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Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells.

Jan YH, Heck DE, Gray JP, Zheng H, Casillas RP, Laskin DL, Laskin JD.

Chem Res Toxicol. 2010 Jun 21;23(6):1045-53. doi: 10.1021/tx100040k.


Acetaminophen reactive intermediates target hepatic thioredoxin reductase.

Jan YH, Heck DE, Dragomir AC, Gardner CR, Laskin DL, Laskin JD.

Chem Res Toxicol. 2014 May 19;27(5):882-94. doi: 10.1021/tx5000443. Epub 2014 Apr 4.


Thioredoxin Cross-Linking by Nitrogen Mustard in Lung Epithelial Cells: Formation of Multimeric Thioredoxin/Thioredoxin Reductase Complexes and Inhibition of Disulfide Reduction.

Jan YH, Heck DE, Casillas RP, Laskin DL, Laskin JD.

Chem Res Toxicol. 2015 Nov 16;28(11):2091-103. doi: 10.1021/acs.chemrestox.5b00194. Epub 2015 Oct 19.


Inhibition of NADPH cytochrome P450 reductase by the model sulfur mustard vesicant 2-chloroethyl ethyl sulfide is associated with increased production of reactive oxygen species.

Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD.

Toxicol Appl Pharmacol. 2010 Sep 1;247(2):76-82. doi: 10.1016/j.taap.2010.05.015. Epub 2010 Jun 2.


Selective metabolism of hypothiocyanous acid by mammalian thioredoxin reductase promotes lung innate immunity and antioxidant defense.

Chandler JD, Nichols DP, Nick JA, Hondal RJ, Day BJ.

J Biol Chem. 2013 Jun 21;288(25):18421-8. doi: 10.1074/jbc.M113.468090. Epub 2013 Apr 29.


Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase.

Hashemy SI, Ungerstedt JS, Zahedi Avval F, Holmgren A.

J Biol Chem. 2006 Apr 21;281(16):10691-7. Epub 2006 Feb 14.


The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells.

Myers CR, Myers JM.

Toxicology. 2009 Mar 4;257(1-2):95-104. doi: 10.1016/j.tox.2008.12.013. Epub 2008 Dec 24.


Inhibition of thioredoxin and thioredoxin reductase by 4-hydroxy-2-nonenal in vitro and in vivo.

Fang J, Holmgren A.

J Am Chem Soc. 2006 Feb 15;128(6):1879-85.


Molecular bases of thioredoxin and thioredoxin reductase-mediated prooxidant actions of (-)-epigallocatechin-3-gallate.

Zhang H, Cao D, Cui W, Ji M, Qian X, Zhong L.

Free Radic Biol Med. 2010 Dec 15;49(12):2010-8. doi: 10.1016/j.freeradbiomed.2010.09.031. Epub 2010 Oct 14.


Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.

Sunil VR, Patel-Vayas K, Shen J, Gow AJ, Laskin JD, Laskin DL.

Toxicol Appl Pharmacol. 2011 Feb 1;250(3):245-55. doi: 10.1016/j.taap.2010.10.027. Epub 2010 Nov 9.


A mechanistic investigation of the C-terminal redox motif of thioredoxin reductase from Plasmodium falciparum.

Snider GW, Dustin CM, Ruggles EL, Hondal RJ.

Biochemistry. 2014 Jan 28;53(3):601-9. doi: 10.1021/bi400931k. Epub 2014 Jan 17.


Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning.

Carvalho CM, Lu J, Zhang X, Arnér ES, Holmgren A.

FASEB J. 2011 Jan;25(1):370-81. doi: 10.1096/fj.10-157594. Epub 2010 Sep 1.


Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302.

Li S, Zhang J, Li J, Chen D, Matteucci M, Curd J, Duan JX.

Biol Trace Elem Res. 2010 Sep;136(3):294-301. doi: 10.1007/s12011-009-8544-1. Epub 2009 Oct 17.


Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells.

Cenas N, Prast S, Nivinskas H, Sarlauskas J, Arnér ES.

J Biol Chem. 2006 Mar 3;281(9):5593-603. Epub 2005 Dec 14.

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