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A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions.

Yu T, Li Z, Jia Z, Clapcote SJ, Liu C, Li S, Asrar S, Pao A, Chen R, Fan N, Carattini-Rivera S, Bechard AR, Spring S, Henkelman RM, Stoica G, Matsui S, Nowak NJ, Roder JC, Chen C, Bradley A, Yu YE.

Hum Mol Genet. 2010 Jul 15;19(14):2780-91. doi: 10.1093/hmg/ddq179. Epub 2010 May 4.


Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.

Yu T, Liu C, Belichenko P, Clapcote SJ, Li S, Pao A, Kleschevnikov A, Bechard AR, Asrar S, Chen R, Fan N, Zhou Z, Jia Z, Chen C, Roder JC, Liu B, Baldini A, Mobley WC, Yu YE.

Brain Res. 2010 Dec 17;1366:162-71. doi: 10.1016/j.brainres.2010.09.107. Epub 2010 Oct 26.


Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits.

Zhang L, Meng K, Jiang X, Liu C, Pao A, Belichenko PV, Kleschevnikov AM, Josselyn S, Liang P, Ye P, Mobley WC, Yu YE.

Hum Mol Genet. 2014 Feb 1;23(3):578-89. doi: 10.1093/hmg/ddt446. Epub 2013 Sep 16.


Mouse models of Down syndrome: gene content and consequences.

Gupta M, Dhanasekaran AR, Gardiner KJ.

Mamm Genome. 2016 Dec;27(11-12):538-555. Epub 2016 Aug 18. Review.


Mouse models for Down syndrome-associated developmental cognitive disabilities.

Liu C, Belichenko PV, Zhang L, Fu D, Kleschevnikov AM, Baldini A, Antonarakis SE, Mobley WC, Yu YE.

Dev Neurosci. 2011;33(5):404-13. doi: 10.1159/000329422. Epub 2011 Aug 25. Review.


Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.

Belichenko PV, Kleschevnikov AM, Becker A, Wagner GE, Lysenko LV, Yu YE, Mobley WC.

PLoS One. 2015 Jul 31;10(7):e0134861. doi: 10.1371/journal.pone.0134861. eCollection 2015.


Down syndrome mouse models are looking up.

Reeves RH.

Trends Mol Med. 2006 Jun;12(6):237-40. Epub 2006 May 4.


Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome.

Morice E, Andreae LC, Cooke SF, Vanes L, Fisher EM, Tybulewicz VL, Bliss TV.

Learn Mem. 2008 Jul 14;15(7):492-500. doi: 10.1101/lm.969608. Print 2008 Jul.


Genetic analysis of Down syndrome-associated heart defects in mice.

Liu C, Morishima M, Yu T, Matsui S, Zhang L, Fu D, Pao A, Costa AC, Gardiner KJ, Cowell JK, Nowak NJ, Parmacek MS, Liang P, Baldini A, Yu YE.

Hum Genet. 2011 Nov;130(5):623-32. doi: 10.1007/s00439-011-0980-2. Epub 2011 Mar 26. Erratum in: Hum Genet. 2011 Nov;130(5):633. Nowak, Normal J [corrected to Nowak, Norma J].


Engineered chromosome-based genetic mapping establishes a 3.7 Mb critical genomic region for Down syndrome-associated heart defects in mice.

Liu C, Morishima M, Jiang X, Yu T, Meng K, Ray D, Pao A, Ye P, Parmacek MS, Yu YE.

Hum Genet. 2014 Jun;133(6):743-53. doi: 10.1007/s00439-013-1407-z. Epub 2013 Dec 22.


The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome.

Belichenko NP, Belichenko PV, Kleschevnikov AM, Salehi A, Reeves RH, Mobley WC.

J Neurosci. 2009 May 6;29(18):5938-48. doi: 10.1523/JNEUROSCI.1547-09.2009.


Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice.

Yu T, Clapcote SJ, Li Z, Liu C, Pao A, Bechard AR, Carattini-Rivera S, Matsui S, Roder JC, Baldini A, Mobley WC, Bradley A, Yu YE.

Mamm Genome. 2010 Jun;21(5-6):258-67. doi: 10.1007/s00335-010-9262-x. Epub 2010 May 29.


The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome.

Duchon A, Pothion S, Brault V, Sharp AJ, Tybulewicz VL, Fisher EM, Herault Y.

Behav Brain Res. 2011 Mar 1;217(2):271-81. doi: 10.1016/j.bbr.2010.10.023. Epub 2010 Oct 31.


Pathways to cognitive deficits in Down syndrome.

Sturgeon X, Le T, Ahmed MM, Gardiner KJ.

Prog Brain Res. 2012;197:73-100. doi: 10.1016/B978-0-444-54299-1.00005-4. Review.


Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice.

Roubertoux PL, Baril N, Cau P, Scajola C, Ghata A, Bartoli C, Bourgeois P, Christofaro JD, Tordjman S, Carlier M.

Behav Genet. 2017 May;47(3):305-322. doi: 10.1007/s10519-017-9835-5. Epub 2017 Feb 15. Erratum in: Behav Genet. 2017 May;47(3):323.


Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome.

Altafaj X, Martín ED, Ortiz-Abalia J, Valderrama A, Lao-Peregrín C, Dierssen M, Fillat C.

Neurobiol Dis. 2013 Apr;52:117-27. doi: 10.1016/j.nbd.2012.11.017. Epub 2012 Dec 5.


On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models.

Galdzicki Z, Siarey R, Pearce R, Stoll J, Rapoport SI.

Brain Res Brain Res Rev. 2001 Apr;35(2):115-45. Review.


Trisomy 21 and Down syndrome: a short review.

Sommer C, Henrique-Silva F.

Braz J Biol. 2008 May;68(2):447-52. Review.


Physical mapping of the evolutionary boundary between human chromosomes 21 and 22 on mouse chromosome 10.

Cole SE, Wiltshire T, Reeves RH.

Genomics. 1998 May 15;50(1):109-11.


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