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Items: 1 to 20 of 132

1.

Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.

Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, Yu X, Wuertzer CA, Hou H, Chiba S, Yamanouchi K, Leissring M, Petrucelli L, Nishihara M, Hutton ML, McGowan E, Dickson DW, Lewis J.

Am J Pathol. 2010 Jul;177(1):311-24. doi: 10.2353/ajpath.2010.090915. Epub 2010 Jun 3. Erratum in: Am J Pathol. 2010 Oct;177(4):2146. Wuertzer, Charles A [added].

2.

Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.

Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, Haass C, Capell A.

Acta Neuropathol. 2014;127(6):845-60. doi: 10.1007/s00401-014-1262-6. Epub 2014 Mar 12.

PMID:
24619111
3.

Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice.

Tanaka Y, Chambers JK, Matsuwaki T, Yamanouchi K, Nishihara M.

Acta Neuropathol Commun. 2014 Jul 15;2:78. doi: 10.1186/s40478-014-0078-x.

4.

Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.

Ward ME, Chen R, Huang HY, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P, Gelfand JM, Cruz-Herranz A, Cordano C, Alavi MV, Leslie S, Seeley WW, Miller BL, Bigio E, Mesulam MM, Bogyo MS, Mackenzie IR, Staropoli JF, Cotman SL, Huang EJ, Gan L, Green AJ.

Sci Transl Med. 2017 Apr 12;9(385). pii: eaah5642. doi: 10.1126/scitranslmed.aah5642.

5.

Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice.

Tanaka Y, Matsuwaki T, Yamanouchi K, Nishihara M.

Neuroscience. 2013 Oct 10;250:8-19. doi: 10.1016/j.neuroscience.2013.06.049. Epub 2013 Jul 2.

PMID:
23830905
6.

Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.

Holler CJ, Taylor G, McEachin ZT, Deng Q, Watkins WJ, Hudson K, Easley CA, Hu WT, Hales CM, Rossoll W, Bassell GJ, Kukar T.

Mol Neurodegener. 2016 Jun 24;11(1):46. doi: 10.1186/s13024-016-0114-3.

7.

Progranulin regulates neuronal outgrowth independent of sortilin.

Gass J, Lee WC, Cook C, Finch N, Stetler C, Jansen-West K, Lewis J, Link CD, Rademakers R, Nykjær A, Petrucelli L.

Mol Neurodegener. 2012 Jul 10;7:33. doi: 10.1186/1750-1326-7-33.

8.

Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice.

Petkau TL, Blanco J, Leavitt BR.

Neurobiol Dis. 2017 Oct;106:14-22. doi: 10.1016/j.nbd.2017.06.012. Epub 2017 Jun 21.

PMID:
28647554
9.

Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice.

Hafler BP, Klein ZA, Jimmy Zhou Z, Strittmatter SM.

Brain Res. 2014 Nov 7;1588:168-74. doi: 10.1016/j.brainres.2014.09.023. Epub 2014 Sep 16.

10.

Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.

Cenik B, Sephton CF, Kutluk Cenik B, Herz J, Yu G.

J Biol Chem. 2012 Sep 21;287(39):32298-306. Epub 2012 Aug 2. Review.

11.

Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice.

Wils H, Kleinberger G, Pereson S, Janssens J, Capell A, Van Dam D, Cuijt I, Joris G, De Deyn PP, Haass C, Van Broeckhoven C, Kumar-Singh S.

J Pathol. 2012 Sep;228(1):67-76. doi: 10.1002/path.4043. Epub 2012 Jun 25.

PMID:
22733568
12.

Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers.

Alquézar C, de la Encarnación A, Moreno F, López de Munain A, Martín-Requero Á.

J Psychiatry Neurosci. 2016 Jun;41(4):225-39.

13.

Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations.

Josephs KA, Ahmed Z, Katsuse O, Parisi JF, Boeve BF, Knopman DS, Petersen RC, Davies P, Duara R, Graff-Radford NR, Uitti RJ, Rademakers R, Adamson J, Baker M, Hutton ML, Dickson DW.

J Neuropathol Exp Neurol. 2007 Feb;66(2):142-51.

PMID:
17278999
14.

Core features of frontotemporal dementia recapitulated in progranulin knockout mice.

Ghoshal N, Dearborn JT, Wozniak DF, Cairns NJ.

Neurobiol Dis. 2012 Jan;45(1):395-408. doi: 10.1016/j.nbd.2011.08.029. Epub 2011 Sep 10.

15.

Disease and Region Specificity of Granulin Immunopositivities in Alzheimer Disease and Frontotemporal Lobar Degeneration.

Mao Q, Wang D, Li Y, Kohler M, Wilson J, Parton Z, Shmaltsuyeva B, Gursel D, Rademakers R, Weintraub S, Mesulam MM, Xia H, Bigio EH.

J Neuropathol Exp Neurol. 2017 Nov 1;76(11):957-968. doi: 10.1093/jnen/nlx085.

PMID:
29044416
16.

Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation.

Petkau TL, Kosior N, de Asis K, Connolly C, Leavitt BR.

J Neuroinflammation. 2017 Nov 17;14(1):225. doi: 10.1186/s12974-017-1000-9.

17.

Core neuropathological abnormalities in progranulin-deficient mice are penetrant on multiple genetic backgrounds.

Petkau TL, Hill A, Leavitt BR.

Neuroscience. 2016 Feb 19;315:175-95. doi: 10.1016/j.neuroscience.2015.12.006. Epub 2015 Dec 14.

PMID:
26701296
18.

Increased Wnt Signaling and Reduced Viability in a Neuronal Model of Progranulin-Deficient Frontotemporal Lobar Degeneration.

de la Encarnación A, Alquézar C, Martín-Requero Á.

Mol Neurobiol. 2016 Dec;53(10):7107-7118. Epub 2015 Dec 17.

PMID:
26676574
19.

Progranulin reduction is associated with increased tau phosphorylation in P301L tau transgenic mice.

Hosokawa M, Arai T, Masuda-Suzukake M, Kondo H, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H.

J Neuropathol Exp Neurol. 2015 Feb;74(2):158-65. doi: 10.1097/NEN.0000000000000158.

PMID:
25575133
20.

Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury.

Menzel L, Kleber L, Friedrich C, Hummel R, Dangel L, Winter J, Schmitz K, Tegeder I, Schäfer MK.

Glia. 2017 Feb;65(2):278-292. doi: 10.1002/glia.23091. Epub 2016 Oct 25.

PMID:
27778404

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