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Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme.

Panner A, Crane CA, Weng C, Feletti A, Fang S, Parsa AT, Pieper RO.

Cancer Res. 2010 Jun 15;70(12):5046-53. doi: 10.1158/0008-5472.CAN-09-3979. Epub 2010 May 18.


A novel PTEN-dependent link to ubiquitination controls FLIPS stability and TRAIL sensitivity in glioblastoma multiforme.

Panner A, Crane CA, Weng C, Feletti A, Parsa AT, Pieper RO.

Cancer Res. 2009 Oct 15;69(20):7911-6. doi: 10.1158/0008-5472.CAN-09-1287. Epub 2009 Oct 6.


USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability.

Jeong M, Lee EW, Seong D, Seo J, Kim JH, Grootjans S, Kim SY, Vandenabeele P, Song J.

Oncogene. 2017 Jan 26;36(4):458-470. doi: 10.1038/onc.2016.215. Epub 2016 Jun 20.


mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells.

Panner A, James CD, Berger MS, Pieper RO.

Mol Cell Biol. 2005 Oct;25(20):8809-23.


Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway.

Jung S, Li C, Jeong D, Lee S, Ohk J, Park M, Han S, Duan J, Kim C, Yang Y, Kim KI, Lim JS, Kang YS, Lee MS.

Int J Oncol. 2013 Nov;43(5):1587-95. doi: 10.3892/ijo.2013.2064. Epub 2013 Aug 20.


Temozolomide sensitizes stem-like cells of glioma spheres to TRAIL-induced apoptosis via upregulation of casitas B-lineage lymphoma (c-Cbl) protein.

Zhitao J, Long L, Jia L, Yunchao B, Anhua W.

Tumour Biol. 2015 Dec;36(12):9621-30. doi: 10.1007/s13277-015-3720-8. Epub 2015 Jul 6.


Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers.

Nam SY, Jung GA, Hur GC, Chung HY, Kim WH, Seol DW, Lee BL.

Cancer Sci. 2003 Dec;94(12):1066-73.


Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.

Malik R, Soh UJ, Trejo J, Marchese A.

J Biol Chem. 2012 Mar 16;287(12):9013-27. doi: 10.1074/jbc.M111.336792. Epub 2012 Jan 24.


Compound C sensitizes Caki renal cancer cells to TRAIL-induced apoptosis through reactive oxygen species-mediated down-regulation of c-FLIPL and Mcl-1.

Jang JH, Lee TJ, Yang ES, Min do S, Kim YH, Kim SH, Choi YH, Park JW, Choi KS, Kwon TK.

Exp Cell Res. 2010 Aug 1;316(13):2194-203. doi: 10.1016/j.yexcr.2010.04.028. Epub 2010 May 6.


Inhibition of c-FLIP by RNAi enhances sensitivity of the human osteogenic sarcoma cell line U2OS to TRAIL-induced apoptosis.

Zhang YP, Kong QH, Huang Y, Wang GL, Chang KJ.

Asian Pac J Cancer Prev. 2015;16(6):2251-6.


Cystatin B inhibition of TRAIL-induced apoptosis is associated with the protection of FLIP(L) from degradation by the E3 ligase itch in human melanoma cells.

Yang F, Tay KH, Dong L, Thorne RF, Jiang CC, Yang E, Tseng HY, Liu H, Christopherson R, Hersey P, Zhang XD.

Cell Death Differ. 2010 Aug;17(8):1354-67. doi: 10.1038/cdd.2010.29. Epub 2010 Mar 19.


USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin.

Durcan TM, Tang MY, Pérusse JR, Dashti EA, Aguileta MA, McLelland GL, Gros P, Shaler TA, Faubert D, Coulombe B, Fon EA.

EMBO J. 2014 Nov 3;33(21):2473-91. doi: 10.15252/embj.201489729. Epub 2014 Sep 12.


Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8.

Cai J, Crotty TM, Reichert E, Carraway KL 3rd, Stafforini DM, Topham MK.

J Biol Chem. 2010 Mar 5;285(10):6952-9. doi: 10.1074/jbc.M109.055731. Epub 2010 Jan 11.


The deubiquitinating enzyme USP8 promotes trafficking and degradation of the chemokine receptor 4 at the sorting endosome.

Berlin I, Higginbotham KM, Dise RS, Sierra MI, Nash PD.

J Biol Chem. 2010 Nov 26;285(48):37895-908. doi: 10.1074/jbc.M110.129411. Epub 2010 Sep 27.


Reciprocal cross-regulation between RNF41 and USP8 controls cytokine receptor sorting and processing.

De Ceuninck L, Wauman J, Masschaele D, Peelman F, Tavernier J.

J Cell Sci. 2013 Aug 15;126(Pt 16):3770-81. doi: 10.1242/jcs.131250. Epub 2013 Jun 7.


Regulation of epidermal growth factor receptor ubiquitination and trafficking by the USP8·STAM complex.

Berlin I, Schwartz H, Nash PD.

J Biol Chem. 2010 Nov 5;285(45):34909-21. doi: 10.1074/jbc.M109.016287. Epub 2010 Aug 24.


NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.

Eide PW, Cekaite L, Danielsen SA, Eilertsen IA, Kjenseth A, Fykerud TA, Ågesen TH, Bruun J, Rivedal E, Lothe RA, Leithe E.

Cell Signal. 2013 Jan;25(1):12-8. doi: 10.1016/j.cellsig.2012.08.012. Epub 2012 Sep 5.


Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein.

Abedini MR, Muller EJ, Bergeron R, Gray DA, Tsang BK.

Oncogene. 2010 Jan 7;29(1):11-25. doi: 10.1038/onc.2009.300. Epub 2009 Oct 5.


RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation.

Lee JT, Shan J, Zhong J, Li M, Zhou B, Zhou A, Parsons R, Gu W.

Cell Res. 2013 Apr;23(4):552-64. doi: 10.1038/cr.2013.27. Epub 2013 Feb 19.


α-TEA induces apoptosis of human breast cancer cells via activation of TRAIL/DR5 death receptor pathway.

Yu W, Tiwary R, Li J, Park SK, Jia L, Xiong A, Simmons-Menchaca M, Sanders BG, Kline K.

Mol Carcinog. 2010 Nov;49(11):964-73. doi: 10.1002/mc.20681.


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