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Items: 1 to 20 of 127


Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning.

Ahn Y, Sanderson BW, Klein OD, Krumlauf R.

Development. 2010 Oct;137(19):3221-31. doi: 10.1242/dev.054668. Epub 2010 Aug 19.


Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth.

Cho SW, Kwak S, Woolley TE, Lee MJ, Kim EJ, Baker RE, Kim HJ, Shin JS, Tickle C, Maini PK, Jung HS.

Development. 2011 May;138(9):1807-16. doi: 10.1242/dev.056051. Epub 2011 Mar 29.


Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling.

Ahn Y, Sims C, Logue JM, Weatherbee SD, Krumlauf R.

Development. 2013 Feb 1;140(3):583-93. doi: 10.1242/dev.085118.


Multiple modes of Lrp4 function in modulation of Wnt/β-catenin signaling during tooth development.

Ahn Y, Sims C, Murray MJ, Kuhlmann PK, Fuentes-Antrás J, Weatherbee SD, Krumlauf R.

Development. 2017 Aug 1;144(15):2824-2836. doi: 10.1242/dev.150680. Epub 2017 Jul 10.


Wnt signaling in the murine diastema.

Porntaveetus T, Ohazama A, Choi HY, Herz J, Sharpe PT.

Eur J Orthod. 2012 Aug;34(4):518-24. doi: 10.1093/ejo/cjr049. Epub 2011 Apr 29.


Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.

Ellies DL, Viviano B, McCarthy J, Rey JP, Itasaki N, Saunders S, Krumlauf R.

J Bone Miner Res. 2006 Nov;21(11):1738-49.


Characterization of wise protein and its molecular mechanism to interact with both Wnt and BMP signals.

Lintern KB, Guidato S, Rowe A, Saldanha JW, Itasaki N.

J Biol Chem. 2009 Aug 21;284(34):23159-68. doi: 10.1074/jbc.M109.025478. Epub 2009 Jun 24.


Lrp4 modulates extracellular integration of cell signaling pathways in development.

Ohazama A, Johnson EB, Ota MS, Choi HY, Porntaveetus T, Oommen S, Itoh N, Eto K, Gritli-Linde A, Herz J, Sharpe PT.

PLoS One. 2008;3(12):e4092. doi: 10.1371/journal.pone.0004092. Epub 2008 Dec 31. Erratum in: PLoS ONE. 2009;4(1). doi: 10.1371/annotation/f19bff3b-227a-4159-b166-7dc3c19bec43. Choi, Hong J [corrected to Choi, Hong Y].


A BMP-Shh negative-feedback loop restricts Shh expression during limb development.

Bastida MF, Sheth R, Ros MA.

Development. 2009 Nov;136(22):3779-89. doi: 10.1242/dev.036418.


Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells.

Lu W, Liu CC, Thottassery JV, Bu G, Li Y.

Biochemistry. 2010 Jun 8;49(22):4635-43. doi: 10.1021/bi1001486.


FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice.

Kratochwil K, Galceran J, Tontsch S, Roth W, Grosschedl R.

Genes Dev. 2002 Dec 15;16(24):3173-85.


An inductive signalling network regulates mammalian tooth morphogenesis with implications for tooth regeneration.

Li Z, Yu M, Tian W.

Cell Prolif. 2013 Oct;46(5):501-8. doi: 10.1111/cpr.12051. Epub 2013 Aug 17. Review.


Molecular patterning of the mammalian dentition.

Lan Y, Jia S, Jiang R.

Semin Cell Dev Biol. 2014 Jan-Feb;25-26:61-70. doi: 10.1016/j.semcdb.2013.12.003. Epub 2013 Dec 16. Review.


Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner.

Collette NM, Yee CS, Murugesh D, Sebastian A, Taher L, Gale NW, Economides AN, Harland RM, Loots GG.

Dev Biol. 2013 Nov 1;383(1):90-105. doi: 10.1016/j.ydbio.2013.08.015. Epub 2013 Aug 29.


Functional interactions between the LRP6 WNT co-receptor and folate supplementation.

Gray JD, Nakouzi G, Slowinska-Castaldo B, Dazard JE, Rao JS, Nadeau JH, Ross ME.

Hum Mol Genet. 2010 Dec 1;19(23):4560-72. doi: 10.1093/hmg/ddq384. Epub 2010 Sep 15.


The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice.

Kelly OG, Pinson KI, Skarnes WC.

Development. 2004 Jun;131(12):2803-15. Epub 2004 May 13.


Disrupted dorsal neural tube BMP signaling in the cilia mutant Arl13b hnn stems from abnormal Shh signaling.

Horner VL, Caspary T.

Dev Biol. 2011 Jul 1;355(1):43-54. doi: 10.1016/j.ydbio.2011.04.019. Epub 2011 Apr 22.


Wise regulates bone deposition through genetic interactions with Lrp5.

Ellies DL, Economou A, Viviano B, Rey JP, Paine-Saunders S, Krumlauf R, Saunders S.

PLoS One. 2014 May 1;9(5):e96257. doi: 10.1371/journal.pone.0096257. eCollection 2014. Erratum in: PLoS One. 2014;9(7):e104467.


Epiprofin/Sp6 regulates Wnt-BMP signaling and the establishment of cellular junctions during the bell stage of tooth development.

Ibarretxe G, Aurrekoetxea M, Crende O, Badiola I, Jimenez-Rojo L, Nakamura T, Yamada Y, Unda F.

Cell Tissue Res. 2012 Oct;350(1):95-107. doi: 10.1007/s00441-012-1459-8. Epub 2012 Aug 7.


Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone.

Williams BO, Insogna KL.

J Bone Miner Res. 2009 Feb;24(2):171-8. doi: 10.1359/jbmr.081235. Review.

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