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Items: 1 to 20 of 122


Making sense of ubiquitin ligases that regulate p53.

Jain AK, Barton MC.

Cancer Biol Ther. 2010 Oct 1;10(7):665-72. Epub 2010 Oct 1. Review.


Limiting the power of p53 through the ubiquitin proteasome pathway.

Pant V, Lozano G.

Genes Dev. 2014 Aug 15;28(16):1739-51. doi: 10.1101/gad.247452.114. Review.


ATM activates p53 by regulating MDM2 oligomerization and E3 processivity.

Cheng Q, Chen L, Li Z, Lane WS, Chen J.

EMBO J. 2009 Dec 16;28(24):3857-67. doi: 10.1038/emboj.2009.294.


p53 Ubiquitination and proteasomal degradation.

Love IM, Shi D, Grossman SR.

Methods Mol Biol. 2013;962:63-73. doi: 10.1007/978-1-62703-236-0_5.


The p53 paddy wagon: COP1, Pirh2 and MDM2 are found resisting apoptosis and growth arrest.

Corcoran CA, Huang Y, Sheikh MS.

Cancer Biol Ther. 2004 Aug;3(8):721-5. Epub 2004 Aug 1.


C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.

Carter S, Bischof O, Dejean A, Vousden KH.

Nat Cell Biol. 2007 Apr;9(4):428-35. Epub 2007 Mar 18.


p53 regulation by ubiquitin.

Brooks CL, Gu W.

FEBS Lett. 2011 Sep 16;585(18):2803-9. doi: 10.1016/j.febslet.2011.05.022. Epub 2011 May 27. Review.


Essential Roles of E3 Ubiquitin Ligases in p53 Regulation.

Sane S, Rezvani K.

Int J Mol Sci. 2017 Feb 17;18(2). pii: E442. doi: 10.3390/ijms18020442. Review.


A portrayal of E3 ubiquitin ligases and deubiquitylases in cancer.

Satija YK, Bhardwaj A, Das S.

Int J Cancer. 2013 Dec 15;133(12):2759-68. doi: 10.1002/ijc.28129. Epub 2013 Mar 25. Review.


HECT and RING finger families of E3 ubiquitin ligases at a glance.

Metzger MB, Hristova VA, Weissman AM.

J Cell Sci. 2012 Feb 1;125(Pt 3):531-7. doi: 10.1242/jcs.091777. Review. No abstract available.


p53 ubiquitination: Mdm2 and beyond.

Brooks CL, Gu W.

Mol Cell. 2006 Feb 3;21(3):307-15. Review.


Regulation of p53 by Mdm2: fate is in the numbers.

Shmueli A, Oren M.

Mol Cell. 2004 Jan 16;13(1):4-5.


Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.

Nie J, Xie P, Liu L, Xing G, Chang Z, Yin Y, Tian C, He F, Zhang L.

J Biol Chem. 2010 Jul 23;285(30):22818-30. doi: 10.1074/jbc.M110.126920. Epub 2010 May 18.


MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.

Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Zhang Y, Pledger JW, Chen J, Bai W.

J Biol Chem. 2009 May 22;284(21):13987-4000. doi: 10.1074/jbc.M901758200. Epub 2009 Mar 25.


Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms.

de Bie P, Ciechanover A.

Cell Death Differ. 2011 Sep;18(9):1393-402. doi: 10.1038/cdd.2011.16. Epub 2011 Mar 4. Review.


Dynamics in the p53-Mdm2 ubiquitination pathway.

Brooks CL, Gu W.

Cell Cycle. 2004 Jul;3(7):895-9. Epub 2004 Jul 2. Review.


Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism.

Dai MS, Shi D, Jin Y, Sun XX, Zhang Y, Grossman SR, Lu H.

J Biol Chem. 2006 Aug 25;281(34):24304-13. Epub 2006 Jun 27.


The multiple levels of regulation by p53 ubiquitination.

Lee JT, Gu W.

Cell Death Differ. 2010 Jan;17(1):86-92. doi: 10.1038/cdd.2009.77. Review.


Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.

Rajendra R, Malegaonkar D, Pungaliya P, Marshall H, Rasheed Z, Brownell J, Liu LF, Lutzker S, Saleem A, Rubin EH.

J Biol Chem. 2004 Aug 27;279(35):36440-4. Epub 2004 Jul 9.


Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms.

Stad R, Little NA, Xirodimas DP, Frenk R, van der Eb AJ, Lane DP, Saville MK, Jochemsen AG.

EMBO Rep. 2001 Nov;2(11):1029-34. Epub 2001 Oct 17.

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