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Items: 1 to 20 of 100

1.

Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells.

Chadalapaka G, Jutooru I, Burghardt R, Safe S.

Mol Cancer Res. 2010 May;8(5):739-50. doi: 10.1158/1541-7786.MCR-09-0493. Epub 2010 Apr 20.

2.

Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs.

Gandhy SU, Kim K, Larsen L, Rosengren RJ, Safe S.

BMC Cancer. 2012 Nov 30;12:564. doi: 10.1186/1471-2407-12-564.

3.

Curcumin decreases specificity protein expression in bladder cancer cells.

Chadalapaka G, Jutooru I, Chintharlapalli S, Papineni S, Smith R 3rd, Li X, Safe S.

Cancer Res. 2008 Jul 1;68(13):5345-54. doi: 10.1158/0008-5472.CAN-07-6805.

4.
5.

Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.

Jutooru I, Chadalapaka G, Lei P, Safe S.

J Biol Chem. 2010 Aug 13;285(33):25332-44. doi: 10.1074/jbc.M109.095240. Epub 2010 Jun 9.

6.

Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10.

Mertens-Talcott SU, Noratto GD, Li X, Angel-Morales G, Bertoldi MC, Safe S.

Mol Carcinog. 2013 Aug;52(8):591-602. doi: 10.1002/mc.21893. Epub 2012 Mar 7.

7.

Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth.

Jutooru I, Chadalapaka G, Sreevalsan S, Lei P, Barhoumi R, Burghardt R, Safe S.

Exp Cell Res. 2010 Aug 1;316(13):2174-88. doi: 10.1016/j.yexcr.2010.04.027. Epub 2010 May 8.

8.

Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors.

Nair V, Sreevalsan S, Basha R, Abdelrahim M, Abudayyeh A, Rodrigues Hoffman A, Safe S.

J Biol Chem. 2014 Oct 3;289(40):27692-701. doi: 10.1074/jbc.M114.592576. Epub 2014 Aug 20.

9.

Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation.

Abdelrahim M, Baker CH, Abbruzzese JL, Safe S.

J Natl Cancer Inst. 2006 Jun 21;98(12):855-68.

PMID:
16788159
10.

Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid.

Qiu L, Wang Q, Di W, Jiang Q, Schefeller E, Derby S, Wanebo H, Yan B, Wan Y.

Int J Oncol. 2005 Sep;27(3):823-30.

PMID:
16077934
11.

Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells.

Chadalapaka G, Jutooru I, Safe S.

Carcinogenesis. 2012 Apr;33(4):886-94. doi: 10.1093/carcin/bgs102. Epub 2012 Feb 14.

12.

Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors.

Nair V, Pathi S, Jutooru I, Sreevalsan S, Basha R, Abdelrahim M, Samudio I, Safe S.

Carcinogenesis. 2013 Dec;34(12):2870-9. doi: 10.1093/carcin/bgt231. Epub 2013 Jun 26.

13.

Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors.

Chadalapaka G, Jutooru I, Sreevalsan S, Pathi S, Kim K, Chen C, Crose L, Linardic C, Safe S.

Int J Cancer. 2013 Feb 15;132(4):795-806. doi: 10.1002/ijc.27730. Epub 2012 Aug 3. Erratum in: Int J Cancer. 2015 Sep 15;137(6):E9.

14.

Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors.

Pathi S, Jutooru I, Chadalapaka G, Nair V, Lee SO, Safe S.

PLoS One. 2012;7(10):e48208. doi: 10.1371/journal.pone.0048208. Epub 2012 Oct 26.

15.

Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.

Pathi SS, Lei P, Sreevalsan S, Chadalapaka G, Jutooru I, Safe S.

Nutr Cancer. 2011;63(7):1133-42. doi: 10.1080/01635581.2011.605984. Epub 2011 Sep 15.

16.

GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway.

Pathi SS, Jutooru I, Chadalapaka G, Sreevalsan S, Anand S, Thatcher GR, Safe S.

Mol Cancer Res. 2011 Feb;9(2):195-202. doi: 10.1158/1541-7786.MCR-10-0363. Epub 2010 Dec 14.

17.

The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis.

Noratto GD, Jutooru I, Safe S, Angel-Morales G, Mertens-Talcott SU.

Mol Nutr Food Res. 2013 Sep;57(9):1638-48. doi: 10.1002/mnfr.201200609. Epub 2013 Mar 8.

PMID:
23471840
18.

Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.

Liu X, Jutooru I, Lei P, Kim K, Lee SO, Brents LK, Prather PL, Safe S.

Mol Cancer Ther. 2012 Jul;11(7):1421-31. doi: 10.1158/1535-7163.MCT-12-0026. Epub 2012 May 2.

19.
20.

Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.

Chintharlapalli S, Papineni S, Ramaiah SK, Safe S.

Cancer Res. 2007 Mar 15;67(6):2816-23.

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