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Items: 1 to 20 of 109


Other ways to skin a cat: activating SREBP without Scap.

Ozdemir C, Rawson RB.

Fly (Austin). 2011 Jan-Mar;5(1):3-6. Epub 2011 Jan 1.


Activation of sterol regulatory element binding proteins in the absence of Scap in Drosophila melanogaster.

Matthews KA, Ozdemir C, Rawson RB.

Genetics. 2010 May;185(1):189-98. doi: 10.1534/genetics.110.114975. Epub 2010 Feb 22.


Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster.

Matthews KA, Kunte AS, Tambe-Ebot E, Rawson RB.

Genetics. 2009 Jan;181(1):119-28. doi: 10.1534/genetics.108.093450. Epub 2008 Nov 17.


Activation of sterol regulatory element-binding protein by the caspase Drice in Drosophila larvae.

Amarneh B, Matthews KA, Rawson RB.

J Biol Chem. 2009 Apr 10;284(15):9674-82. doi: 10.1074/jbc.M900346200. Epub 2009 Feb 17.


PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus.

Xu D, Wang Z, Zhang Y, Jiang W, Pan Y, Song BL, Chen Y.

Nat Commun. 2015 Aug 27;6:8100. doi: 10.1038/ncomms9100.


Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-binding Protein (SREBP) and SREBP Cleavage-activating Protein.

Kuan YC, Hashidume T, Shibata T, Uchida K, Shimizu M, Inoue J, Sato R.

J Biol Chem. 2017 Feb 17;292(7):3016-3028. doi: 10.1074/jbc.M116.767277. Epub 2016 Dec 21.


Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP).

Shao W, Espenshade PJ.

J Biol Chem. 2014 Mar 14;289(11):7547-57. doi: 10.1074/jbc.M113.545699. Epub 2014 Jan 29.


Fatty acid auxotrophy in Drosophila larvae lacking SREBP.

Kunte AS, Matthews KA, Rawson RB.

Cell Metab. 2006 Jun;3(6):439-48.


Glutamine stimulates the gene expression and processing of sterol regulatory element binding proteins, thereby increasing the expression of their target genes.

Inoue J, Ito Y, Shimada S, Satoh SI, Sasaki T, Hashidume T, Kamoshida Y, Shimizu M, Sato R.

FEBS J. 2011 Aug;278(15):2739-50. doi: 10.1111/j.1742-4658.2011.08204.x. Epub 2011 Jun 22.


Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs.

Dobrosotskaya IY, Goldstein JL, Brown MS, Rawson RB.

J Biol Chem. 2003 Sep 12;278(37):35837-43. Epub 2003 Jul 3.


COPI-mediated retrieval of SCAP is crucial for regulating lipogenesis under basal and sterol-deficient conditions.

Takashima K, Saitoh A, Funabashi T, Hirose S, Yagi C, Nozaki S, Sato R, Shin HW, Nakayama K.

J Cell Sci. 2015 Aug 1;128(15):2805-15. doi: 10.1242/jcs.164137. Epub 2015 Jun 19.


Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis.

Motamed M, Zhang Y, Wang ML, Seemann J, Kwon HJ, Goldstein JL, Brown MS.

J Biol Chem. 2011 May 20;286(20):18002-12. doi: 10.1074/jbc.M111.238311. Epub 2011 Mar 24.


Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila.

Lim HY, Wang W, Wessells RJ, Ocorr K, Bodmer R.

Genes Dev. 2011 Jan 15;25(2):189-200. doi: 10.1101/gad.1992411.


Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner.

Shao W, Machamer CE, Espenshade PJ.

J Lipid Res. 2016 Aug;57(8):1564-73. doi: 10.1194/jlr.M069583. Epub 2016 Jun 20.


Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast.

Cheung R, Espenshade PJ.

J Biol Chem. 2013 Jul 12;288(28):20351-60. doi: 10.1074/jbc.M113.482224. Epub 2013 May 31.


Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP.

Hughes AL, Stewart EV, Espenshade PJ.

J Lipid Res. 2008 Sep;49(9):2001-12. doi: 10.1194/jlr.M800207-JLR200. Epub 2008 May 23.


Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.

Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL, Brown MS.

Cell. 2002 Aug 23;110(4):489-500.


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