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Downregulation of autophagy by Bcl-2 promotes MCF7 breast cancer cell growth independent of its inhibition of apoptosis.

Oh S, Xiaofei E, Ni D, Pirooz SD, Lee JY, Lee D, Zhao Z, Lee S, Lee H, Ku B, Kowalik T, Martin SE, Oh BH, Jung JU, Liang C.

Cell Death Differ. 2011 Mar;18(3):452-64. doi: 10.1038/cdd.2010.116. Epub 2010 Oct 1.


Apogossypolone induces autophagy and apoptosis in breast cancer MCF-7 cells in vitro and in vivo.

Niu X, Li S, Wei F, Huang J, Wu G, Xu L, Xu D, Wang S.

Breast Cancer. 2014 Mar;21(2):223-30. doi: 10.1007/s12282-012-0372-z. Epub 2012 Jun 19.


A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum.

Lian J, Wu X, He F, Karnak D, Tang W, Meng Y, Xiang D, Ji M, Lawrence TS, Xu L.

Cell Death Differ. 2011 Jan;18(1):60-71. doi: 10.1038/cdd.2010.74. Epub 2010 Jun 25.


Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro.

Zhou L, Wang HF, Ren HG, Chen D, Gao F, Hu QS, Fu C, Xu RJ, Ying Z, Wang GH.

Acta Pharmacol Sin. 2013 May;34(5):651-6. doi: 10.1038/aps.2013.12. Epub 2013 Apr 8.


The significance of expression of autophagy-related gene Beclin, Bcl-2, and Bax in breast cancer tissues.

Yao Q, Chen J, Lv Y, Wang T, Zhang J, Fan J, Wang L.

Tumour Biol. 2011 Dec;32(6):1163-71. doi: 10.1007/s13277-011-0219-9. Epub 2011 Aug 23.


Targeting γ-herpesvirus 68 Bcl-2-mediated down-regulation of autophagy.

Su M, Mei Y, Sanishvili R, Levine B, Colbert CL, Sinha S.

J Biol Chem. 2014 Mar 21;289(12):8029-40. doi: 10.1074/jbc.M113.515361. Epub 2014 Jan 17.


Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.

Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH, Jung JU.

Nat Cell Biol. 2006 Jul;8(7):688-99. Epub 2006 Jun 25.


Bcl-2 down-regulation by small interfering RNA induces Beclin1-dependent autophagy in human SGC-7901 cells.

Du Y, Ji X.

Cell Biol Int. 2014 Oct;38(10):1155-62. doi: 10.1002/cbin.10333. Epub 2014 Jul 15.


Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent.

Parkhitko A, Myachina F, Morrison TA, Hindi KM, Auricchio N, Karbowniczek M, Wu JJ, Finkel T, Kwiatkowski DJ, Yu JJ, Henske EP.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12455-60. doi: 10.1073/pnas.1104361108. Epub 2011 Jul 11.


Ras-related tumorigenesis is suppressed by BNIP3-mediated autophagy through inhibition of cell proliferation.

Wu SY, Lan SH, Cheng DE, Chen WK, Shen CH, Lee YR, Zuchini R, Liu HS.

Neoplasia. 2011 Dec;13(12):1171-82.


Removal of the BH4 domain from Bcl-2 protein triggers an autophagic process that impairs tumor growth.

Trisciuoglio D, De Luca T, Desideri M, Passeri D, Gabellini C, Scarpino S, Liang C, Orlandi A, Del Bufalo D.

Neoplasia. 2013 Mar;15(3):315-27.


Autophagy blockade sensitizes the anticancer activity of CA-4 via JNK-Bcl-2 pathway.

Li Y, Luo P, Wang J, Dai J, Yang X, Wu H, Yang B, He Q.

Toxicol Appl Pharmacol. 2014 Jan 15;274(2):319-27. doi: 10.1016/j.taap.2013.11.018. Epub 2013 Dec 7.


MiR-16 targets Bcl-2 in paclitaxel-resistant lung cancer cells and overexpression of miR-16 along with miR-17 causes unprecedented sensitivity by simultaneously modulating autophagy and apoptosis.

Chatterjee A, Chattopadhyay D, Chakrabarti G.

Cell Signal. 2015 Feb;27(2):189-203. doi: 10.1016/j.cellsig.2014.11.023. Epub 2014 Nov 27.


Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells.

Cheng X, Liu H, Jiang CC, Fang L, Chen C, Zhang XD, Jiang ZW.

Int J Mol Med. 2014 Sep;34(3):772-81. doi: 10.3892/ijmm.2014.1822. Epub 2014 Jun 25.


1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.

Vanderlaag K, Su Y, Frankel AE, Burghardt RC, Barhoumi R, Chadalapaka G, Jutooru I, Safe S.

BMC Cancer. 2010 Dec 3;10:669. doi: 10.1186/1471-2407-10-669.


CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2.

Liu K, Shi Y, Guo X, Wang S, Ouyang Y, Hao M, Liu D, Qiao L, Li N, Zheng J, Chen D.

Cell Death Dis. 2014 Jul 17;5:e1323. doi: 10.1038/cddis.2014.276.


Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2.

Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Ivessa A, Sciarretta S, Del Re DP, Zablocki DK, Hsu CP, Lim DS, Isobe M, Sadoshima J.

Nat Med. 2013 Nov;19(11):1478-88. doi: 10.1038/nm.3322. Epub 2013 Oct 20.


Induction of autophagy and inhibition of tumorigenesis by beclin 1.

Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B.

Nature. 1999 Dec 9;402(6762):672-6.


Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.

Chen S, Zhou L, Zhang Y, Leng Y, Pei XY, Lin H, Jones R, Orlowski RZ, Dai Y, Grant S.

Mol Cell Biol. 2014 Sep 15;34(18):3435-49. doi: 10.1128/MCB.01383-13. Epub 2014 Jul 7.

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