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Items: 1 to 20 of 86


Glutamine addiction: a new therapeutic target in cancer.

Wise DR, Thompson CB.

Trends Biochem Sci. 2010 Aug;35(8):427-33. doi: 10.1016/j.tibs.2010.05.003. Review.


Redox control of glutamine utilization in cancer.

Alberghina L, Gaglio D.

Cell Death Dis. 2014 Dec 4;5:e1561. doi: 10.1038/cddis.2014.513. Review.


Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis.

DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19345-50. Epub 2007 Nov 21.


Amino acid management in cancer.

Tsun ZY, Possemato R.

Semin Cell Dev Biol. 2015 Jul;43:22-32. doi: 10.1016/j.semcdb.2015.08.002. Epub 2015 Aug 12. Review.


Reductive carboxylation supports growth in tumour cells with defective mitochondria.

Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, DeBerardinis RJ.

Nature. 2011 Nov 20;481(7381):385-8. doi: 10.1038/nature10642.


Mitochondrial metabolism and cancer.

Weinberg F, Chandel NS.

Ann N Y Acad Sci. 2009 Oct;1177:66-73. doi: 10.1111/j.1749-6632.2009.05039.x. Review.


Hopefully devoted to Q: targeting glutamine addiction in cancer.

Still ER, Yuneva MO.

Br J Cancer. 2017 May 23;116(11):1375-1381. doi: 10.1038/bjc.2017.113. Epub 2017 Apr 25. Review.


Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.

Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, Thompson CB.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18782-7. doi: 10.1073/pnas.0810199105. Epub 2008 Nov 24.


The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.

Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, Blenis J.

Cell. 2013 May 9;153(4):840-54. doi: 10.1016/j.cell.2013.04.023.


Glutaminolysis: supplying carbon or nitrogen or both for cancer cells?

Dang CV.

Cell Cycle. 2010 Oct 1;9(19):3884-6. Epub 2010 Oct 9.


Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment.

Tanaka K, Sasayama T, Irino Y, Takata K, Nagashima H, Satoh N, Kyotani K, Mizowaki T, Imahori T, Ejima Y, Masui K, Gini B, Yang H, Hosoda K, Sasaki R, Mischel PS, Kohmura E.

J Clin Invest. 2015 Apr;125(4):1591-602. doi: 10.1172/JCI78239. Epub 2015 Mar 23.


Mitochondrial metabolism inhibitors for cancer therapy.

Ramsay EE, Hogg PJ, Dilda PJ.

Pharm Res. 2011 Nov;28(11):2731-44. doi: 10.1007/s11095-011-0584-5. Epub 2011 Sep 15. Review.


Metabolic alterations in cancer cells and therapeutic implications.

Hammoudi N, Ahmed KB, Garcia-Prieto C, Huang P.

Chin J Cancer. 2011 Aug;30(8):508-25. doi: 10.5732/cjc.011.10267. Review.


Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia.

Willems L, Jacque N, Jacquel A, Neveux N, Maciel TT, Lambert M, Schmitt A, Poulain L, Green AS, Uzunov M, Kosmider O, Radford-Weiss I, Moura IC, Auberger P, Ifrah N, Bardet V, Chapuis N, Lacombe C, Mayeux P, Tamburini J, Bouscary D.

Blood. 2013 Nov 14;122(20):3521-32. doi: 10.1182/blood-2013-03-493163. Epub 2013 Sep 6.


Bidirectional transport of amino acids regulates mTOR and autophagy.

Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, Yang H, Hild M, Kung C, Wilson C, Myer VE, MacKeigan JP, Porter JA, Wang YK, Cantley LC, Finan PM, Murphy LO.

Cell. 2009 Feb 6;136(3):521-34. doi: 10.1016/j.cell.2008.11.044.


Glutaminolysis: A Hallmark of Cancer Metabolism.

Yang L, Venneti S, Nagrath D.

Annu Rev Biomed Eng. 2017 Jun 21;19:163-194. doi: 10.1146/annurev-bioeng-071516-044546. Epub 2017 Mar 8. Review.


Glutamine and cancer: cell biology, physiology, and clinical opportunities.

Hensley CT, Wasti AT, DeBerardinis RJ.

J Clin Invest. 2013 Sep;123(9):3678-84. doi: 10.1172/JCI69600. Epub 2013 Sep 3. Review.


The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation.

Csibi A, Lee G, Yoon SO, Tong H, Ilter D, Elia I, Fendt SM, Roberts TM, Blenis J.

Curr Biol. 2014 Oct 6;24(19):2274-80. doi: 10.1016/j.cub.2014.08.007. Epub 2014 Sep 11.


Amino acid signaling through the mammalian target of rapamycin (mTOR) pathway: Role of glutamine and of cell shrinkage.

Fumarola C, La Monica S, Guidotti GG.

J Cell Physiol. 2005 Jul;204(1):155-65.


Tumor cell metabolism: an integral view.

Romero-Garcia S, Lopez-Gonzalez JS, Báez-Viveros JL, Aguilar-Cazares D, Prado-Garcia H.

Cancer Biol Ther. 2011 Dec 1;12(11):939-48. doi: 10.4161/cbt.12.11.18140. Epub 2011 Dec 1. Review.

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