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Items: 1 to 20 of 102

1.

Tau reduction prevents Abeta-induced defects in axonal transport.

Vossel KA, Zhang K, Brodbeck J, Daub AC, Sharma P, Finkbeiner S, Cui B, Mucke L.

Science. 2010 Oct 8;330(6001):198. doi: 10.1126/science.1194653. Epub 2010 Sep 9.

2.

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.

Vossel KA, Xu JC, Fomenko V, Miyamoto T, Suberbielle E, Knox JA, Ho K, Kim DH, Yu GQ, Mucke L.

J Cell Biol. 2015 May 11;209(3):419-33. doi: 10.1083/jcb.201407065.

3.

Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines.

Zempel H, Thies E, Mandelkow E, Mandelkow EM.

J Neurosci. 2010 Sep 8;30(36):11938-50. doi: 10.1523/JNEUROSCI.2357-10.2010. Erratum in: J Neurosci. 2012 Apr 25;32(17):6052.

4.

Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons.

Umeda T, Ramser EM, Yamashita M, Nakajima K, Mori H, Silverman MA, Tomiyama T.

Acta Neuropathol Commun. 2015 Aug 21;3:51. doi: 10.1186/s40478-015-0230-2. Erratum in: Acta Neuropathol Commun. 2016;4:7.

5.

Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons.

Ramser EM, Gan KJ, Decker H, Fan EY, Suzuki MM, Ferreira ST, Silverman MA.

Mol Biol Cell. 2013 Aug;24(16):2494-505. doi: 10.1091/mbc.E12-12-0858. Epub 2013 Jun 19.

6.

Linking amyloid-β and tau: amyloid-β induced synaptic dysfunction via local wreckage of the neuronal cytoskeleton.

Zempel H, Mandelkow EM.

Neurodegener Dis. 2012;10(1-4):64-72. doi: 10.1159/000332816. Epub 2011 Dec 7.

PMID:
22156588
7.

Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease.

Reddy PH.

Brain Res. 2011 Sep 30;1415:136-48. doi: 10.1016/j.brainres.2011.07.052. Epub 2011 Jul 31. Review.

8.

Modulation of insulin signaling rescues BDNF transport defects independent of tau in amyloid-β oligomer-treated hippocampal neurons.

Takach O, Gill TB, Silverman MA.

Neurobiol Aging. 2015 Mar;36(3):1378-82. doi: 10.1016/j.neurobiolaging.2014.11.018. Epub 2014 Dec 3.

PMID:
25543463
9.

Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons.

Calkins MJ, Reddy PH.

Biochim Biophys Acta. 2011 Apr;1812(4):507-13. doi: 10.1016/j.bbadis.2011.01.007. Epub 2011 Jan 15.

10.

Tau facilitates Aβ-induced loss of mitochondrial membrane potential independent of cytosolic calcium fluxes in mouse cortical neurons.

Pallo SP, Johnson GV.

Neurosci Lett. 2015 Jun 15;597:32-7. doi: 10.1016/j.neulet.2015.04.021. Epub 2015 Apr 15.

11.

Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.

Ma QL, Yang F, Rosario ER, Ubeda OJ, Beech W, Gant DJ, Chen PP, Hudspeth B, Chen C, Zhao Y, Vinters HV, Frautschy SA, Cole GM.

J Neurosci. 2009 Jul 15;29(28):9078-89. doi: 10.1523/JNEUROSCI.1071-09.2009.

12.

Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.

Shipton OA, Leitz JR, Dworzak J, Acton CE, Tunbridge EM, Denk F, Dawson HN, Vitek MP, Wade-Martins R, Paulsen O, Vargas-Caballero M.

J Neurosci. 2011 Feb 2;31(5):1688-92. doi: 10.1523/JNEUROSCI.2610-10.2011.

13.

Examination of potential mechanisms of amyloid-induced defects in neuronal transport.

Shah SB, Nolan R, Davis E, Stokin GB, Niesman I, Canto I, Glabe C, Goldstein LS.

Neurobiol Dis. 2009 Oct;36(1):11-25. doi: 10.1016/j.nbd.2009.05.016. Epub 2009 Jun 1.

PMID:
19497367
14.

Imaging organelle transport in primary hippocampal neurons treated with amyloid-β oligomers.

Gan KJ, Silverman MA.

Methods Cell Biol. 2016;131:425-51. doi: 10.1016/bs.mcb.2015.06.012. Epub 2015 Sep 2.

PMID:
26794527
15.

The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons.

Sinjoanu RC, Kleinschmidt S, Bitner RS, Brioni JD, Moeller A, Ferreira A.

Neurochem Int. 2008 Sep;53(3-4):79-88. doi: 10.1016/j.neuint.2008.06.003. Epub 2008 Jun 12.

16.

Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells.

Zeng KW, Ko H, Yang HO, Wang XM.

Neuropharmacology. 2010 Nov;59(6):542-50. doi: 10.1016/j.neuropharm.2010.07.020. Epub 2010 Aug 12.

PMID:
20708632
18.

Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers.

Tang Y, Scott DA, Das U, Edland SD, Radomski K, Koo EH, Roy S.

Traffic. 2012 May;13(5):681-93. doi: 10.1111/j.1600-0854.2012.01340.x. Epub 2012 Feb 27.

19.

Abeta, tau and ApoE4 in Alzheimer's disease: the axonal connection.

Adalbert R, Gilley J, Coleman MP.

Trends Mol Med. 2007 Apr;13(4):135-42. Epub 2007 Mar 6.

PMID:
17344096
20.

Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific.

Zago W, Buttini M, Comery TA, Nishioka C, Gardai SJ, Seubert P, Games D, Bard F, Schenk D, Kinney GG.

J Neurosci. 2012 Feb 22;32(8):2696-702. doi: 10.1523/JNEUROSCI.1676-11.2012.

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