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SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis.

Puneet P, Yap CT, Wong L, Lam Y, Koh DR, Moochhala S, Pfeilschifter J, Huwiler A, Melendez AJ.

Science. 2010 Jun 4;328(5983):1290-4. doi: 10.1126/science.1188635. Erratum in: Science. 2011 Jan 14;331(6014):147. Retraction in: Puneet P, Yap CT, Wong L, Yulin L, Koh DR, Moochhala S, Pfeilschifter J, Huwiler A. Science. 2013 Jul 26;341(6144):342.


Editorial expression of concern.

Alberts B.

Science. 2011 Oct 21;334(6054):310. doi: 10.1126/science.334.6054.310-a. No abstract available.


Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia.

Nayak D, Huo Y, Kwang WX, Pushparaj PN, Kumar SD, Ling EA, Dheen ST.

Neuroscience. 2010 Mar 10;166(1):132-44. doi: 10.1016/j.neuroscience.2009.12.020. Epub 2009 Dec 28.


Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin.

Bachmaier K, Guzman E, Kawamura T, Gao X, Malik AB.

PLoS One. 2012;7(2):e30742. doi: 10.1371/journal.pone.0030742. Epub 2012 Feb 15.


A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury.

Di A, Kawamura T, Gao XP, Tang H, Berdyshev E, Vogel SM, Zhao YY, Sharma T, Bachmaier K, Xu J, Malik AB.

J Biol Chem. 2010 May 21;285(21):15848-57. doi: 10.1074/jbc.M109.075549. Epub 2010 Mar 18.


n-3 Polyunsaturated Fatty Acids Improve Inflammation via Inhibiting Sphingosine Kinase 1 in a Rat Model of Parenteral Nutrition and CLP-Induced Sepsis.

Tian T, Zhao Y, Huang Q, Li J.

Lipids. 2016 Mar;51(3):271-8. doi: 10.1007/s11745-016-4129-x. Epub 2016 Feb 8.


Neither Fas ligand nor endotoxin is responsible for inducible peritoneal phagocyte apoptosis during sepsis/peritonitis.

Chung CS, Song GY, Moldawer LL, Chaudry IH, Ayala A.

J Surg Res. 2000 Jun 15;91(2):147-53.


Resveratrol attenuates C5a-induced inflammatory responses in vitro and in vivo by inhibiting phospholipase D and sphingosine kinase activities.

Issuree PD, Pushparaj PN, Pervaiz S, Melendez AJ.

FASEB J. 2009 Aug;23(8):2412-24. doi: 10.1096/fj.09-130542. Epub 2009 Apr 3.


CCR9+ macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsis.

Mizukami T, Kanai T, Mikami Y, Hayashi A, Doi T, Handa T, Matsumoto A, Jun L, Matsuoka K, Sato T, Hisamatsu T, Hibi T.

Immunol Lett. 2012 Sep;147(1-2):75-9. doi: 10.1016/j.imlet.2012.06.006. Epub 2012 Jul 4.


Cutting edge: bacterial lipoprotein induces endotoxin-independent tolerance to septic shock.

Wang JH, Doyle M, Manning BJ, Blankson S, Wu QD, Power C, Cahill R, Redmond HP.

J Immunol. 2003 Jan 1;170(1):14-8.


Sphingosine kinase‑1 mediates endotoxemia‑induced hyperinflammation in aged animals.

Lufrano M, Jacob A, Zhou M, Wang P.

Mol Med Rep. 2013 Aug;8(2):645-9. doi: 10.3892/mmr.2013.1562. Epub 2013 Jun 28.


Stopping sepsis by targeting sphingosine kinase 1.

O'Neill LA.

Sci Transl Med. 2010 Jun 16;2(36):36ps29. doi: 10.1126/scitranslmed.3001299.


Essential involvement of CX3CR1-mediated signals in the bactericidal host defense during septic peritonitis.

Ishida Y, Hayashi T, Goto T, Kimura A, Akimoto S, Mukaida N, Kondo T.

J Immunol. 2008 Sep 15;181(6):4208-18.


Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching.

Kim EY, Sturgill JL, Hait NC, Avni D, Valencia EC, Maceyka M, Lima S, Allegood J, Huang WC, Zhang S, Milstien S, Conrad D, Spiegel S.

FASEB J. 2014 Oct;28(10):4347-58. doi: 10.1096/fj.14-251611. Epub 2014 Jul 1.


AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose.

Huang K, Huang J, Chen C, Hao J, Wang S, Huang J, Liu P, Huang H.

Cell Signal. 2014 Mar;26(3):629-38. doi: 10.1016/j.cellsig.2013.12.002. Epub 2013 Dec 14.


Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis.

Zingarelli B, Piraino G, Hake PW, O'Connor M, Denenberg A, Fan H, Cook JA.

Am J Pathol. 2010 Oct;177(4):1834-47. doi: 10.2353/ajpath.2010.091010. Epub 2010 Aug 13.


Sphingosine kinase-1 mediates TNF-alpha-induced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flow.

Chen XL, Grey JY, Thomas S, Qiu FH, Medford RM, Wasserman MA, Kunsch C.

Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1452-8. Epub 2004 Jun 10.


NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.

Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C, Göktuna SI, Neuenhahn M, Fierer J, Paxian S, Van Rooijen N, Xu Y, O'Cain T, Jaffee BB, Busch DH, Duyster J, Schmid RM, Eckmann L, Karin M.

Cell. 2007 Sep 7;130(5):918-31.

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