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Th2-specific immunity and function of peripheral T cells is regulated by the p56Lck Src homology 3 domain.

McCoy ME, Finkelman FD, Straus DB.

J Immunol. 2010 Sep 15;185(6):3285-94. doi: 10.4049/jimmunol.0900027. Epub 2010 Aug 20.


Deficient expression of p56(lck) in Th2 cells leads to partial TCR signaling and a dysregulation in lymphokine mRNA levels.

al-Ramadi BK, Nakamura T, Leitenberg D, Bothwell AL.

J Immunol. 1996 Dec 1;157(11):4751-61.


Requirement for p56(lck) tyrosine kinase activation in Th subset differentiation.

Yamashita M, Hashimoto K, Kimura M, Kubo M, Tada T, Nakayama T.

Int Immunol. 1998 May;10(5):577-91.


Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response.

Lovatt M, Filby A, Parravicini V, Werlen G, Palmer E, Zamoyska R.

Mol Cell Biol. 2006 Nov;26(22):8655-65. Epub 2006 Sep 11.


The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1.

Li M, Ong SS, Rajwa B, Thieu VT, Geahlen RL, Harrison ML.

Mol Cell Biol. 2008 Jan;28(2):630-41. Epub 2007 Nov 12.


Nippostrongylus brasiliensis can induce B7-independent antigen-specific development of IL-4-producing T cells from naive CD4 T cells in vivo.

Liu Z, Liu Q, Pesce J, Whitmire J, Ekkens MJ, Foster A, VanNoy J, Sharpe AH, Urban JF Jr, Gause WC.

J Immunol. 2002 Dec 15;169(12):6959-68.


Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes.

Sohn SJ, Forbush KA, Pan XC, Perlmutter RM.

J Immunol. 2001 Feb 15;166(4):2209-17.


The role of p56lck in the development of gamma delta T cells and their function during an infection by Listeria monocytogenes.

Fujise S, Matsuzaki G, Kishihara K, Kadena T, Molina T, Nomoto K.

J Immunol. 1996 Jul 1;157(1):247-54.


JNK1 is required for T cell-mediated immunity against Leishmania major infection.

Constant SL, Dong C, Yang DD, Wysk M, Davis RJ, Flavell RA.

J Immunol. 2000 Sep 1;165(5):2671-6.


Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation.

Na SY, Patra A, Scheuring Y, Marx A, Tolaini M, Kioussis D, Hemmings BA, Hünig T, Bommhardt U.

J Immunol. 2003 Aug 1;171(3):1285-96. Erratum in: J Immunol. 2006 Feb 15;176(4):2669. Hemmings, Brian [corrected to Hemmings, Brian A].


Dendritic cell-intrinsic expression of NF-kappa B1 is required to promote optimal Th2 cell differentiation.

Artis D, Kane CM, Fiore J, Zaph C, Shapira S, Joyce K, Macdonald A, Hunter C, Scott P, Pearce EJ.

J Immunol. 2005 Jun 1;174(11):7154-9.


Active Ca2+/calmodulin-dependent protein kinase II gamma B impairs positive selection of T cells by modulating TCR signaling.

McGargill MA, Sharp LL, Bui JD, Hedrick SM, Calbo S.

J Immunol. 2005 Jul 15;175(2):656-64.


Complement regulatory protein Crry/p65-mediated signaling in T lymphocytes: role of its cytoplasmic domain and partitioning into lipid rafts.

Jiménez-Periañez A, Ojeda G, Criado G, Sánchez A, Pini E, Madrenas J, Rojo JM, Portolés P.

J Leukoc Biol. 2005 Dec;78(6):1386-96. Epub 2005 Nov 21.


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