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Items: 1 to 20 of 146

1.

The role of tau in Alzheimer's disease and related disorders.

Medeiros R, Baglietto-Vargas D, LaFerla FM.

CNS Neurosci Ther. 2011 Oct;17(5):514-24. doi: 10.1111/j.1755-5949.2010.00177.x. Epub 2010 Jun 14. Review.

2.

Tau pathology in Alzheimer disease and other tauopathies.

Iqbal K, Alonso Adel C, Chen S, Chohan MO, El-Akkad E, Gong CX, Khatoon S, Li B, Liu F, Rahman A, Tanimukai H, Grundke-Iqbal I.

Biochim Biophys Acta. 2005 Jan 3;1739(2-3):198-210. Review.

3.

Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion.

Iqbal K, Alonso Adel C, El-Akkad E, Gong CX, Haque N, Khatoon S, Pei JJ, Tsujio I, Wang JZ, Grundke-Iqbal I.

J Mol Neurosci. 2002 Aug-Oct;19(1-2):95-9. Review.

PMID:
12212801
4.

Tau in Alzheimer disease and related tauopathies.

Iqbal K, Liu F, Gong CX, Grundke-Iqbal I.

Curr Alzheimer Res. 2010 Dec;7(8):656-64. Review.

5.

Mechanisms of tau-induced neurodegeneration.

Iqbal K, Liu F, Gong CX, Alonso Adel C, Grundke-Iqbal I.

Acta Neuropathol. 2009 Jul;118(1):53-69. doi: 10.1007/s00401-009-0486-3. Epub 2009 Jan 30. Review.

6.

Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration.

Wang JZ, Grundke-Iqbal I, Iqbal K.

Eur J Neurosci. 2007 Jan;25(1):59-68.

7.

Molecular mechanism of Alzheimer's neurofibrillary degeneration and therapeutic intervention.

Iqbal K, Grundke-Iqbal I.

Ann N Y Acad Sci. 1996 Jan 17;777:132-8. Review.

PMID:
8624075
8.

[The microtubule-associated protein tau in neurodegenerative diseases. Tauopathies].

Sánchez MP, Alvarez-Tallada V, Avila J.

Rev Neurol. 2001 Jul 16-31;33(2):169-77. Review. Spanish.

PMID:
11562878
9.

Alzheimer neurofibrillary degeneration: therapeutic targets and high-throughput assays.

Iqbal K, Alonso Adel C, El-Akkad E, Gong CX, Haque N, Khatoon S, Pei JJ, Tanimukai H, Tsujio I, Wang JZ, Grundke-Iqba I.

J Mol Neurosci. 2003;20(3):425-9. Review.

PMID:
14501027
10.

Tau as a therapeutic target for Alzheimer's disease.

Boutajangout A, Sigurdsson EM, Krishnamurthy PK.

Curr Alzheimer Res. 2011 Sep;8(6):666-77. Review.

11.

Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors.

Brunden KR, Ballatore C, Crowe A, Smith AB 3rd, Lee VM, Trojanowski JQ.

Exp Neurol. 2010 Jun;223(2):304-10. doi: 10.1016/j.expneurol.2009.08.031. Epub 2009 Sep 8. Review.

12.
13.

Mechanisms of tau self-aggregation and neurotoxicity.

Farías G, Cornejo A, Jiménez J, Guzmán L, Maccioni RB.

Curr Alzheimer Res. 2011 Sep;8(6):608-14. Review.

PMID:
21605046
14.

Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity.

Alonso Adel C, Li B, Grundke-Iqbal I, Iqbal K.

Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8864-9. Epub 2006 May 30.

15.

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments.

Alonso A, Zaidi T, Novak M, Grundke-Iqbal I, Iqbal K.

Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6923-8. Epub 2001 May 29.

16.

Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles.

Iqbal K, Alonso AC, Gong CX, Khatoon S, Pei JJ, Wang JZ, Grundke-Iqbal I.

J Neural Transm Suppl. 1998;53:169-80. Review.

PMID:
9700655
17.

Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration.

Wang JZ, Xia YY, Grundke-Iqbal I, Iqbal K.

J Alzheimers Dis. 2013;33 Suppl 1:S123-39. Review.

PMID:
22710920
18.
19.

The role of tau kinases in Alzheimer's disease.

Dolan PJ, Johnson GV.

Curr Opin Drug Discov Devel. 2010 Sep;13(5):595-603. Review.

20.

Mechanism of neurofibrillary degeneration and pharmacologic therapeutic approach.

Iqbal K, Alonso AD, Gondal JA, Gong CX, Haque N, Khatoon S, Sengupta A, Wang JZ, Grundke-Iqbal I.

J Neural Transm Suppl. 2000;59:213-22. Review.

PMID:
10961432

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