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Items: 1 to 20 of 178

1.

Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome.

Jang H, Arce FT, Ramachandran S, Capone R, Azimova R, Kagan BL, Nussinov R, Lal R.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6538-43. doi: 10.1073/pnas.0914251107. Epub 2010 Mar 22.

2.

Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology.

Connelly L, Jang H, Arce FT, Capone R, Kotler SA, Ramachandran S, Kagan BL, Nussinov R, Lal R.

J Phys Chem B. 2012 Feb 9;116(5):1728-35. doi: 10.1021/jp2108126. Epub 2012 Jan 25.

3.

Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: atomic force microscopy and molecular dynamics simulations.

Connelly L, Jang H, Arce FT, Ramachandran S, Kagan BL, Nussinov R, Lal R.

Biochemistry. 2012 Apr 10;51(14):3031-8. doi: 10.1021/bi300257e. Epub 2012 Mar 28.

PMID:
22413858
4.

Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm.

Lal R, Lin H, Quist AP.

Biochim Biophys Acta. 2007 Aug;1768(8):1966-75. Epub 2007 May 3. Review.

5.

The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid.

Lalowski M, Golabek A, Lemere CA, Selkoe DJ, Wisniewski HM, Beavis RC, Frangione B, Wisniewski T.

J Biol Chem. 1996 Dec 27;271(52):33623-31.

6.

Alzheimer's disease.

De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV.

Subcell Biochem. 2012;65:329-52. doi: 10.1007/978-94-007-5416-4_14. Review.

PMID:
23225010
7.

Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology.

Lin H, Bhatia R, Lal R.

FASEB J. 2001 Nov;15(13):2433-44. Erratum in: FASEB J 2002 May;16(7):759.

PMID:
11689468
8.

Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome.

Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, Ericsson M, Soscia SJ, Mocofanescu A, Folkerth RD, Robb RM, Kuszak JR, Clark JI, Tanzi RE, Hunter DG, Goldstein LE.

PLoS One. 2010 May 20;5(5):e10659. doi: 10.1371/journal.pone.0010659.

9.

The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?

Dinamarca MC, Weinstein D, Monasterio O, Inestrosa NC.

Biochemistry. 2011 Sep 27;50(38):8127-37. doi: 10.1021/bi201246t. Epub 2011 Sep 1.

PMID:
21838267
10.

Ion Channel Formation by Amyloid-β42 Oligomers but Not Amyloid-β40 in Cellular Membranes.

Bode DC, Baker MD, Viles JH.

J Biol Chem. 2017 Jan 27;292(4):1404-1413. doi: 10.1074/jbc.M116.762526. Epub 2016 Dec 7.

PMID:
27927987
12.

Effects of amyloid-β peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels.

Kim S, Rhim H.

Mol Cells. 2011 Sep;32(3):289-94. doi: 10.1007/s10059-011-0075-x. Epub 2011 Aug 4.

13.
14.

K3 fragment of amyloidogenic beta(2)-microglobulin forms ion channels: implication for dialysis related amyloidosis.

Mustata M, Capone R, Jang H, Arce FT, Ramachandran S, Lal R, Nussinov R.

J Am Chem Soc. 2009 Oct 21;131(41):14938-45. doi: 10.1021/ja9049299.

15.

Mechanism of cholesterol-assisted oligomeric channel formation by a short Alzheimer β-amyloid peptide.

Di Scala C, Troadec JD, Lelièvre C, Garmy N, Fantini J, Chahinian H.

J Neurochem. 2014 Jan;128(1):186-95. doi: 10.1111/jnc.12390. Epub 2013 Aug 28.

16.

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases.

Wirths O, Bethge T, Marcello A, Harmeier A, Jawhar S, Lucassen PJ, Multhaup G, Brody DL, Esparza T, Ingelsson M, Kalimo H, Lannfelt L, Bayer TA.

J Neural Transm (Vienna). 2010 Jan;117(1):85-96. doi: 10.1007/s00702-009-0314-x. Epub 2009 Oct 13.

17.

Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures.

Ferreira IL, Bajouco LM, Mota SI, Auberson YP, Oliveira CR, Rego AC.

Cell Calcium. 2012 Feb;51(2):95-106. doi: 10.1016/j.ceca.2011.11.008. Epub 2011 Dec 15.

PMID:
22177709
18.
19.

In vivo SPECT imaging of amyloid-β deposition with radioiodinated imidazo[1,2-a]pyridine derivative DRM106 in a mouse model of Alzheimer's disease.

Chen CJ, Bando K, Ashino H, Taguchi K, Shiraishi H, Shima K, Fujimoto O, Kitamura C, Matsushima S, Uchida K, Nakahara Y, Kasahara H, Minamizawa T, Jiang C, Zhang MR, Ono M, Tokunaga M, Suhara T, Higuchi M, Yamada K, Ji B.

J Nucl Med. 2015 Jan;56(1):120-6. doi: 10.2967/jnumed.114.146944. Epub 2014 Dec 4.

20.

Amino-terminal modification and tyrosine phosphorylation of [corrected] carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain.

Russo C, Salis S, Dolcini V, Venezia V, Song XH, Teller JK, Schettini G.

Neurobiol Dis. 2001 Feb;8(1):173-80. Erratum in: Neurobiol Dis 2001 Jun;8(3):540.

PMID:
11162251

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