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Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.

Ribeiro PS, Josué F, Wepf A, Wehr MC, Rinner O, Kelly G, Tapon N, Gstaiger M.

Mol Cell. 2010 Aug 27;39(4):521-34. doi: 10.1016/j.molcel.2010.08.002.


Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila.

Wei X, Shimizu T, Lai ZC.

EMBO J. 2007 Apr 4;26(7):1772-81. Epub 2007 Mar 8.


Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines.

Zhang X, Milton CC, Humbert PO, Harvey KF.

Cancer Res. 2009 Aug 1;69(15):6033-41. doi: 10.1158/0008-5472.CAN-08-4592. Epub 2009 Jul 7.


Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage.

Colombani J, Polesello C, Josué F, Tapon N.

Curr Biol. 2006 Jul 25;16(14):1453-8.


The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway.

Yue T, Tian A, Jiang J.

Dev Cell. 2012 Feb 14;22(2):255-67. doi: 10.1016/j.devcel.2011.12.011. Epub 2012 Jan 25.


Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch.

Polesello C, Tapon N.

Curr Biol. 2007 Nov 6;17(21):1864-70. Epub 2007 Oct 25. Erratum in: Curr Biol. 2007 Nov 20;17(22):2001.


Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.

Wehr MC, Holder MV, Gailite I, Saunders RE, Maile TM, Ciirdaeva E, Instrell R, Jiang M, Howell M, Rossner MJ, Tapon N.

Nat Cell Biol. 2013 Jan;15(1):61-71.


The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.

Pantalacci S, Tapon N, Léopold P.

Nat Cell Biol. 2003 Oct;5(10):921-7. Epub 2003 Sep 21.


Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila.

Ye X, Deng Y, Lai ZC.

Dev Biol. 2012 Sep 1;369(1):115-23. doi: 10.1016/j.ydbio.2012.06.014. Epub 2012 Jun 23.


Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway.

Udan RS, Kango-Singh M, Nolo R, Tao C, Halder G.

Nat Cell Biol. 2003 Oct;5(10):914-20. Epub 2003 Sep 21.


Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila.

Ho LL, Wei X, Shimizu T, Lai ZC.

Dev Biol. 2010 Jan 15;337(2):274-83. doi: 10.1016/j.ydbio.2009.10.042. Epub 2009 Nov 12.


The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie.

Badouel C, Gardano L, Amin N, Garg A, Rosenfeld R, Le Bihan T, McNeill H.

Dev Cell. 2009 Mar;16(3):411-20. doi: 10.1016/j.devcel.2009.01.010.


Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system.

Gailite I, Aerne BL, Tapon N.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5169-78. doi: 10.1073/pnas.1505512112. Epub 2015 Aug 31.


The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals.

Zeng Q, Hong W.

Cancer Cell. 2008 Mar;13(3):188-92. doi: 10.1016/j.ccr.2008.02.011. Review.


Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.

Grzeschik NA, Parsons LM, Allott ML, Harvey KF, Richardson HE.

Curr Biol. 2010 Apr 13;20(7):573-81. doi: 10.1016/j.cub.2010.01.055. Epub 2010 Apr 1.


CYLD negatively regulates Hippo signaling by limiting Hpo phosphorylation in Drosophila.

Chen Y, Wang Z, Wang P, Li D, Zhou J, Wu S.

Biochem Biophys Res Commun. 2014 Sep 26;452(3):808-12. doi: 10.1016/j.bbrc.2014.09.005. Epub 2014 Sep 6.


The Drosophila RASSF homolog antagonizes the hippo pathway.

Polesello C, Huelsmann S, Brown NH, Tapon N.

Curr Biol. 2006 Dec 19;16(24):2459-65.

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