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Items: 1 to 20 of 90

1.

Novel mechanism of reducing tumourigenesis: upregulation of the DNA repair enzyme OGG1 by rapamycin-mediated AMPK activation and mTOR inhibition.

Habib SL, Kasinath BS, Arya RR, Vexler S, Velagapudi C.

Eur J Cancer. 2010 Oct;46(15):2806-20. doi: 10.1016/j.ejca.2010.06.117.

PMID:
20656472
2.

Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients.

Habib SL.

Mol Cancer. 2009 Mar 5;8:13. doi: 10.1186/1476-4598-8-13.

3.

Tuberin regulates the DNA repair enzyme OGG1.

Habib SL, Riley DJ, Mahimainathan L, Bhandari B, Choudhury GG, Abboud HE.

Am J Physiol Renal Physiol. 2008 Jan;294(1):F281-90.

4.

Renal tumours in a Tsc2(+/-) mouse model do not show feedback inhibition of Akt and are effectively prevented by rapamycin.

Yang J, Kalogerou M, Samsel PA, Zhang Y, Griffiths DF, Gallacher J, Sampson JR, Shen MH.

Oncogene. 2015 Feb 12;34(7):922-31. doi: 10.1038/onc.2014.17.

PMID:
24632604
5.

Novel mechanism of regulation of the DNA repair enzyme OGG1 in tuberin-deficient cells.

Habib SL, Bhandari BK, Sadek N, Abboud-Werner SL, Abboud HE.

Carcinogenesis. 2010 Nov;31(11):2022-30. doi: 10.1093/carcin/bgq189.

6.

Mechanism of activation of AMPK and upregulation of OGG1 by rapamycin in cancer cells.

Habib SL.

Oncotarget. 2011 Dec;2(12):958-9. No abstract available.

7.

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity.

Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N.

J Biol Chem. 2005 Sep 16;280(37):32081-9.

8.

Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival.

Campos T, Ziehe J, Fuentes-Villalobos F, Riquelme O, Peña D, Troncoso R, Lavandero S, Morin V, Pincheira R, Castro AF.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1200-7. doi: 10.1016/j.bbamcr.2016.03.009.

PMID:
26975583
10.

Inhibition of the mTOR/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake.

Ginion A, Auquier J, Benton CR, Mouton C, Vanoverschelde JL, Hue L, Horman S, Beauloye C, Bertrand L.

Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H469-77. doi: 10.1152/ajpheart.00986.2010.

11.
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13.

Novel mechanism of regulation of fibrosis in kidney tumor with tuberous sclerosis.

Liang S, Cuevas G, Tizani S, Salas T, Liu H, Li B, Habib SL.

Mol Cancer. 2013 May 25;12:49. doi: 10.1186/1476-4598-12-49.

14.

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth.

Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan KL.

Cell. 2006 Sep 8;126(5):955-68.

15.

Tuberous sclerosis complex and DNA repair.

Habib SL.

Adv Exp Med Biol. 2010;685:84-94. Review.

PMID:
20687497
17.

Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors.

Kenerson HL, Aicher LD, True LD, Yeung RS.

Cancer Res. 2002 Oct 15;62(20):5645-50.

18.

Effects of rapamycin in the Eker rat model of tuberous sclerosis complex.

Kenerson H, Dundon TA, Yeung RS.

Pediatr Res. 2005 Jan;57(1):67-75.

PMID:
15557109
19.

GLUT1 enhances mTOR activity independently of TSC2 and AMPK.

Buller CL, Heilig CW, Brosius FC 3rd.

Am J Physiol Renal Physiol. 2011 Sep;301(3):F588-96. doi: 10.1152/ajprenal.00472.2010.

20.
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