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β2-adrenergic receptor-coupled phosphoinositide 3-kinase constrains cAMP-dependent increases in cardiac inotropy through phosphodiesterase 4 activation.

Gregg CJ, Steppan J, Gonzalez DR, Champion HC, Phan AC, Nyhan D, Shoukas AA, Hare JM, Barouch LA, Berkowitz DE.

Anesth Analg. 2010 Oct;111(4):870-7. doi: 10.1213/ANE.0b013e3181ee8312.


Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.

Leblais V, Jo SH, Chakir K, Maltsev V, Zheng M, Crow MT, Wang W, Lakatta EG, Xiao RP.

Circ Res. 2004 Dec 10;95(12):1183-90.


Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases.

Leroy J, Abi-Gerges A, Nikolaev VO, Richter W, Lechêne P, Mazet JL, Conti M, Fischmeister R, Vandecasteele G.

Circ Res. 2008 May 9;102(9):1091-100. doi: 10.1161/CIRCRESAHA.107.167817.


Interaction between phosphodiesterases in the regulation of the cardiac β-adrenergic pathway.

Zhao CY, Greenstein JL, Winslow RL.

J Mol Cell Cardiol. 2015 Nov;88:29-38. doi: 10.1016/j.yjmcc.2015.09.011.


Palmitoylation regulates intracellular trafficking of β2 adrenergic receptor/arrestin/phosphodiesterase 4D complexes in cardiomyocytes.

Liu R, Wang D, Shi Q, Fu Q, Hizon S, Xiang YK.

PLoS One. 2012;7(8):e42658. doi: 10.1371/journal.pone.0042658.


Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current.

Beca S, Helli PB, Simpson JA, Zhao D, Farman GP, Jones PP, Tian X, Wilson LS, Ahmad F, Chen SR, Movsesian MA, Manganiello V, Maurice DH, Conti M, Backx PH.

Circ Res. 2011 Oct 14;109(9):1024-30. doi: 10.1161/CIRCRESAHA.111.250464.


A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes.

Fu Q, Kim S, Soto D, De Arcangelis V, DiPilato L, Liu S, Xu B, Shi Q, Zhang J, Xiang YK.

J Biol Chem. 2014 May 23;289(21):14771-81. doi: 10.1074/jbc.M113.542589.


Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling.

Nikolaev VO, Bünemann M, Schmitteckert E, Lohse MJ, Engelhardt S.

Circ Res. 2006 Nov 10;99(10):1084-91.


Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals.

Abi-Gerges A, Richter W, Lefebvre F, Mateo P, Varin A, Heymes C, Samuel JL, Lugnier C, Conti M, Fischmeister R, Vandecasteele G.

Circ Res. 2009 Oct 9;105(8):784-92. doi: 10.1161/CIRCRESAHA.109.197947.


Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor.

Zhang SJ, Cheng H, Zhou YY, Wang DJ, Zhu W, Ziman B, Spurgoen H, Lefkowitz RJ, Lakatta EG, Koch WJ, Xiao RP.

J Biol Chem. 2000 Jul 14;275(28):21773-9.


Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes.

Isidori AM, Cornacchione M, Barbagallo F, Di Grazia A, Barrios F, Fassina L, Monaco L, Giannetta E, Gianfrilli D, Garofalo S, Zhang X, Chen X, Xiang YK, Lenzi A, Pellegrini M, Naro F.

Cardiovasc Res. 2015 Jun 1;106(3):408-20. doi: 10.1093/cvr/cvv123.


Contribution of the extracellular cAMP-adenosine pathway to dual coupling of β2-adrenoceptors to Gs and Gi proteins in mouse skeletal muscle.

Duarte T, Menezes-Rodrigues FS, Godinho RO.

J Pharmacol Exp Ther. 2012 Jun;341(3):820-8. doi: 10.1124/jpet.112.192997.


Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases.

Ghigo A, Perino A, Mehel H, Zahradníková A Jr, Morello F, Leroy J, Nikolaev VO, Damilano F, Cimino J, De Luca E, Richter W, Westenbroek R, Catterall WA, Zhang J, Yan C, Conti M, Gomez AM, Vandecasteele G, Hirsch E, Fischmeister R.

Circulation. 2012 Oct 23;126(17):2073-83. doi: 10.1161/CIRCULATIONAHA.112.114074.


PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes.

Kerfant BG, Zhao D, Lorenzen-Schmidt I, Wilson LS, Cai S, Chen SR, Maurice DH, Backx PH.

Circ Res. 2007 Aug 17;101(4):400-8.


Sex differences in SR Ca(2+) release in murine ventricular myocytes are regulated by the cAMP/PKA pathway.

Parks RJ, Ray G, Bienvenu LA, Rose RA, Howlett SE.

J Mol Cell Cardiol. 2014 Oct;75:162-73. doi: 10.1016/j.yjmcc.2014.07.006.


β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells.

Zhai K, Hubert F, Nicolas V, Ji G, Fischmeister R, Leblais V.

PLoS One. 2012;7(10):e47826. doi: 10.1371/journal.pone.0047826.

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