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Items: 1 to 20 of 112


Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss.

Thorel F, Népote V, Avril I, Kohno K, Desgraz R, Chera S, Herrera PL.

Nature. 2010 Apr 22;464(7292):1149-54. doi: 10.1038/nature08894. Epub 2010 Apr 4.


Diabetes forum: Extreme makeover of pancreatic alpha-cells.

Zaret KS, White MF.

Nature. 2010 Apr 22;464(7292):1132-3. doi: 10.1038/4641132a. No abstract available.


Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice.

Thorel F, Damond N, Chera S, Wiederkehr A, Thorens B, Meda P, Wollheim CB, Herrera PL.

Diabetes. 2011 Nov;60(11):2872-82. doi: 10.2337/db11-0876. Epub 2011 Sep 16.


Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.

Chera S, Baronnier D, Ghila L, Cigliola V, Jensen JN, Gu G, Furuyama K, Thorel F, Gribble FM, Reimann F, Herrera PL.

Nature. 2014 Oct 23;514(7523):503-7. doi: 10.1038/nature13633. Epub 2014 Aug 20.


Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis.

Ye L, Robertson MA, Hesselson D, Stainier DY, Anderson RM.

Development. 2015 Apr 15;142(8):1407-17. doi: 10.1242/dev.117911.


Conversion of mature human β-cells into glucagon-producing α-cells.

Spijker HS, Ravelli RB, Mommaas-Kienhuis AM, van Apeldoorn AA, Engelse MA, Zaldumbide A, Bonner-Weir S, Rabelink TJ, Hoeben RC, Clevers H, Mummery CL, Carlotti F, de Koning EJ.

Diabetes. 2013 Jul;62(7):2471-80. doi: 10.2337/db12-1001. Epub 2013 Apr 8.


Regeneration of pancreatic non-β endocrine cells in adult mice following a single diabetes-inducing dose of streptozotocin.

Zhang Y, Zhang Y, Bone RN, Cui W, Peng JB, Siegal GP, Wang H, Wu H.

PLoS One. 2012;7(5):e36675. doi: 10.1371/journal.pone.0036675. Epub 2012 May 7.


Activin Enhances α- to β-Cell Transdifferentiation as a Source For β-Cells In Male FSTL3 Knockout Mice.

Brown ML, Andrzejewski D, Burnside A, Schneyer AL.

Endocrinology. 2016 Mar;157(3):1043-54. doi: 10.1210/en.2015-1793. Epub 2016 Jan 4.


Differentially Expressed MicroRNA-483 Confers Distinct Functions in Pancreatic β- and α-Cells.

Mohan R, Mao Y, Zhang S, Zhang YW, Xu CR, Gradwohl G, Tang X.

J Biol Chem. 2015 Aug 7;290(32):19955-66. doi: 10.1074/jbc.M115.650705. Epub 2015 Jun 24.


Beta cell regeneration in human pancreas.

Gianani R.

Semin Immunopathol. 2011 Jan;33(1):23-7. doi: 10.1007/s00281-010-0235-7. Epub 2010 Dec 25. Review.


The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells.

Courtney M, Gjernes E, Druelle N, Ravaud C, Vieira A, Ben-Othman N, Pfeifer A, Avolio F, Leuckx G, Lacas-Gervais S, Burel-Vandenbos F, Ambrosetti D, Hecksher-Sorensen J, Ravassard P, Heimberg H, Mansouri A, Collombat P.

PLoS Genet. 2013 Oct;9(10):e1003934. doi: 10.1371/journal.pgen.1003934. Epub 2013 Oct 31.


The role of glucagon- and somatostatin-secreting cells in the regulation of insulin release and beta-cell function in heterotypic pseudoislets.

Kelly C, Parke HG, McCluskey JT, Flatt PR, McClenaghan NH.

Diabetes Metab Res Rev. 2010 Oct;26(7):525-33. doi: 10.1002/dmrr.1111.


Evolving function and potential of pancreatic alpha cells.

Stanojevic V, Habener JF.

Best Pract Res Clin Endocrinol Metab. 2015 Dec;29(6):859-71. doi: 10.1016/j.beem.2015.10.002. Epub 2015 Oct 8. Review.


α-cell role in β-cell generation and regeneration.

Habener JF, Stanojevic V.

Islets. 2012 May-Jun;4(3):188-98. doi: 10.4161/isl.20500. Review.


[Conversion of adult pancreatic alpha-cells to beta-cells in diabetic mice].

Thorel F, Herrera PL.

Med Sci (Paris). 2010 Nov;26(11):906-9. doi: 10.1051/medsci/20102611906. French. No abstract available.


Pancreatic α-cell specific deletion of mouse Arx leads to α-cell identity loss.

Wilcox CL, Terry NA, Walp ER, Lee RA, May CL.

PLoS One. 2013 Jun 13;8(6):e66214. doi: 10.1371/journal.pone.0066214. Print 2013.


Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.

Yang YP, Thorel F, Boyer DF, Herrera PL, Wright CV.

Genes Dev. 2011 Aug 15;25(16):1680-5. doi: 10.1101/gad.16875711.


Pancreatic β-cell neogenesis by direct conversion from mature α-cells.

Chung CH, Hao E, Piran R, Keinan E, Levine F.

Stem Cells. 2010 Sep;28(9):1630-8. doi: 10.1002/stem.482.


A new paradigm in cell therapy for diabetes: turning pancreatic α-cells into β-cells.

Sangan CB, Tosh D.

Bioessays. 2010 Oct;32(10):881-4. doi: 10.1002/bies.201000074. Epub 2010 Aug 27.


How to make a functional β-cell.

Pagliuca FW, Melton DA.

Development. 2013 Jun;140(12):2472-83. doi: 10.1242/dev.093187. Review.

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