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Intracellular Casp8p41 content is inversely associated with CD4 T cell count.

Cummins NW, Jiang W, McGinty J, Bren GD, Bosch RJ, Landay A, Deeks SG, Martin JN, Douek D, Lederman MM, Brenchley J, Badley AD.

J Infect Dis. 2010 Aug 15;202(3):386-91. doi: 10.1086/653705.


Short communication: CD4 T cell declines occurring during suppressive antiretroviral therapy reflect continued production of Casp8p41.

Cummins NW, Neuhaus J, Sainski AM, Strausbauch MA, Wettstein PJ, Lewin SR, Plana M, Rizza SA, Temesgen Z, Touloumi G, Freiberg M, Neaton J, Badley AD; INSIGHT SMART Study Group..

AIDS Res Hum Retroviruses. 2014 May;30(5):476-9. doi: 10.1089/AID.2013.0243.


Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size.

Cummins NW, Sainski AM, Dai H, Natesampillai S, Pang YP, Bren GD, de Araujo Correia MC, Sampath R, Rizza SA, O'Brien D, Yao JD, Kaufmann SH, Badley AD.

J Virol. 2016 Mar 28;90(8):4032-48. doi: 10.1128/JVI.03179-15.


Human immunodeficiency virus type 1 protease cleaves procaspase 8 in vivo.

Nie Z, Bren GD, Vlahakis SR, Schimnich AA, Brenchley JM, Trushin SA, Warren S, Schnepple DJ, Kovacs CM, Loutfy MR, Douek DC, Badley AD.

J Virol. 2007 Jul;81(13):6947-56.


Casp8p41 expression in primary T cells induces a proinflammatory response.

Taylor JA, Cummins NW, Bren GD, Rizza SA, Kolbert CP, Behrens MD, Knutson KL, Kahl JC, Asmann YW, Badley AD.

AIDS. 2010 Jun 1;24(9):1251-8. doi: 10.1097/QAD.0b013e3283389e90.


Programmed death-1 expression on CD4⁺ and CD8⁺ T cells in treated and untreated HIV disease.

Cockerham LR, Jain V, Sinclair E, Glidden DV, Hartogenesis W, Hatano H, Hunt PW, Martin JN, Pilcher CD, Sekaly R, McCune JM, Hecht FM, Deeks SG.

AIDS. 2014 Jul 31;28(12):1749-58. doi: 10.1097/QAD.0000000000000314.


Combined Env- and Gag-specific T cell responses in relation to programmed death-1 receptor and CD4 T cell loss rates in human immunodeficiency virus-1 infection.

Pettersen FO, Taskén K, Kvale D.

Clin Exp Immunol. 2010 Aug;161(2):315-23. doi: 10.1111/j.1365-2249.2010.04179.x.


[Characteristics of immunophenotypic alterations in 263 HIV/AIDS patients].

Xie J, Qiu ZF, Li TS, Han Y, Zuo LY, Ma XJ, Liu ZY, Wang AX.

Zhonghua Yi Xue Za Zhi. 2006 Apr 11;86(14):965-9. Chinese.


T cell activation in HIV-seropositive Ugandans: differential associations with viral load, CD4+ T cell depletion, and coinfection.

Eggena MP, Barugahare B, Okello M, Mutyala S, Jones N, Ma Y, Kityo C, Mugyenyi P, Cao H.

J Infect Dis. 2005 Mar 1;191(5):694-701.


Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 T cell recovery in virologically suppressed HIV-infected patients: clinical implications.

Negredo E, Massanella M, Puig J, Pérez-Alvarez N, Gallego-Escuredo JM, Villarroya J, Villarroya F, Moltó J, Santos JR, Clotet B, Blanco J.

Clin Infect Dis. 2010 May 1;50(9):1300-8. doi: 10.1086/651689.


Close association of CD8+/CD38 bright with HIV-1 replication and complex relationship with CD4+ T-cell count.

Tuaillon E, Al Tabaa Y, Baillat V, Segondy M, Picot MC, Reynes J, Vendrell JP.

Cytometry B Clin Cytom. 2009 Jul;76(4):249-60. doi: 10.1002/cyto.b.20467.


Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa.

Brumme Z, Wang B, Nair K, Brumme C, de Pierres C, Reddy S, Julg B, Moodley E, Thobakgale C, Lu Z, van der Stok M, Bishop K, Mncube Z, Chonco F, Yuki Y, Frahm N, Brander C, Carrington M, Freedberg K, Kiepiela P, Goulder P, Walker B, Ndung'u T, Losina E.

Clin Infect Dis. 2009 Sep 15;49(6):956-64. doi: 10.1086/605503.


Absolute CD4+ T-lymphocyte count as a surrogate marker of pediatric human immunodeficiency virus disease progression.

Paintsil E, Ghebremichael M, Romano S, Andiman WA.

Pediatr Infect Dis J. 2008 Jul;27(7):629-35. doi: 10.1097/INF.0b013e3181693892.


Magnitude and complexity of rectal mucosa HIV-1-specific CD8+ T-cell responses during chronic infection reflect clinical status.

Critchfield JW, Young DH, Hayes TL, Braun JV, Garcia JC, Pollard RB, Shacklett BL.

PLoS One. 2008;3(10):e3577. doi: 10.1371/journal.pone.0003577.


Regeneration and tolerance factor: a correlate of human immunodeficiency virus-associated T-cell activation.

Givens TS, DuChateau BK, Boomer JS, Westerman MP, Gilman-Sachs A, Beaman KD.

Clin Diagn Lab Immunol. 1999 Nov;6(6):872-7.


Positive association between beta-chemokine-producing T cells and HIV type 1 viral load in HIV-infected subjects in Abidjan, Côte d'Ivoire.

Jennes W, Sawadogo S, Koblavi-Dème S, Vuylsteke B, Maurice C, Roels TH, Chorba T, Nkengasong JN, Kestens L.

AIDS Res Hum Retroviruses. 2002 Feb 10;18(3):171-7.


HIV-1-specific cytolytic T-lymphocyte activity correlates with lower viral load, higher CD4 count, and CD8+CD38-DR- phenotype: comparison of statistical methods for measurement.

Lubaki NM, Shepherd ME, Brookmeyer RS, Hon H, Quinn TC, Kashamuka M, Johnson M, Gottle R, Devers J, Lederman HM, Bollinger RC.

J Acquir Immune Defic Syndr. 1999 Sep 1;22(1):19-30.


Residual HIV-specific CD4 and CD8 T cell frequencies after prolonged antiretroviral therapy reflect pretreatment plasma virus load.

Oxenius A, Price DA, Dawson SJ, Günthard HF, Fischer M, Perrin L, Ramirez E, Fagard C, Hirschel B, Scullard G, Weber JN, McLean AR, Phillips RE; Swiss HIV cohort study..

AIDS. 2002 Nov 22;16(17):2317-22.


The HIV-1-specific protein Casp8p41 induces death of infected cells through Bax/Bak.

Sainski AM, Natesampillai S, Cummins NW, Bren GD, Taylor J, Saenz DT, Poeschla EM, Badley AD.

J Virol. 2011 Aug;85(16):7965-75. doi: 10.1128/JVI.02515-10.

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