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A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells.

Arias-Romero LE, Villamar-Cruz O, Pacheco A, Kosoff R, Huang M, Muthuswamy SK, Chernoff J.

Oncogene. 2010 Oct 28;29(43):5839-49. doi: 10.1038/onc.2010.318. Epub 2010 Aug 16.


p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target?

Arias-Romero LE, Chernoff J.

Small GTPases. 2010 Sep;1(2):124-128.


Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells.

Arias-Romero LE, Villamar-Cruz O, Huang M, Hoeflich KP, Chernoff J.

Cancer Res. 2013 Jun 15;73(12):3671-82. doi: 10.1158/0008-5472.CAN-12-4453. Epub 2013 Apr 10.


PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling.

Shrestha Y, Schafer EJ, Boehm JS, Thomas SR, He F, Du J, Wang S, Barretina J, Weir BA, Zhao JJ, Polyak K, Golub TR, Beroukhim R, Hahn WC.

Oncogene. 2012 Jul 19;31(29):3397-408. doi: 10.1038/onc.2011.515. Epub 2011 Nov 21.


Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells.

Aksamitiene E, Achanta S, Kolch W, Kholodenko BN, Hoek JB, Kiyatkin A.

Cell Signal. 2011 Nov;23(11):1794-805. doi: 10.1016/j.cellsig.2011.06.014. Epub 2011 Jun 25.


Heregulin-mediated ErbB2-ERK signaling activates hyaluronan synthases leading to CD44-dependent ovarian tumor cell growth and migration.

Bourguignon LY, Gilad E, Peyrollier K.

J Biol Chem. 2007 Jul 6;282(27):19426-41. Epub 2007 May 10.


VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer.

Fernández IF, Blanco S, Lozano J, Lazo PA.

Mol Cell Biol. 2010 Oct;30(19):4687-97. doi: 10.1128/MCB.01581-09. Epub 2010 Aug 2.


Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling.

Tabusa H, Brooks T, Massey AJ.

Mol Cancer Res. 2013 Feb;11(2):109-21. doi: 10.1158/1541-7786.MCR-12-0466. Epub 2012 Dec 10.


TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation.

Oberst MD, Beberman SJ, Zhao L, Yin JJ, Ward Y, Kelly K.

BMC Cancer. 2008 Jul 2;8:189. doi: 10.1186/1471-2407-8-189.


Mediator of ERBB2-driven cell motility (MEMO) promotes extranuclear estrogen receptor signaling involving the growth factor receptors IGF1R and ERBB2.

Jiang K, Yang Z, Cheng L, Wang S, Ning K, Zhou L, Lin J, Zhong H, Wang L, Li Y, Huang J, Zhang H, Ye Q.

J Biol Chem. 2013 Aug 23;288(34):24590-9. doi: 10.1074/jbc.M113.467837. Epub 2013 Jul 16.


Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.

McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand FE, Navolanic PM, Terrian DM, Franklin RA, D'Assoro AB, Salisbury JL, Mazzarino MC, Stivala F, Libra M.

Adv Enzyme Regul. 2006;46:249-79. Epub 2006 Jul 18.


P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways.

Huynh N, Liu KH, Baldwin GS, He H.

Biochim Biophys Acta. 2010 Sep;1803(9):1106-13. doi: 10.1016/j.bbamcr.2010.05.007. Epub 2010 Jun 1.


p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model.

Chow HY, Jubb AM, Koch JN, Jaffer ZM, Stepanova D, Campbell DA, Duron SG, O'Farrell M, Cai KQ, Klein-Szanto AJ, Gutkind JS, Hoeflich KP, Chernoff J.

Cancer Res. 2012 Nov 15;72(22):5966-75. doi: 10.1158/0008-5472.CAN-12-2246. Epub 2012 Sep 14.


Erythropoietin-induced activation of the JAK2/STAT5, PI3K/Akt, and Ras/ERK pathways promotes malignant cell behavior in a modified breast cancer cell line.

Shi Z, Hodges VM, Dunlop EA, Percy MJ, Maxwell AP, El-Tanani M, Lappin TR.

Mol Cancer Res. 2010 Apr;8(4):615-26. doi: 10.1158/1541-7786.MCR-09-0264. Epub 2010 Mar 30.


PtdIns(3,4,5)P3-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling.

Liu HJ, Ooms LM, Srijakotre N, Man J, Vieusseux J, Waters JE, Feng Y, Bailey CG, Rasko JE, Price JT, Mitchell CA.

J Biol Chem. 2016 Aug 12;291(33):17258-70. doi: 10.1074/jbc.M116.743401. Epub 2016 Jun 29.


p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways.

Huynh N, Yim M, Chernoff J, Shulkes A, Baldwin GS, He H.

Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15;304(6):G561-7. doi: 10.1152/ajpgi.00218.2012. Epub 2013 Jan 10.


Regulation of tamoxifen sensitivity by a PAK1-EBP1 signalling pathway in breast cancer.

Ghosh A, Awasthi S, Peterson JR, Hamburger AW.

Br J Cancer. 2013 Feb 19;108(3):557-63. doi: 10.1038/bjc.2013.11. Epub 2013 Jan 29.


Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth.

Yen L, Cao Z, Wu X, Ingalla ER, Baron C, Young LJ, Gregg JP, Cardiff RD, Borowsky AD, Sweeney C, Carraway KL 3rd.

Cancer Res. 2006 Dec 1;66(23):11279-86.

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