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Regulation of Skp2 levels by the Pim-1 protein kinase.

Cen B, Mahajan S, Zemskova M, Beharry Z, Lin YW, Cramer SD, Lilly MB, Kraft AS.

J Biol Chem. 2010 Sep 17;285(38):29128-37. doi: 10.1074/jbc.M110.137240. Epub 2010 Jul 27.


Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.

Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M.

Nature. 2004 Mar 11;428(6979):190-3.


Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas.

Lwin T, Hazlehurst LA, Dessureault S, Lai R, Bai W, Sotomayor E, Moscinski LC, Dalton WS, Tao J.

Blood. 2007 Sep 1;110(5):1631-8. Epub 2007 May 14.


Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase.

Rodier G, Coulombe P, Tanguay PL, Boutonnet C, Meloche S.

EMBO J. 2008 Feb 20;27(4):679-91. doi: 10.1038/emboj.2008.6. Epub 2008 Jan 31.


Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer.

Huang KT, Pavlides SC, Lecanda J, Blank SV, Mittal KR, Gold LI.

PLoS One. 2012;7(9):e46072. doi: 10.1371/journal.pone.0046072. Epub 2012 Sep 27.


Early mitotic inhibitor-1, an anaphase-promoting complex/cyclosome inhibitor, can control tumor cell proliferation in hepatocellular carcinoma: correlation with Skp2 stability and degradation of p27(Kip1).

Zhao Y, Tang Q, Ni R, Huang X, Wang Y, Lu C, Shen A, Wang Y, Li C, Yuan Q, Chen H, Cheng C, He S.

Hum Pathol. 2013 Mar;44(3):365-73. doi: 10.1016/j.humpath.2012.03.030. Epub 2012 Sep 17.


Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by SKP2.

Ungermannova D, Gao Y, Liu X.

J Biol Chem. 2005 Aug 26;280(34):30301-9. Epub 2005 Jun 24.


p27(Kip1) signaling: Transcriptional and post-translational regulation.

Hnit SS, Xie C, Yao M, Holst J, Bensoussan A, De Souza P, Li Z, Dong Q.

Int J Biochem Cell Biol. 2015 Nov;68:9-14. doi: 10.1016/j.biocel.2015.08.005. Epub 2015 Aug 14. Review.


SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis.

Calvisi DF, Ladu S, Pinna F, Frau M, Tomasi ML, Sini M, Simile MM, Bonelli P, Muroni MR, Seddaiu MA, Lim DS, Feo F, Pascale RM.

Gastroenterology. 2009 Nov;137(5):1816-26.e1-10. doi: 10.1053/j.gastro.2009.08.005. Epub 2009 Aug 15.


Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.

Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG Jr.

Nature. 2004 Mar 11;428(6979):194-8.


C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression.

Pawar SA, Sarkar TR, Balamurugan K, Sharan S, Wang J, Zhang Y, Dowdy SF, Huang AM, Sterneck E.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9210-5. doi: 10.1073/pnas.0913813107. Epub 2010 May 3.


Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2.

Rosner M, Hengstschläger M.

J Biol Chem. 2004 Nov 19;279(47):48707-15. Epub 2004 Sep 8.


Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization.

Bashir T, Pagan JK, Busino L, Pagano M.

Cell Cycle. 2010 Mar 1;9(5):971-4. Epub 2010 Mar 9.


Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit.

Binné UK, Classon MK, Dick FA, Wei W, Rape M, Kaelin WG Jr, Näär AM, Dyson NJ.

Nat Cell Biol. 2007 Feb;9(2):225-32. Epub 2006 Dec 24. Erratum in: Nat Cell Biol. 2007 Mar;9(3):353.


Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway.

Hara T, Kamura T, Nakayama K, Oshikawa K, Hatakeyama S, Nakayama K.

J Biol Chem. 2001 Dec 28;276(52):48937-43. Epub 2001 Oct 26.


Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.

Gao D, Inuzuka H, Tseng A, Chin RY, Toker A, Wei W.

Nat Cell Biol. 2009 Apr;11(4):397-408. doi: 10.1038/ncb1847. Epub 2009 Mar 8.


Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis.

Fujita T, Liu W, Doihara H, Wan Y.

Am J Pathol. 2008 Jul;173(1):217-28. doi: 10.2353/ajpath.2008.070957. Epub 2008 Jun 5.


Nuclear translocation of Skp2 facilitates its destruction in response to TGFβ signaling.

Hu D, Liu W, Wu G, Wan Y.

Cell Cycle. 2011 Jan 15;10(2):285-92. Epub 2011 Jan 15.


Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation.

Liu E, Li X, Yan F, Zhao Q, Wu X.

J Biol Chem. 2004 Apr 23;279(17):17283-8. Epub 2004 Mar 5.

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