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Items: 1 to 20 of 143

1.

Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases.

Tremblay JM, Kuo CL, Abeijon C, Sepulveda J, Oyler G, Hu X, Jin MM, Shoemaker CB.

Toxicon. 2010 Nov;56(6):990-8. doi: 10.1016/j.toxicon.2010.07.003. Epub 2010 Jul 14.

2.

A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic alpha-exosite binding region.

Dong J, Thompson AA, Fan Y, Lou J, Conrad F, Ho M, Pires-Alves M, Wilson BA, Stevens RC, Marks JD.

J Mol Biol. 2010 Apr 9;397(4):1106-18. doi: 10.1016/j.jmb.2010.01.070. Epub 2010 Feb 6.

3.

Peptide inhibitors of botulinum neurotoxin serotype A: design, inhibition, cocrystal structures, structure-activity relationship and pharmacophore modeling.

Kumar G, Kumaran D, Ahmed SA, Swaminathan S.

Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):511-20. doi: 10.1107/S0907444912003551. Epub 2012 Apr 17.

PMID:
22525749
4.

Progress in cell based assays for botulinum neurotoxin detection.

Pellett S.

Curr Top Microbiol Immunol. 2013;364:257-85. doi: 10.1007/978-3-642-33570-9_12. Review.

5.

Algal chloroplast produced camelid VH H antitoxins are capable of neutralizing botulinum neurotoxin.

Barrera DJ, Rosenberg JN, Chiu JG, Chang YN, Debatis M, Ngoi SM, Chang JT, Shoemaker CB, Oyler GA, Mayfield SP.

Plant Biotechnol J. 2015 Jan;13(1):117-24. doi: 10.1111/pbi.12244. Epub 2014 Sep 17.

6.

Botulinum neurotoxins and botulism: a novel therapeutic approach.

Thanongsaksrikul J, Chaicumpa W.

Toxins (Basel). 2011 May;3(5):469-88. doi: 10.3390/toxins3050469. Epub 2011 May 13. Review.

7.

Accelerated neuronal cell recovery from Botulinum neurotoxin intoxication by targeted ubiquitination.

Kuo CL, Oyler GA, Shoemaker CB.

PLoS One. 2011;6(5):e20352. doi: 10.1371/journal.pone.0020352. Epub 2011 May 24.

8.

Characterization of the antibody response to the receptor binding domain of botulinum neurotoxin serotypes A and E.

Baldwin MR, Tepp WH, Pier CL, Bradshaw M, Ho M, Wilson BA, Fritz RB, Johnson EA, Barbieri JT.

Infect Immun. 2005 Oct;73(10):6998-7005.

9.

Molecular immune recognition of botulinum neurotoxin B. The light chain regions that bind human blocking antibodies from toxin-treated cervical dystonia patients. Antigenic structure of the entire BoNT/B molecule.

Atassi MZ, Jankovic J, Steward LE, Aoki KR, Dolimbek BZ.

Immunobiology. 2012 Jan;217(1):17-27. doi: 10.1016/j.imbio.2011.08.009. Epub 2011 Aug 30.

PMID:
21962573
10.

Llama-derived single-domain antibodies for the detection of botulinum A neurotoxin.

Swain MD, Anderson GP, Zabetakis D, Bernstein RD, Liu JL, Sherwood LJ, Hayhurst A, Goldman ER.

Anal Bioanal Chem. 2010 Sep;398(1):339-48. doi: 10.1007/s00216-010-3905-3. Epub 2010 Jun 28.

11.

Facile electrochemical detection of botulinum neurotoxin type E using a two-step proteolytic cleavage.

Park S, Shin YM, Song JJ, Yang H.

Biosens Bioelectron. 2015 Oct 15;72:211-7. doi: 10.1016/j.bios.2015.05.016. Epub 2015 May 7.

PMID:
25982730
12.

Production of a neutralizing mouse-human chimeric antibody against botulinum neurotoxin serotype E.

Mukamoto M, Maeda H, Kohda T, Nozaki C, Takahashi M, Kozaki S.

Jpn J Infect Dis. 2013;66(1):46-50.

13.

Endopeptidase activities of botulinum neurotoxin type B complex, holotoxin, and light chain.

Wang HH, Riding S, Lindo P, Singh BR.

Appl Environ Microbiol. 2010 Oct;76(19):6658-63. doi: 10.1128/AEM.00731-10. Epub 2010 Aug 6.

14.

Camelid-derived heavy-chain nanobody against Clostridium botulinum neurotoxin E in Pichia pastoris.

Baghban R, Gargari SL, Rajabibazl M, Nazarian S, Bakherad H.

Biotechnol Appl Biochem. 2016 Mar-Apr;63(2):200-5. doi: 10.1002/bab.1226.

PMID:
24673401
15.

Mapping of the antibody-binding regions on botulinum neurotoxin H-chain domain 855-1296 with antitoxin antibodies from three host species.

Atassi MZ, Dolimbek BZ, Hayakari M, Middlebrook JL, Whitney B, Oshima M.

J Protein Chem. 1996 Oct;15(7):691-700.

PMID:
8968960
16.

Unique substrate recognition by botulinum neurotoxins serotypes A and E.

Chen S, Barbieri JT.

J Biol Chem. 2006 Apr 21;281(16):10906-11. Epub 2006 Feb 14.

17.

Binding of Clostridium botulinum type C and D neurotoxins to ganglioside and phospholipid. Novel insights into the receptor for clostridial neurotoxins.

Tsukamoto K, Kohda T, Mukamoto M, Takeuchi K, Ihara H, Saito M, Kozaki S.

J Biol Chem. 2005 Oct 21;280(42):35164-71. Epub 2005 Aug 22.

19.

Improved detection methods by genetic and immunological techniques for botulinum C/D and D/C mosaic neurotoxins.

Nakamura K, Kohda T, Seto Y, Mukamoto M, Kozaki S.

Vet Microbiol. 2013 Mar 23;162(2-4):881-90. doi: 10.1016/j.vetmic.2012.11.009. Epub 2012 Nov 10.

PMID:
23206412
20.

Preliminary X-ray crystallographic study of the receptor-binding domain of the D/C mosaic neurotoxin from Clostridium botulinum.

Nuemket N, Tanaka Y, Tsukamoto K, Tsuji T, Nakamura K, Kozaki S, Yao M, Tanaka I.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 May 1;66(Pt 5):608-10. doi: 10.1107/S1744309110012182. Epub 2010 Apr 30.

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