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Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism.

Chiang PM, Ling J, Jeong YH, Price DL, Aja SM, Wong PC.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16320-4. doi: 10.1073/pnas.1002176107. Epub 2010 Jul 26.


TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis.

Stallings NR, Puttaparthi K, Dowling KJ, Luther CM, Burns DK, Davis K, Elliott JL.

PLoS One. 2013 Aug 13;8(8):e71793. doi: 10.1371/journal.pone.0071793. eCollection 2013.


TDP-43 is a developmentally regulated protein essential for early embryonic development.

Sephton CF, Good SK, Atkin S, Dewey CM, Mayer P 3rd, Herz J, Yu G.

J Biol Chem. 2010 Feb 26;285(9):6826-34. doi: 10.1074/jbc.M109.061846. Epub 2009 Dec 29. Erratum in: J Biol Chem. 2010 Dec 3;285(49):38740.


Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments.

Swarup V, Phaneuf D, Bareil C, Robertson J, Rouleau GA, Kriz J, Julien JP.

Brain. 2011 Sep;134(Pt 9):2610-26. doi: 10.1093/brain/awr159. Epub 2011 Jul 13.


Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.

Igaz LM, Kwong LK, Lee EB, Chen-Plotkin A, Swanson E, Unger T, Malunda J, Xu Y, Winton MJ, Trojanowski JQ, Lee VM.

J Clin Invest. 2011 Feb;121(2):726-38. doi: 10.1172/JCI44867. Epub 2011 Jan 4.


A novel TARDBP insertion/deletion mutation in the flail arm variant of amyotrophic lateral sclerosis.

Solski JA, Yang S, Nicholson GA, Luquin N, Williams KL, Fernando R, Pamphlett R, Blair IP.

Amyotroph Lateral Scler. 2012 Sep;13(5):465-70. doi: 10.3109/17482968.2012.662690. Epub 2012 Mar 16.


Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo.

Kabashi E, Lin L, Tradewell ML, Dion PA, Bercier V, Bourgouin P, Rochefort D, Bel Hadj S, Durham HD, Vande Velde C, Rouleau GA, Drapeau P.

Hum Mol Genet. 2010 Feb 15;19(4):671-83. doi: 10.1093/hmg/ddp534. Epub 2009 Dec 3. Erratum in: Hum Mol Genet. 2010 Aug 1;19(15):3102.


Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs.

Suzuki H, Shibagaki Y, Hattori S, Matsuoka M.

Hum Mol Genet. 2015 Mar 15;24(6):1513-27. doi: 10.1093/hmg/ddu563. Epub 2014 Nov 6.


Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS.

Ke YD, van Hummel A, Stevens CH, Gladbach A, Ippati S, Bi M, Lee WS, Krüger S, van der Hoven J, Volkerling A, Bongers A, Halliday G, Haass NK, Kiernan M, Delerue F, Ittner LM.

Acta Neuropathol. 2015 Nov;130(5):661-78. doi: 10.1007/s00401-015-1486-0. Epub 2015 Oct 5.


Hyperproduction of IL-6 caused by aberrant TDP-43 overexpression in high-fat diet-induced obese mice.

Lee S, Lee TA, Song SJ, Park T, Park B.

FEBS Lett. 2015 Jul 8;589(15):1825-31. doi: 10.1016/j.febslet.2015.05.040. Epub 2015 May 30.


TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis.

Wu LS, Cheng WC, Hou SC, Yan YT, Jiang ST, Shen CK.

Genesis. 2010 Jan;48(1):56-62. doi: 10.1002/dvg.20584.


Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.

Lauranzano E, Pozzi S, Pasetto L, Stucchi R, Massignan T, Paolella K, Mombrini M, Nardo G, Lunetta C, Corbo M, Mora G, Bendotti C, Bonetto V.

Brain. 2015 Apr;138(Pt 4):974-91. doi: 10.1093/brain/awv005. Epub 2015 Feb 12.


Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle.

Dokas J, Chadt A, Nolden T, Himmelbauer H, Zierath JR, Joost HG, Al-Hasani H.

Endocrinology. 2013 Oct;154(10):3502-14. doi: 10.1210/en.2012-2147. Epub 2013 Jul 26.


Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity.

Chadt A, Leicht K, Deshmukh A, Jiang LQ, Scherneck S, Bernhardt U, Dreja T, Vogel H, Schmolz K, Kluge R, Zierath JR, Hultschig C, Hoeben RC, Schürmann A, Joost HG, Al-Hasani H.

Nat Genet. 2008 Nov;40(11):1354-9. doi: 10.1038/ng.244. Epub 2008 Oct 19.


TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents.

Valerio A, Cardile A, Cozzi V, Bracale R, Tedesco L, Pisconti A, Palomba L, Cantoni O, Clementi E, Moncada S, Carruba MO, Nisoli E.

J Clin Invest. 2006 Oct;116(10):2791-8. Epub 2006 Sep 14.


Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin.

Amlie-Wolf A, Ryvkin P, Tong R, Dragomir I, Suh E, Xu Y, Van Deerlin VM, Gregory BD, Kwong LK, Trojanowski JQ, Lee VM, Wang LS, Lee EB.

PLoS One. 2015 Oct 28;10(10):e0141836. doi: 10.1371/journal.pone.0141836. eCollection 2015.


Significant associations of the mitochondrial transcription factor A promoter polymorphisms with marbling and subcutaneous fat depth in Wagyu x Limousin F2 crosses.

Jiang Z, Kunej T, Michal JJ, Gaskins CT, Reeves JJ, Busboom JR, Dovc P, Wright RW Jr.

Biochem Biophys Res Commun. 2005 Aug 26;334(2):516-23.


Gene targeting of mouse Tardbp negatively affects Masp2 expression.

Dib S, Xiao S, Miletic D, Robertson J.

PLoS One. 2014 Apr 16;9(4):e95373. doi: 10.1371/journal.pone.0095373. eCollection 2014.

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