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Items: 1 to 20 of 98

1.

Small molecule inhibitors of DNA repair nuclease activities of APE1.

Wilson DM 3rd, Simeonov A.

Cell Mol Life Sci. 2010 Nov;67(21):3621-31. doi: 10.1007/s00018-010-0488-2. Epub 2010 Aug 31. Review.

2.

Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1).

Laev SS, Salakhutdinov NF, Lavrik OI.

Bioorg Med Chem. 2017 May 1;25(9):2531-2544. doi: 10.1016/j.bmc.2017.01.028. Epub 2017 Jan 21. Review.

PMID:
28161249
3.

Small-molecule inhibitors of APE1 DNA repair function: an overview.

Al-Safi RI, Odde S, Shabaik Y, Neamati N.

Curr Mol Pharmacol. 2012 Jan;5(1):14-35. Review.

PMID:
22122462
4.

Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitors.

Zawahir Z, Dayam R, Deng J, Pereira C, Neamati N.

J Med Chem. 2009 Jan 8;52(1):20-32. doi: 10.1021/jm800739m.

PMID:
19072053
5.

Isolation of a small molecule inhibitor of DNA base excision repair.

Madhusudan S, Smart F, Shrimpton P, Parsons JL, Gardiner L, Houlbrook S, Talbot DC, Hammonds T, Freemont PA, Sternberg MJ, Dianov GL, Hickson ID.

Nucleic Acids Res. 2005 Aug 19;33(15):4711-24. Print 2005.

6.

Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection.

Dorjsuren D, Kim D, Vyjayanti VN, Maloney DJ, Jadhav A, Wilson DM 3rd, Simeonov A.

PLoS One. 2012;7(10):e47974. doi: 10.1371/journal.pone.0047974. Epub 2012 Oct 23.

7.

Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.

Bapat A, Glass LS, Luo M, Fishel ML, Long EC, Georgiadis MM, Kelley MR.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):988-98. doi: 10.1124/jpet.110.169128. Epub 2010 May 26.

8.

NMR studies reveal an unexpected binding site for a redox inhibitor of AP endonuclease 1.

Manvilla BA, Wauchope O, Seley-Radtke KL, Drohat AC.

Biochemistry. 2011 Dec 6;50(48):10540-9. doi: 10.1021/bi201071g. Epub 2011 Nov 9.

9.

Receptor-based virtual screening and biological characterization of human apurinic/apyrimidinic endonuclease (Ape1) inhibitors.

Ruiz FM, Francis SM, Tintoré M, Ferreira R, Gil-Redondo R, Morreale A, Ortiz ÁR, Eritja R, Fàbrega C.

ChemMedChem. 2012 Dec;7(12):2168-78. doi: 10.1002/cmdc.201200372. Epub 2012 Oct 25.

11.

Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines.

Mohammed MZ, Vyjayanti VN, Laughton CA, Dekker LV, Fischer PM, Wilson DM 3rd, Abbotts R, Shah S, Patel PM, Hickson ID, Madhusudan S.

Br J Cancer. 2011 Feb 15;104(4):653-63. doi: 10.1038/sj.bjc.6606058. Epub 2011 Jan 25.

12.

New oligonucleotide derivatives as unreactive substrate analogues and potential inhibitors of human apurinic/apyrimidinic endonuclease APE1.

Kuznetsov NA, Kupryushkin MS, Abramova TV, Kuznetsova AA, Miroshnikova AD, Stetsenko DA, Pyshnyi DV, Fedorova OS.

Mol Biosyst. 2016 Jan;12(1):67-75. doi: 10.1039/c5mb00692a.

PMID:
26548492
13.

Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.

Sultana R, McNeill DR, Abbotts R, Mohammed MZ, Zdzienicka MZ, Qutob H, Seedhouse C, Laughton CA, Fischer PM, Patel PM, Wilson DM 3rd, Madhusudan S.

Int J Cancer. 2012 Nov 15;131(10):2433-44. doi: 10.1002/ijc.27512. Epub 2012 Mar 28.

14.

Distinct roles of Ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin.

Fung H, Demple B.

J Biol Chem. 2011 Feb 18;286(7):4968-77. doi: 10.1074/jbc.M110.146498. Epub 2010 Nov 15.

15.

Structure-based virtual screening toward the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1.

Guerreiro PS, Estácio SG, Antunes F, Fernandes AS, Pinheiro PF, Costa JG, Castro M, Miranda JP, Guedes RC, Oliveira NG.

Chem Biol Drug Des. 2016 Dec;88(6):915-925. doi: 10.1111/cbdd.12826. Epub 2016 Sep 16.

PMID:
27450574
16.

Design and synthesis of 3-carbamoylbenzoic acid derivatives as inhibitors of human apurinic/apyrimidinic endonuclease 1 (APE1).

Aiello F, Shabaik Y, Esqueda A, Sanchez TW, Grande F, Garofalo A, Neamati N.

ChemMedChem. 2012 Oct;7(10):1825-39. doi: 10.1002/cmdc.201200334. Epub 2012 Sep 5.

PMID:
22952012
17.

Human apurinic/apyrimidinic endonuclease 1.

Li M, Wilson DM 3rd.

Antioxid Redox Signal. 2014 Feb 1;20(4):678-707. doi: 10.1089/ars.2013.5492. Epub 2013 Aug 20. Review.

18.

Human AP endonuclease 1 (APE1): from mechanistic insights to druggable target in cancer.

Abbotts R, Madhusudan S.

Cancer Treat Rev. 2010 Aug;36(5):425-35. doi: 10.1016/j.ctrv.2009.12.006. Epub 2010 Jan 6. Review.

PMID:
20056333
19.

Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment.

Tell G, Fantini D, Quadrifoglio F.

Cell Mol Life Sci. 2010 Nov;67(21):3589-608. doi: 10.1007/s00018-010-0486-4. Epub 2010 Aug 13. Review.

PMID:
20706766
20.

Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1.

Simeonov A, Kulkarni A, Dorjsuren D, Jadhav A, Shen M, McNeill DR, Austin CP, Wilson DM 3rd.

PLoS One. 2009 Jun 1;4(6):e5740. doi: 10.1371/journal.pone.0005740.

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