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Items: 1 to 20 of 142

1.

Effect of hepatitis C virus infection on the mRNA expression of drug transporters and cytochrome p450 enzymes in chimeric mice with humanized liver.

Kikuchi R, McCown M, Olson P, Tateno C, Morikawa Y, Katoh Y, Bourdet DL, Monshouwer M, Fretland AJ.

Drug Metab Dispos. 2010 Nov;38(11):1954-61. doi: 10.1124/dmd.109.031732. Epub 2010 Aug 6.

2.

Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients.

Nakai K, Tanaka H, Hanada K, Ogata H, Suzuki F, Kumada H, Miyajima A, Ishida S, Sunouchi M, Habano W, Kamikawa Y, Kubota K, Kita J, Ozawa S, Ohno Y.

Drug Metab Dispos. 2008 Sep;36(9):1786-93. doi: 10.1124/dmd.107.020073. Epub 2008 May 30.

3.

Expression of human cytochromes P450 in chimeric mice with humanized liver.

Katoh M, Matsui T, Nakajima M, Tateno C, Kataoka M, Soeno Y, Horie T, Iwasaki K, Yoshizato K, Yokoi T.

Drug Metab Dispos. 2004 Dec;32(12):1402-10. Epub 2004 Sep 21.

4.

Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver.

Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.

Drug Metab Dispos. 2012 Feb;40(2):322-8. doi: 10.1124/dmd.111.040923. Epub 2011 Nov 2.

5.

Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS.

Ohtsuki S, Kawakami H, Inoue T, Nakamura K, Tateno C, Katsukura Y, Obuchi W, Uchida Y, Kamiie J, Horie T, Terasaki T.

Drug Metab Dispos. 2014 Jun;42(6):1039-43. doi: 10.1124/dmd.114.057646. Epub 2014 Apr 7.

6.

Evaluation of mRNA expression of human drug-metabolizing enzymes and transporters in chimeric mouse with humanized liver.

Nishimura M, Yoshitsugu H, Yokoi T, Tateno C, Kataoka M, Horie T, Yoshizato K, Naito S.

Xenobiotica. 2005 Sep;35(9):877-90.

PMID:
16308282
7.

In vivo induction of human cytochrome P450 3A4 by rifabutin in chimeric mice with humanized liver.

Katoh M, Watanabe M, Tabata T, Sato Y, Nakajima M, Nishimura M, Naito S, Tateno C, Iwasaki K, Yoshizato K, Yokoi T.

Xenobiotica. 2005 Sep;35(9):863-75.

PMID:
16308281
8.

Investigation of drug-drug interactions caused by human pregnane X receptor-mediated induction of CYP3A4 and CYP2C subfamilies in chimeric mice with a humanized liver.

Hasegawa M, Tahara H, Inoue R, Kakuni M, Tateno C, Ushiki J.

Drug Metab Dispos. 2012 Mar;40(3):474-80. doi: 10.1124/dmd.111.042754. Epub 2011 Nov 29.

9.

Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver.

Kato K, Ohbuchi M, Hamamura S, Ohshita H, Kazuki Y, Oshimura M, Sato K, Nakada N, Kawamura A, Usui T, Kamimura H, Tateno C.

Drug Metab Dispos. 2015 Aug;43(8):1208-17. doi: 10.1124/dmd.115.063479. Epub 2015 May 15.

10.

Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities.

Ohtsuki S, Schaefer O, Kawakami H, Inoue T, Liehner S, Saito A, Ishiguro N, Kishimoto W, Ludwig-Schwellinger E, Ebner T, Terasaki T.

Drug Metab Dispos. 2012 Jan;40(1):83-92. doi: 10.1124/dmd.111.042259. Epub 2011 Oct 12.

11.

In vivo induction of human cytochrome P450 enzymes expressed in chimeric mice with humanized liver.

Katoh M, Matsui T, Nakajima M, Tateno C, Soeno Y, Horie T, Iwasaki K, Yoshizato K, Yokoi T.

Drug Metab Dispos. 2005 Jun;33(6):754-63. Epub 2005 Mar 15.

12.

Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor.

Kamiya N, Iwao E, Hiraga N, Tsuge M, Imamura M, Takahashi S, Miyoshi S, Tateno C, Yoshizato K, Chayama K.

J Gen Virol. 2010 Jul;91(Pt 7):1668-77. doi: 10.1099/vir.0.019315-0. Epub 2010 Feb 17.

PMID:
20164258
13.

Gene expression profiles of drug-metabolizing enzymes and transporters with an overexpression of hepatocyte growth factor.

Kakizaki S, Yamazaki Y, Kosone T, Horiguchi N, Sohara N, Sato K, Takagi H, Yoshinari K, Mori M.

Liver Int. 2007 Feb;27(1):109-19. Erratum in: Liver Int. 2007 Jun;27(5):733. Horigichi, Norio [corrected to Horiguchi, Norio].

PMID:
17241389
14.

The effect of Nrf2 knockout on the constitutive expression of drug metabolizing enzymes and transporters in C57Bl/6 mice livers.

Anwar-Mohamed A, Degenhardt OS, El Gendy MA, Seubert JM, Kleeberger SR, El-Kadi AO.

Toxicol In Vitro. 2011 Jun;25(4):785-95. doi: 10.1016/j.tiv.2011.01.014. Epub 2011 Jan 31.

PMID:
21281708
15.

Expression of human phase II enzymes in chimeric mice with humanized liver.

Katoh M, Matsui T, Okumura H, Nakajima M, Nishimura M, Naito S, Tateno C, Yoshizato K, Yokoi T.

Drug Metab Dispos. 2005 Sep;33(9):1333-40. Epub 2005 Jun 2.

16.

Ultra-rapid cardiotoxicity of the hepatitis C virus protease inhibitor BILN 2061 in the urokinase-type plasminogen activator mouse.

Vanwolleghem T, Meuleman P, Libbrecht L, Roskams T, De Vos R, Leroux-Roels G.

Gastroenterology. 2007 Oct;133(4):1144-55. Epub 2007 Jul 10.

PMID:
17919490
17.

Hepatitis C virus infection in mouse hepatoma cells co-expressing human CD81 and Sip-L.

Yeh CT, Lai HY, Yeh YJ, Cheng JC.

Biochem Biophys Res Commun. 2008 Jul 18;372(1):157-61. doi: 10.1016/j.bbrc.2008.05.018. Epub 2008 May 12.

PMID:
18474223
18.

Chimeric mice with humanized liver.

Katoh M, Tateno C, Yoshizato K, Yokoi T.

Toxicology. 2008 Apr 3;246(1):9-17. doi: 10.1016/j.tox.2007.11.012. Epub 2007 Nov 22. Review.

PMID:
18248870
19.

Transcriptional activation of cytochrome P450 2B1/2 genes in rat liver by diallyl sulfide, a compound derived from garlic.

Pan J, Hong JY, Ma BL, Ning SM, Paranawithana SR, Yang CS.

Arch Biochem Biophys. 1993 May;302(2):337-42.

PMID:
8489239
20.

Utility of a novel Oatp1b2 knockout mouse model for evaluating the role of Oatp1b2 in the hepatic uptake of model compounds.

Chen C, Stock JL, Liu X, Shi J, Van Deusen JW, DiMattia DA, Dullea RG, de Morais SM.

Drug Metab Dispos. 2008 Sep;36(9):1840-5. doi: 10.1124/dmd.108.020594. Epub 2008 Jun 12.

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