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Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial.

Dangour AD, Allen E, Elbourne D, Fasey N, Fletcher AE, Hardy P, Holder GE, Knight R, Letley L, Richards M, Uauy R.

Am J Clin Nutr. 2010 Jun;91(6):1725-32. doi: 10.3945/ajcn.2009.29121. Epub 2010 Apr 21.


The n-3 Polyunsaturated Fatty Acids Supplementation Improved the Cognitive Function in the Chinese Elderly with Mild Cognitive Impairment: A Double-Blind Randomized Controlled Trial.

Bo Y, Zhang X, Wang Y, You J, Cui H, Zhu Y, Pang W, Liu W, Jiang Y, Lu Q.

Nutrients. 2017 Jan 10;9(1). pii: E54. doi: 10.3390/nu9010054.


An 18-mo randomized, double-blind, placebo-controlled trial of DHA-rich fish oil to prevent age-related cognitive decline in cognitively normal older adults.

Danthiir V, Hosking DE, Nettelbeck T, Vincent AD, Wilson C, O'Callaghan N, Calvaresi E, Clifton P, Wittert GA.

Am J Clin Nutr. 2018 May 1;107(5):754-762. doi: 10.1093/ajcn/nqx077.


Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial.

Andrieu S, Guyonnet S, Coley N, Cantet C, Bonnefoy M, Bordes S, Bories L, Cufi MN, Dantoine T, Dartigues JF, Desclaux F, Gabelle A, Gasnier Y, Pesce A, Sudres K, Touchon J, Robert P, Rouaud O, Legrand P, Payoux P, Caubere JP, Weiner M, Carrié I, Ousset PJ, Vellas B; MAPT Study Group.

Lancet Neurol. 2017 May;16(5):377-389. doi: 10.1016/S1474-4422(17)30040-6. Epub 2017 Mar 27.


Effect of low doses of long-chain n-3 PUFAs on endothelial function and arterial stiffness: a randomized controlled trial.

Sanders TA, Hall WL, Maniou Z, Lewis F, Seed PT, Chowienczyk PJ.

Am J Clin Nutr. 2011 Oct;94(4):973-80. doi: 10.3945/ajcn.111.018036. Epub 2011 Aug 24.


Long-chain PUFA supplementation in rural African infants: a randomized controlled trial of effects on gut integrity, growth, and cognitive development.

van der Merwe LF, Moore SE, Fulford AJ, Halliday KE, Drammeh S, Young S, Prentice AM.

Am J Clin Nutr. 2013 Jan;97(1):45-57. doi: 10.3945/ajcn.112.042267. Epub 2012 Dec 5.


Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial.

van de Rest O, Geleijnse JM, Kok FJ, van Staveren WA, Dullemeijer C, Olderikkert MG, Beekman AT, de Groot CP.

Neurology. 2008 Aug 5;71(6):430-8. doi: 10.1212/01.wnl.0000324268.45138.86.


Effects of n-3 fatty acids on cognitive decline: a randomized, double-blind, placebo-controlled trial in stable myocardial infarction patients.

Geleijnse JM, Giltay EJ, Kromhout D.

Alzheimers Dement. 2012 Jul;8(4):278-87. doi: 10.1016/j.jalz.2011.06.002. Epub 2011 Oct 2.


Effect of fish-oil supplementation on mental well-being in older subjects: a randomized, double-blind, placebo-controlled trial.

van de Rest O, Geleijnse JM, Kok FJ, van Staveren WA, Hoefnagels WH, Beekman AT, de Groot LC.

Am J Clin Nutr. 2008 Sep;88(3):706-13.


Compared with daily, weekly n-3 PUFA intake affects the incorporation of eicosapentaenoic acid and docosahexaenoic acid into platelets and mononuclear cells in humans.

Browning LM, Walker CG, Mander AP, West AL, Gambell J, Madden J, Calder PC, Jebb SA.

J Nutr. 2014 May;144(5):667-72. doi: 10.3945/jn.113.186346. Epub 2014 Mar 19.


Effects of iron and n-3 fatty acid supplementation, alone and in combination, on cognition in school children: a randomized, double-blind, placebo-controlled intervention in South Africa.

Baumgartner J, Smuts CM, Malan L, Kvalsvig J, van Stuijvenberg ME, Hurrell RF, Zimmermann MB.

Am J Clin Nutr. 2012 Dec;96(6):1327-38. doi: 10.3945/ajcn.112.041004. Epub 2012 Oct 24.


Omega 3 fatty acid for the prevention of cognitive decline and dementia.

Sydenham E, Dangour AD, Lim WS.

Cochrane Database Syst Rev. 2012 Jun 13;(6):CD005379. doi: 10.1002/14651858.CD005379.pub3. Review.


n-3 Long-chain PUFAs reduce respiratory morbidity caused by iron supplementation in iron-deficient South African schoolchildren: a randomized, double-blind, placebo-controlled intervention.

Malan L, Baumgartner J, Calder PC, Zimmermann MB, Smuts CM.

Am J Clin Nutr. 2015 Mar;101(3):668-79. doi: 10.3945/ajcn.113.081208. Epub 2014 Dec 31.


Similar eicosapentaenoic acid and docosahexaenoic acid plasma levels achieved with fish oil or krill oil in a randomized double-blind four-week bioavailability study.

Yurko-Mauro K, Kralovec J, Bailey-Hall E, Smeberg V, Stark JG, Salem N Jr.

Lipids Health Dis. 2015 Sep 2;14:99. doi: 10.1186/s12944-015-0109-z.


Ready-to-use therapeutic food with elevated n-3 polyunsaturated fatty acid content, with or without fish oil, to treat severe acute malnutrition: a randomized controlled trial.

Jones KD, Ali R, Khasira MA, Odera D, West AL, Koster G, Akomo P, Talbert AW, Goss VM, Ngari M, Thitiri J, Ndoro S, Knight MA, Omollo K, Ndungu A, Mulongo MM, Bahwere P, Fegan G, Warner JO, Postle AD, Collins S, Calder PC, Berkley JA.

BMC Med. 2015 Apr 23;13:93. doi: 10.1186/s12916-015-0315-6.


Polyunsaturated fatty acid supplementation for drug-resistant epilepsy.

Sarmento Vasconcelos V, Macedo CR, de Souza Pedrosa A, Pereira Gomes Morais E, Porfírio GJ, Torloni MR.

Cochrane Database Syst Rev. 2016 Aug 17;(8):CD011014. doi: 10.1002/14651858.CD011014.pub2. Review.


No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial.

Rogers PJ, Appleton KM, Kessler D, Peters TJ, Gunnell D, Hayward RC, Heatherley SV, Christian LM, McNaughton SA, Ness AR.

Br J Nutr. 2008 Feb;99(2):421-31. Epub 2007 Oct 24.


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