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Items: 1 to 20 of 173


Efficacy of glutathione in ameliorating sulfur mustard analog-induced toxicity in cultured skin epidermal cells and in SKH-1 mouse skin in vivo.

Tewari-Singh N, Agarwal C, Huang J, Day BJ, White CW, Agarwal R.

J Pharmacol Exp Ther. 2011 Feb;336(2):450-9. doi: 10.1124/jpet.110.173708. Epub 2010 Oct 25. Review.


Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.

Shiotani B, Kobayashi M, Watanabe M, Yamamoto K, Sugimura T, Wakabayashi K.

Mol Cancer Res. 2006 Feb;4(2):125-33.


Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences.

Mangerich A, Debiak M, Birtel M, Ponath V, Balszuweit F, Lex K, Martello R, Burckhardt-Boer W, Strobelt R, Siegert M, Thiermann H, Steinritz D, Schmidt A, Bürkle A.

Toxicol Lett. 2016 Feb 26;244:56-71. doi: 10.1016/j.toxlet.2015.09.010. Epub 2015 Sep 14.


Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide-associated cutaneous toxic effects.

Tewari-Singh N, Inturi S, Jain AK, Agarwal C, Orlicky DJ, White CW, Agarwal R, Day BJ.

Free Radic Biol Med. 2014 Jul;72:285-95. doi: 10.1016/j.freeradbiomed.2014.04.022. Epub 2014 May 9.


Inflammatory biomarkers of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced skin injury in SKH-1 hairless mice.

Tewari-Singh N, Rana S, Gu M, Pal A, Orlicky DJ, White CW, Agarwal R.

Toxicol Sci. 2009 Mar;108(1):194-206. doi: 10.1093/toxsci/kfn261. Epub 2008 Dec 15.


Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents.

Haince JF, Kozlov S, Dawson VL, Dawson TM, Hendzel MJ, Lavin MF, Poirier GG.

J Biol Chem. 2007 Jun 1;282(22):16441-53. Epub 2007 Apr 11.


The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest.

Madison DL, Stauffer D, Lundblad JR.

DNA Repair (Amst). 2011 Oct 10;10(10):1003-13. doi: 10.1016/j.dnarep.2011.07.006. Epub 2011 Aug 12.


PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM.

Carrozza MJ, Stefanick DF, Horton JK, Kedar PS, Wilson SH.

DNA Repair (Amst). 2009 Nov 2;8(11):1264-72. doi: 10.1016/j.dnarep.2009.07.010. Epub 2009 Aug 31.


Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest.

Lundholm L, Hååg P, Zong D, Juntti T, Mörk B, Lewensohn R, Viktorsson K.

Cell Death Dis. 2013 Jan 31;4:e478. doi: 10.1038/cddis.2012.211.


Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest.

Yong W, Bao S, Chen H, Li D, Sánchez ER, Shou W.

J Biol Chem. 2007 May 18;282(20):14690-4. Epub 2007 Mar 21.


Immunochemical analysis of poly(ADP-ribosyl)ation in HaCaT keratinocytes induced by the mono-alkylating agent 2-chloroethyl ethyl sulfide (CEES): Impact of experimental conditions.

Debiak M, Lex K, Ponath V, Burckhardt-Boer W, Thiermann H, Steinritz D, Schmidt A, Mangerich A, Bürkle A.

Toxicol Lett. 2016 Feb 26;244:72-80. doi: 10.1016/j.toxlet.2015.09.009. Epub 2015 Sep 14.


ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress.

Myers K, Gagou ME, Zuazua-Villar P, Rodriguez R, Meuth M.

PLoS Genet. 2009 Jan;5(1):e1000324. doi: 10.1371/journal.pgen.1000324. Epub 2009 Jan 2.


S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11-induced apoptosis of prostate cancer cells.

Ray S, Shyam S, Fraizer GC, Almasan A.

Mol Cancer Ther. 2007 Apr;6(4):1368-78.


Etoposide induces G2/M arrest and apoptosis in neural progenitor cells via DNA damage and an ATM/p53-related pathway.

Nam C, Doi K, Nakayama H.

Histol Histopathol. 2010 Apr;25(4):485-93. doi: 10.14670/HH-25.485.


Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.

Lee AY, Chiba T, Truong LN, Cheng AN, Do J, Cho MJ, Chen L, Wu X.

J Biol Chem. 2012 Jan 20;287(4):2531-43. doi: 10.1074/jbc.M111.291104. Epub 2011 Nov 28.


Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1.

Yoon JH, Ahn SG, Lee BH, Jung SH, Oh SH.

Biochem Pharmacol. 2012 Mar 15;83(6):747-57. doi: 10.1016/j.bcp.2011.12.029. Epub 2011 Dec 29.


Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells.

Shin SY, Yong Y, Kim CG, Lee YH, Lim Y.

Cancer Lett. 2010 Jan 28;287(2):231-9. doi: 10.1016/j.canlet.2009.06.019. Epub 2009 Jul 17.


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