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Items: 1 to 20 of 116

1.

Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension.

Aldred MA, Comhair SA, Varella-Garcia M, Asosingh K, Xu W, Noon GP, Thistlethwaite PA, Tuder RM, Erzurum SC, Geraci MW, Coldren CD.

Am J Respir Crit Care Med. 2010 Nov 1;182(9):1153-60. doi: 10.1164/rccm.201003-0491OC. Epub 2010 Jun 25.

2.

Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension.

Hong KH, Lee YJ, Lee E, Park SO, Han C, Beppu H, Li E, Raizada MK, Bloch KD, Oh SP.

Circulation. 2008 Aug 12;118(7):722-30. doi: 10.1161/CIRCULATIONAHA.107.736801. Epub 2008 Jul 28.

3.

Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertension.

Zakrzewicz A, Hecker M, Marsh LM, Kwapiszewska G, Nejman B, Long L, Seeger W, Schermuly RT, Morrell NW, Morty RE, Eickelberg O.

Circulation. 2007 Jun 12;115(23):2957-68. Epub 2007 May 21.

4.

Endothelial-to-mesenchymal transition in pulmonary hypertension.

Ranchoux B, Antigny F, Rucker-Martin C, Hautefort A, Péchoux C, Bogaard HJ, Dorfmüller P, Remy S, Lecerf F, Planté S, Chat S, Fadel E, Houssaini A, Anegon I, Adnot S, Simonneau G, Humbert M, Cohen-Kaminsky S, Perros F.

Circulation. 2015 Mar 17;131(11):1006-18. doi: 10.1161/CIRCULATIONAHA.114.008750. Epub 2015 Jan 15.

5.

Altered MicroRNA processing in heritable pulmonary arterial hypertension: an important role for Smad-8.

Drake KM, Zygmunt D, Mavrakis L, Harbor P, Wang L, Comhair SA, Erzurum SC, Aldred MA.

Am J Respir Crit Care Med. 2011 Dec 15;184(12):1400-8. doi: 10.1164/rccm.201106-1130OC. Epub 2011 Sep 15.

6.

Endothelin-Bone morphogenetic protein type 2 receptor interaction induces pulmonary artery smooth muscle cell hyperplasia in pulmonary arterial hypertension.

Maruyama H, Dewachter C, Belhaj A, Rondelet B, Sakai S, Remmelink M, Vachiery JL, Naeije R, Dewachter L.

J Heart Lung Transplant. 2015 Mar;34(3):468-78. doi: 10.1016/j.healun.2014.09.011. Epub 2014 Sep 28.

PMID:
25447587
7.

In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug.

Hopper RK, Moonen JR, Diebold I, Cao A, Rhodes CJ, Tojais NF, Hennigs JK, Gu M, Wang L, Rabinovitch M.

Circulation. 2016 May 3;133(18):1783-94. doi: 10.1161/CIRCULATIONAHA.115.020617. Epub 2016 Apr 4.

8.

Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.

Meloche J, Courchesne A, Barrier M, Carter S, Bisserier M, Paulin R, Lauzon-Joset JF, Breuils-Bonnet S, Tremblay É, Biardel S, Racine C, Courture C, Bonnet P, Majka SM, Deshaies Y, Picard F, Provencher S, Bonnet S.

J Am Heart Assoc. 2013 Jan 16;2(1):e005157. doi: 10.1161/JAHA.112.005157.

9.

Genetics and genomics of pulmonary arterial hypertension.

Soubrier F, Chung WK, Machado R, Grünig E, Aldred M, Geraci M, Loyd JE, Elliott CG, Trembath RC, Newman JH, Humbert M.

J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D13-21. doi: 10.1016/j.jacc.2013.10.035. Review.

10.

Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.

Yang J, Li X, Al-Lamki RS, Southwood M, Zhao J, Lever AM, Grimminger F, Schermuly RT, Morrell NW.

Circ Res. 2010 Jul 23;107(2):252-62. doi: 10.1161/CIRCRESAHA.109.209940. Epub 2010 Jun 3.

11.

Somatic mutations in pulmonary arterial hypertension: primary or secondary events?

Austin ED, Hamid R, Ahmad F.

Am J Respir Crit Care Med. 2010 Nov 1;182(9):1094-6. doi: 10.1164/rccm.201007-1147ED. No abstract available.

PMID:
21041561
12.

Investigation of second genetic hits at the BMPR2 locus as a modulator of disease progression in familial pulmonary arterial hypertension.

Machado RD, James V, Southwood M, Harrison RE, Atkinson C, Stewart S, Morrell NW, Trembath RC, Aldred MA.

Circulation. 2005 Feb 8;111(5):607-13.

13.

Evidence of dysfunction of endothelial progenitors in pulmonary arterial hypertension.

Toshner M, Voswinckel R, Southwood M, Al-Lamki R, Howard LS, Marchesan D, Yang J, Suntharalingam J, Soon E, Exley A, Stewart S, Hecker M, Zhu Z, Gehling U, Seeger W, Pepke-Zaba J, Morrell NW.

Am J Respir Crit Care Med. 2009 Oct 15;180(8):780-7. doi: 10.1164/rccm.200810-1662OC. Epub 2009 Jul 23.

14.

Proteomic analysis implicates translationally controlled tumor protein as a novel mediator of occlusive vascular remodeling in pulmonary arterial hypertension.

Lavoie JR, Ormiston ML, Perez-Iratxeta C, Courtman DW, Jiang B, Ferrer E, Caruso P, Southwood M, Foster WS, Morrell NW, Stewart DJ.

Circulation. 2014 May 27;129(21):2125-35. doi: 10.1161/CIRCULATIONAHA.114.008777. Epub 2014 Mar 21.

15.

Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension.

Yang X, Long L, Southwood M, Rudarakanchana N, Upton PD, Jeffery TK, Atkinson C, Chen H, Trembath RC, Morrell NW.

Circ Res. 2005 May 27;96(10):1053-63. Epub 2005 Apr 21.

16.

Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells.

Awad KS, Elinoff JM, Wang S, Gairhe S, Ferreyra GA, Cai R, Sun J, Solomon MA, Danner RL.

Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15;310(2):L187-201. doi: 10.1152/ajplung.00303.2015. Epub 2015 Nov 20.

17.

Loss of bone morphogenetic protein receptor 2 is associated with abnormal DNA repair in pulmonary arterial hypertension.

Li M, Vattulainen S, Aho J, Orcholski M, Rojas V, Yuan K, Helenius M, Taimen P, Myllykangas S, De Jesus Perez V, Koskenvuo JW, Alastalo TP.

Am J Respir Cell Mol Biol. 2014 Jun;50(6):1118-28. doi: 10.1165/rcmb.2013-0349OC.

PMID:
24433082
18.

Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension.

West JD, Carrier EJ, Bloodworth NC, Schroer AK, Chen P, Ryzhova LM, Gladson S, Shay S, Hutcheson JD, Merryman WD.

PLoS One. 2016 Feb 10;11(2):e0148657. doi: 10.1371/journal.pone.0148657. eCollection 2016.

19.

Involvement of the bone morphogenetic protein system in endothelin- and aldosterone-induced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension.

Yamanaka R, Otsuka F, Nakamura K, Yamashita M, Otani H, Takeda M, Matsumoto Y, Kusano KF, Ito H, Makino H.

Hypertens Res. 2010 May;33(5):435-45. doi: 10.1038/hr.2010.16. Epub 2010 Feb 26.

PMID:
20186146
20.

miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling.

Yang S, Banerjee S, Freitas Ad, Cui H, Xie N, Abraham E, Liu G.

Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15;302(6):L521-9. doi: 10.1152/ajplung.00316.2011. Epub 2012 Jan 6.

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