Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 85


Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis even in the absence of ovarian hormones.

Dong J, Tong T, Reynado AM, Rosen JM, Huang S, Li Y.

Dev Biol. 2010 Oct 15;346(2):196-203. doi: 10.1016/j.ydbio.2010.07.027. Epub 2010 Aug 4.


Genetic ablation of caveolin-1 in mammary epithelial cells increases milk production and hyper-activates STAT5a signaling.

Sotgia F, Schubert W, Pestell RG, Lisanti MP.

Cancer Biol Ther. 2006 Mar;5(3):292-7. Epub 2006 Mar 9.


Signal transducer and activator of transcription 5a mediates mammary ductal branching and proliferation in the nulliparous mouse.

Santos SJ, Haslam SZ, Conrad SE.

Endocrinology. 2010 Jun;151(6):2876-85. doi: 10.1210/en.2009-1282. Epub 2010 Apr 14.


Mammary epithelial reconstitution with gene-modified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor formation.

Vafaizadeh V, Klemmt P, Brendel C, Weber K, Doebele C, Britt K, Grez M, Fehse B, Desriviéres S, Groner B.

Stem Cells. 2010 May;28(5):928-38. doi: 10.1002/stem.407.


Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A.

Yamaji D, Na R, Feuermann Y, Pechhold S, Chen W, Robinson GW, Hennighausen L.

Genes Dev. 2009 Oct 15;23(20):2382-7. doi: 10.1101/gad.1840109.


Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration.

Yamaji D, Kang K, Robinson GW, Hennighausen L.

Nucleic Acids Res. 2013 Feb 1;41(3):1622-36. doi: 10.1093/nar/gks1310. Epub 2012 Dec 28.


Estrogen and progesterone are critical regulators of Stat5a expression in the mouse mammary gland.

Santos SJ, Haslam SZ, Conrad SE.

Endocrinology. 2008 Jan;149(1):329-38. Epub 2007 Sep 20.


The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development.

Clarkson RW, Boland MP, Kritikou EA, Lee JM, Freeman TC, Tiffen PG, Watson CJ.

Mol Endocrinol. 2006 Mar;20(3):675-85. Epub 2005 Nov 17.


Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation.

Liu X, Robinson GW, Hennighausen L.

Mol Endocrinol. 1996 Dec;10(12):1496-506.


Stat5a is mandatory for adult mammary gland development and lactogenesis.

Liu X, Robinson GW, Wagner KU, Garrett L, Wynshaw-Boris A, Hennighausen L.

Genes Dev. 1997 Jan 15;11(2):179-86.


Elf5 conditional knockout mice reveal its role as a master regulator in mammary alveolar development: failure of Stat5 activation and functional differentiation in the absence of Elf5.

Choi YS, Chakrabarti R, Escamilla-Hernandez R, Sinha S.

Dev Biol. 2009 May 15;329(2):227-41. doi: 10.1016/j.ydbio.2009.02.032. Epub 2009 Mar 6.


Induction of mammary gland differentiation in transgenic mice by the fatty acid-binding protein MRG.

Wang M, Liu YE, Goldberg ID, Shi YE.

J Biol Chem. 2003 Nov 21;278(47):47319-25. Epub 2003 Sep 15.


Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation.

Ke Y, Lesperance J, Zhang EE, Bard-Chapeau EA, Oshima RG, Muller WJ, Feng GS.

J Biol Chem. 2006 Nov 10;281(45):34374-80. Epub 2006 Sep 7.


Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland.

Nagy T, Wei H, Shen TL, Peng X, Liang CC, Gan B, Guan JL.

J Biol Chem. 2007 Oct 26;282(43):31766-76. Epub 2007 Aug 23.


Stat5a increases lactation of dairy cow mammary gland epithelial cells cultured in vitro.

Liu XF, Li M, Li QZ, Lu LM, Tong HL, Gao XJ.

In Vitro Cell Dev Biol Anim. 2012 Oct;48(9):554-61. doi: 10.1007/s11626-012-9545-5. Epub 2012 Oct 9.


Alveolar progenitor cells develop in mouse mammary glands independent of pregnancy and lactation.

Booth BW, Boulanger CA, Smith GH.

J Cell Physiol. 2007 Sep;212(3):729-36.


Peroxisome proliferator-activated receptor gamma regulates expression of signal transducer and activator of transcription 5A.

Olsen H, Haldosén LA.

Exp Cell Res. 2006 May 1;312(8):1371-80. Epub 2006 Feb 2.


Supplemental Content

Support Center