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Evaluation of a rapamycin-regulated serotype 2 adeno-associated viral vector in macaque parotid glands.

Zheng C, Voutetakis A, Metzger M, Afione S, Cotrim AP, Eckhaus MA, Rivera VM, Clackson T, Chiorini JA, Donahue RE, Dunbar CE, Baum BJ.

Oral Dis. 2010 Apr;16(3):269-77. doi: 10.1111/j.1601-0825.2009.01631.x.


AAV5-mediated gene transfer to the parotid glands of non-human primates.

Voutetakis A, Zheng C, Cotrim AP, Mineshiba F, Afione S, Roescher N, Swaim WD, Metzger M, Eckhaus MA, Donahue RE, Dunbar CE, Chiorini JA, Baum BJ.

Gene Ther. 2010 Jan;17(1):50-60. doi: 10.1038/gt.2009.123.


Rapamycin control of transgene expression from a single AAV vector in mouse salivary glands.

Wang J, Voutetakis A, Papa M, Rivera VM, Clackson T, Lodde BM, Mineshiba F, Baum BJ.

Gene Ther. 2006 Jan;13(2):187-90.


Adeno-associated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates.

Voutetakis A, Zheng C, Mineshiba F, Cotrim AP, Goldsmith CM, Schmidt M, Afione S, Roescher N, Metzger M, Eckhaus MA, Chiorini JA, Dunbar CE, Donahue RE, Baum BJ.

Hum Gene Ther. 2007 Feb;18(2):142-50.


Long-term transduction of miniature pig parotid glands using serotype 2 adeno-associated viral vectors.

Hai B, Yan X, Voutetakis A, Zheng C, Cotrim AP, Shan Z, Ding G, Zhang C, Xu J, Goldsmith CM, Afione S, Chiorini JA, Baum BJ, Wang S.

J Gene Med. 2009 Jun;11(6):506-14. doi: 10.1002/jgm.1319.


Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands.

Zheng C, Voutetakis A, Goldstein B, Afione S, Rivera VM, Clackson T, Wenk ML, Boyle M, Nyska A, Chiorini JA, Vallant M, Irwin RD, Baum BJ.

Toxicol Sci. 2011 Sep;123(1):247-55. doi: 10.1093/toxsci/kfr144.


Convenient and reproducible in vivo gene transfer to mouse parotid glands.

Zheng C, Shinomiya T, Goldsmith CM, Di Pasquale G, Baum BJ.

Oral Dis. 2011 Jan;17(1):77-82. doi: 10.1111/j.1601-0825.2010.01707.x.


Salivary glands as a potential gene transfer target for gene therapeutics of some monogenetic endocrine disorders.

Voutetakis A, Bossis I, Kok MR, Zhang W, Wang J, Cotrim AP, Zheng C, Chiorini JA, Nieman LK, Baum BJ.

J Endocrinol. 2005 Jun;185(3):363-72.


Sorting of transgenic secretory proteins in rhesus macaque parotid glands after adenovirus-mediated gene transfer.

Voutetakis A, Zheng C, Metzger M, Cotrim AP, Donahue RE, Dunbar CE, Baum BJ.

Hum Gene Ther. 2008 Dec;19(12):1401-5. doi: 10.1089/hgt.2008.034.


Sorting of transgenic secretory proteins in miniature pig parotid glands following adenoviral-mediated gene transfer.

Yan X, Voutetakis A, Zheng C, Hai B, Zhang C, Baum BJ, Wang S.

J Gene Med. 2007 Sep;9(9):779-87. Erratum in: J Gene Med. 2007 Dec;9(12):1106.


Developing a convenient large animal model for gene transfer to salivary glands in vivo.

Li J, Zheng C, Zhang X, Liu X, Zhang C, Goldsmith CM, Baum BJ, Wang S.

J Gene Med. 2004 Jan;6(1):55-63.


Gender differences in serotype 2 adeno-associated virus biodistribution after administration to rodent salivary glands.

Voutetakis A, Zheng C, Wang J, Goldsmith CM, Afione S, Chiorini JA, Wenk ML, Vallant M, Irwin RD, Baum BJ.

Hum Gene Ther. 2007 Nov;18(11):1109-18.


Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer.

Rivera VM, Gao GP, Grant RL, Schnell MA, Zoltick PW, Rozamus LW, Clackson T, Wilson JM.

Blood. 2005 Feb 15;105(4):1424-30.


Toxicity and biodistribution of the serotype 2 recombinant adeno-associated viral vector, encoding Aquaporin-1, after retroductal delivery to a single mouse parotid gland.

Momot D, Zheng C, Yin H, Elbekai RH, Vallant M, Chiorini JA.

PLoS One. 2014 Mar 25;9(3):e92832. doi: 10.1371/journal.pone.0092832.


Rapamycin control of exocrine protein levels in saliva after adenoviral vector-mediated gene transfer.

Wang J, Voutetakis A, Zheng C, Baum BJ.

Gene Ther. 2004 Apr;11(8):729-33.


Human parathyroid hormone is secreted primarily into the bloodstream after rat parotid gland gene transfer.

Adriaansen J, Perez P, Zheng C, Collins MT, Baum BJ.

Hum Gene Ther. 2011 Jan;22(1):84-92. doi: 10.1089/hum.2010.097.


Rapamycin-regulated control of antiangiogenic tumor therapy following rAAV-mediated gene transfer.

Nguyen M, Huan-Tu G, Gonzalez-Edick M, Rivera VM, Clackson T, Jooss KU, Harding TC.

Mol Ther. 2007 May;15(5):912-20.


A novel hybrid adenoretroviral vector with more extensive E3 deletion extends transgene expression in submandibular glands.

Zheng C, Cotrim AP, Nikolov N, Mineshiba F, Swaim W, Baum BJ.

Hum Gene Ther Methods. 2012 Jun;23(3):169-81. doi: 10.1089/hgtb.2011.175.


AAV2-mediated transfer of the human aquaporin-1 cDNA restores fluid secretion from irradiated miniature pig parotid glands.

Gao R, Yan X, Zheng C, Goldsmith CM, Afione S, Hai B, Xu J, Zhou J, Zhang C, Chiorini JA, Baum BJ, Wang S.

Gene Ther. 2011 Jan;18(1):38-42. doi: 10.1038/gt.2010.128.


Long-term regulated expression of growth hormone in mice after intramuscular gene transfer.

Rivera VM, Ye X, Courage NL, Sachar J, Cerasoli F Jr, Wilson JM, Gilman M.

Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8657-62.

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