GC, Becker TC, Newgard CB, Griffen SC, Mirmira RG.

J Biol Chem. 2005 Apr 29;280(17):16798-807. Epub 2005 Mar 2.


Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta.

Shih DQ, Heimesaat M, Kuwajima S, Stein R, Wright CV, Stoffel M.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3818-23.

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