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Items: 1 to 20 of 89

1.

The pthaladyns: GTP competitive inhibitors of dynamin I and II GTPase derived from virtual screening.

Odell LR, Howan D, Gordon CP, Robertson MJ, Chau N, Mariana A, Whiting AE, Abagyan R, Daniel JA, Gorgani NN, Robinson PJ, McCluskey A.

J Med Chem. 2010 Jul 22;53(14):5267-80. doi: 10.1021/jm100442u.

PMID:
20575553
2.

Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis.

Hill TA, Mariana A, Gordon CP, Odell LR, Robertson MJ, McGeachie AB, Chau N, Daniel JA, Gorgani NN, Robinson PJ, McCluskey A.

J Med Chem. 2010 May 27;53(10):4094-102. doi: 10.1021/jm100119c.

PMID:
20426422
3.
4.

Some selective serotonin reuptake inhibitors inhibit dynamin I guanosine triphosphatase (GTPase).

Otomo M, Takahashi K, Miyoshi H, Osada K, Nakashima H, Yamaguchi N.

Biol Pharm Bull. 2008 Aug;31(8):1489-95.

5.

Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles.

Hill TA, Gordon CP, McGeachie AB, Venn-Brown B, Odell LR, Chau N, Quan A, Mariana A, Sakoff JA, Chircop M, Robinson PJ, McCluskey A.

J Med Chem. 2009 Jun 25;52(12):3762-73. doi: 10.1021/jm900036m.

PMID:
19459681
6.

Increased GTP-binding to dynamin II does not stimulate receptor-mediated endocytosis.

Jeong MJ, Yoo J, Lee SS, Lee KI, Cho A, Kwon BM, Moon MJ, Park YM, Han MY.

Biochem Biophys Res Commun. 2001 Apr 27;283(1):136-42.

PMID:
11322780
7.

Suppression of dynamin GTPase activity by sertraline leads to inhibition of dynamin-dependent endocytosis.

Takahashi K, Miyoshi H, Otomo M, Osada K, Yamaguchi N, Nakashima H.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):382-7. doi: 10.1016/j.bbrc.2009.11.067.

PMID:
19913505
8.

The mechanism of GTP hydrolysis by dynamin II: a transient kinetic study.

Binns DD, Helms MK, Barylko B, Davis CT, Jameson DM, Albanesi JP, Eccleston JF.

Biochemistry. 2000 Jun 20;39(24):7188-96.

PMID:
10852717
9.

Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II.

Quan A, McGeachie AB, Keating DJ, van Dam EM, Rusak J, Chau N, Malladi CS, Chen C, McCluskey A, Cousin MA, Robinson PJ.

Mol Pharmacol. 2007 Dec;72(6):1425-39.

11.

Development of second-generation indole-based dynamin GTPase inhibitors.

Gordon CP, Venn-Brown B, Robertson MJ, Young KA, Chau N, Mariana A, Whiting A, Chircop M, Robinson PJ, McCluskey A.

J Med Chem. 2013 Jan 10;56(1):46-59. doi: 10.1021/jm300844m.

PMID:
23167654
12.

GTPase activity of dynamin and resulting conformation change are essential for endocytosis.

Marks B, Stowell MH, Vallis Y, Mills IG, Gibson A, Hopkins CR, McMahon HT.

Nature. 2001 Mar 8;410(6825):231-5.

PMID:
11242086
13.

Domain structure and intramolecular regulation of dynamin GTPase.

Muhlberg AB, Warnock DE, Schmid SL.

EMBO J. 1997 Nov 17;16(22):6676-83.

14.

1,8-Naphthalimide derivatives: new leads against dynamin I GTPase activity.

Abdel-Hamid MK, Macgregor KA, Odell LR, Chau N, Mariana A, Whiting A, Robinson PJ, McCluskey A.

Org Biomol Chem. 2015 Aug 7;13(29):8016-28. doi: 10.1039/c5ob00751h.

PMID:
26118967
15.

Small molecule inhibitors of dynamin I GTPase activity: development of dimeric tyrphostins.

Hill T, Odell LR, Edwards JK, Graham ME, McGeachie AB, Rusak J, Quan A, Abagyan R, Scott JL, Robinson PJ, McCluskey A.

J Med Chem. 2005 Dec 1;48(24):7781-8.

PMID:
16302817
16.

The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.

Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, Ryu SH.

Nat Cell Biol. 2006 May;8(5):477-84.

PMID:
16622417
17.

Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring.

Stowell MH, Marks B, Wigge P, McMahon HT.

Nat Cell Biol. 1999 May;1(1):27-32.

PMID:
10559860
18.

Calcineurin inhibition of dynamin I GTPase activity coupled to nerve terminal depolarization.

Liu JP, Sim AT, Robinson PJ.

Science. 1994 Aug 12;265(5174):970-3.

PMID:
8052858
19.

Development of quinone analogues as dynamin GTPase inhibitors.

MacGregor KA, Abdel-Hamid MK, Odell LR, Chau N, Whiting A, Robinson PJ, McCluskey A.

Eur J Med Chem. 2014 Oct 6;85:191-206. doi: 10.1016/j.ejmech.2014.06.070.

PMID:
25084145
20.

Physical and functional connection between auxilin and dynamin during endocytosis.

Sever S, Skoch J, Newmyer S, Ramachandran R, Ko D, McKee M, Bouley R, Ausiello D, Hyman BT, Bacskai BJ.

EMBO J. 2006 Sep 20;25(18):4163-74.

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