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Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains.

Reynoird N, Schwartz BE, Delvecchio M, Sadoul K, Meyers D, Mukherjee C, Caron C, Kimura H, Rousseaux S, Cole PA, Panne D, French CA, Khochbin S.

EMBO J. 2010 Sep 1;29(17):2943-52. doi: 10.1038/emboj.2010.176. Epub 2010 Jul 30.


Mechanistic analysis of the role of bromodomain-containing protein 4 (BRD4) in BRD4-NUT oncoprotein-induced transcriptional activation.

Wang R, You J.

J Biol Chem. 2015 Jan 30;290(5):2744-58. doi: 10.1074/jbc.M114.600759. Epub 2014 Dec 15.


Perturbation of BRD4 protein function by BRD4-NUT protein abrogates cellular differentiation in NUT midline carcinoma.

Yan J, Diaz J, Jiao J, Wang R, You J.

J Biol Chem. 2011 Aug 5;286(31):27663-75. doi: 10.1074/jbc.M111.246975. Epub 2011 Jun 7.


The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains.

Alekseyenko AA, Walsh EM, Wang X, Grayson AR, Hsi PT, Kharchenko PV, Kuroda MI, French CA.

Genes Dev. 2015 Jul 15;29(14):1507-23. doi: 10.1101/gad.267583.115.


BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.

French CA, Ramirez CL, Kolmakova J, Hickman TT, Cameron MJ, Thyne ME, Kutok JL, Toretsky JA, Tadavarthy AK, Kees UR, Fletcher JA, Aster JC.

Oncogene. 2008 Apr 3;27(15):2237-42. Epub 2007 Oct 15.


BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma.

French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA.

Cancer Res. 2003 Jan 15;63(2):304-7.


Activation of SOX2 expression by BRD4-NUT oncogenic fusion drives neoplastic transformation in NUT midline carcinoma.

Wang R, Liu W, Helfer CM, Bradner JE, Hornick JL, Janicki SM, French CA, You J.

Cancer Res. 2014 Jun 15;74(12):3332-43. doi: 10.1158/0008-5472.CAN-13-2658. Epub 2014 Apr 15.


BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia.

Roe JS, Mercan F, Rivera K, Pappin DJ, Vakoc CR.

Mol Cell. 2015 Jun 18;58(6):1028-39. doi: 10.1016/j.molcel.2015.04.011. Epub 2015 May 14.


Regulation of Lef-mediated transcription and p53-dependent pathway by associating beta-catenin with CBP/p300.

Miyagishi M, Fujii R, Hatta M, Yoshida E, Araya N, Nagafuchi A, Ishihara S, Nakajima T, Fukamizu A.

J Biol Chem. 2000 Nov 10;275(45):35170-5.


The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis.

Dey A, Chitsaz F, Abbasi A, Misteli T, Ozato K.

Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8758-63. Epub 2003 Jul 2.


The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation.

Wu SY, Chiang CM.

J Biol Chem. 2007 May 4;282(18):13141-5. Epub 2007 Feb 28. Review.


Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB.

Asahara H, Santoso B, Guzman E, Du K, Cole PA, Davidson I, Montminy M.

Mol Cell Biol. 2001 Dec;21(23):7892-900.


Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting.

Wu SY, Lee AY, Lai HT, Zhang H, Chiang CM.

Mol Cell. 2013 Mar 7;49(5):843-57. doi: 10.1016/j.molcel.2012.12.006. Epub 2013 Jan 11.


Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription.

Dey A, Nishiyama A, Karpova T, McNally J, Ozato K.

Mol Biol Cell. 2009 Dec;20(23):4899-909. doi: 10.1091/mbc.E09-05-0380. Epub 2009 Oct 7.


Binding and modulation of p53 by p300/CBP coactivators.

Lill NL, Grossman SR, Ginsberg D, DeCaprio J, Livingston DM.

Nature. 1997 Jun 19;387(6635):823-7.


Cooperative binding of two acetylation marks on a histone tail by a single bromodomain.

Morinière J, Rousseaux S, Steuerwald U, Soler-López M, Curtet S, Vitte AL, Govin J, Gaucher J, Sadoul K, Hart DJ, Krijgsveld J, Khochbin S, Müller CW, Petosa C.

Nature. 2009 Oct 1;461(7264):664-8. doi: 10.1038/nature08397.


Novel BRD4-NUT fusion isoforms increase the pathogenic complexity in NUT midline carcinoma.

Thompson-Wicking K, Francis RW, Stirnweiss A, Ferrari E, Welch MD, Baker E, Murch AR, Gout AM, Carter KW, Charles AK, Phillips MB, Kees UR, Beesley AH.

Oncogene. 2013 Sep 26;32(39):4664-74. doi: 10.1038/onc.2012.487. Epub 2012 Nov 5.


Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis.

Albanese C, D'Amico M, Reutens AT, Fu M, Watanabe G, Lee RJ, Kitsis RN, Henglein B, Avantaggiati M, Somasundaram K, Thimmapaya B, Pestell RG.

J Biol Chem. 1999 Nov 26;274(48):34186-95.


Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription.

Tini M, Benecke A, Um SJ, Torchia J, Evans RM, Chambon P.

Mol Cell. 2002 Feb;9(2):265-77.

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