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Items: 1 to 20 of 121

1.

Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor.

Zheng Y, Peng M, Wang Z, Asara JM, Tyner AL.

Mol Cell Biol. 2010 Sep;30(17):4280-92. doi: 10.1128/MCB.00024-10. Epub 2010 Jul 6.

2.

Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.

Zheng Y, Gierut J, Wang Z, Miao J, Asara JM, Tyner AL.

Oncogene. 2013 Sep 5;32(36):4304-12. doi: 10.1038/onc.2012.427. Epub 2012 Oct 1.

3.

Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.

Lofgren KA, Ostrander JH, Housa D, Hubbard GK, Locatelli A, Bliss RL, Schwertfeger KL, Lange CA.

Breast Cancer Res. 2011 Sep 17;13(5):R89. doi: 10.1186/bcr2946.

4.

Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate.

Zheng Y, Asara JM, Tyner AL.

J Biol Chem. 2012 Jan 2;287(1):148-58. doi: 10.1074/jbc.M111.298117. Epub 2011 Nov 14.

5.

Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane.

Gierut J, Zheng Y, Bie W, Carroll RE, Ball-Kell S, Haegebarth A, Tyner AL.

Gastroenterology. 2011 Oct;141(4):1371-80, 1380.e1-2. doi: 10.1053/j.gastro.2011.06.071. Epub 2011 Jul 8.

6.

PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer.

Zheng Y, Wang Z, Bie W, Brauer PM, Perez White BE, Li J, Nogueira V, Raychaudhuri P, Hay N, Tonetti DA, Macias V, Kajdacsy-Balla A, Tyner AL.

Cancer Res. 2013 Sep 1;73(17):5426-37. doi: 10.1158/0008-5472.CAN-13-0443. Epub 2013 Jul 15. Erratum in: Cancer Res. 2013 Oct 1;73(19):6096.

7.

RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK.

Brauer PM, Tyner AL.

Cell Cycle. 2009 Sep 1;8(17):2728-32. Epub 2009 Sep 29. Review.

8.

Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine.

Haegebarth A, Bie W, Yang R, Crawford SE, Vasioukhin V, Fuchs E, Tyner AL.

Mol Cell Biol. 2006 Jul;26(13):4949-57.

9.

Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation.

Jiang LQ, Feng X, Zhou W, Knyazev PG, Ullrich A, Chen Z.

Oncogene. 2006 Sep 7;25(40):5495-506. Epub 2006 Apr 24.

PMID:
16636672
10.
11.

PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1.

Kang SA, Lee ES, Yoon HY, Randazzo PA, Lee ST.

J Biol Chem. 2010 Aug 20;285(34):26013-21. doi: 10.1074/jbc.M109.088971. Epub 2010 Jun 16.

12.

The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-catenin.

Brauer PM, Zheng Y, Evans MD, Dominguez-Brauer C, Peehl DM, Tyner AL.

PLoS One. 2011 Mar 30;6(3):e14789. doi: 10.1371/journal.pone.0014789.

13.
14.

PTK6 Localized at the Plasma Membrane Promotes Cell Proliferation and MigratiOn Through Phosphorylation of Eps8.

Shin WS, Shim HJ, Lee YH, Pyo M, Park JS, Ahn SY, Lee ST.

J Cell Biochem. 2017 Sep;118(9):2887-2895. doi: 10.1002/jcb.25939. Epub 2017 May 15.

PMID:
28214294
15.

Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6.

Palka-Hamblin HL, Gierut JJ, Bie W, Brauer PM, Zheng Y, Asara JM, Tyner AL.

J Cell Sci. 2010 Jan 15;123(Pt 2):236-45. doi: 10.1242/jcs.053264. Epub 2009 Dec 21.

16.

Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells.

Brauer PM, Zheng Y, Wang L, Tyner AL.

Cell Cycle. 2010 Oct 15;9(20):4190-9. Epub 2010 Oct 30.

18.

PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation.

Kang SA, Lee ST.

Biochem Biophys Res Commun. 2013 Feb 22;431(4):734-9. doi: 10.1016/j.bbrc.2013.01.046. Epub 2013 Jan 23.

PMID:
23352614
19.

Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK.

Brauer PM, Tyner AL.

Biochim Biophys Acta. 2010 Aug;1806(1):66-73. doi: 10.1016/j.bbcan.2010.02.003. Epub 2010 Feb 26. Review.

20.

Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer.

Zheng Y, Tyner AL.

Eur J Clin Invest. 2013 Apr;43(4):397-404. doi: 10.1111/eci.12050. Epub 2013 Feb 10. Review.

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