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Items: 1 to 20 of 85

1.

Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen.

Steinbrecher KA, Horowitz NA, Blevins EA, Barney KA, Shaw MA, Harmel-Laws E, Finkelman FD, Flick MJ, Pinkerton MD, Talmage KE, Kombrinck KW, Witte DP, Palumbo JS.

Cancer Res. 2010 Apr 1;70(7):2634-43. doi: 10.1158/0008-5472.CAN-09-3465. Epub 2010 Mar 16.

2.

Fibrin(ogen)-alpha M beta 2 interactions regulate leukocyte function and innate immunity in vivo.

Flick MJ, Du X, Degen JL.

Exp Biol Med (Maywood). 2004 Dec;229(11):1105-10. Review.

PMID:
15564436
3.

Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo.

Flick MJ, Du X, Witte DP, Jirousková M, Soloviev DA, Busuttil SJ, Plow EF, Degen JL.

J Clin Invest. 2004 Jun;113(11):1596-606.

4.

Thrombin drives tumorigenesis in colitis-associated colon cancer.

Turpin B, Miller W, Rosenfeldt L, Kombrinck K, Flick MJ, Steinbrecher KA, Harmel-Laws E, Mullins ES, Shaw M, Witte DP, Revenko A, Monia B, Palumbo JS.

Cancer Res. 2014 Jun 1;74(11):3020-3030. doi: 10.1158/0008-5472.CAN-13-3276. Epub 2014 Apr 7.

5.

Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif.

Flick MJ, LaJeunesse CM, Talmage KE, Witte DP, Palumbo JS, Pinkerton MD, Thornton S, Degen JL.

J Clin Invest. 2007 Nov;117(11):3224-35.

6.

Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice.

Zhao J, Bulek K, Gulen MF, Zepp JA, Karagkounis G, Martin BN, Zhou H, Yu M, Liu X, Huang E, Fox PL, Kalady MF, Markowitz SD, Li X.

Gastroenterology. 2015 Dec;149(7):1860-1871.e8. doi: 10.1053/j.gastro.2015.08.051. Epub 2015 Sep 5.

7.

Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of Mmp12.

Kopec AK, Joshi N, Cline-Fedewa H, Wojcicki AV, Ray JL, Sullivan BP, Froehlich JE, Johnson BF, Flick MJ, Luyendyk JP.

J Hepatol. 2017 Apr;66(4):787-797. doi: 10.1016/j.jhep.2016.12.004. Epub 2016 Dec 10.

PMID:
27965156
8.

Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor.

Vidal B, Ardite E, Suelves M, Ruiz-Bonilla V, Janué A, Flick MJ, Degen JL, Serrano AL, Muñoz-Cánoves P.

Hum Mol Genet. 2012 May 1;21(9):1989-2004. doi: 10.1093/hmg/dds012. Epub 2012 Mar 1.

9.

NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice.

Burkitt MD, Hanedi AF, Duckworth CA, Williams JM, Tang JM, O'Reilly LA, Putoczki TL, Gerondakis S, Dimaline R, Caamano JH, Pritchard DM.

J Pathol. 2015 Jul;236(3):326-36. doi: 10.1002/path.4527. Epub 2015 Apr 21.

10.

Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.

Pouyet L, Roisin-Bouffay C, Clément A, Millet V, Garcia S, Chasson L, Issaly N, Rostan A, Hofman P, Naquet P, Galland F.

Inflamm Bowel Dis. 2010 Jan;16(1):96-104. doi: 10.1002/ibd.21031.

PMID:
19572375
11.

A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate.

Tanaka T, Kohno H, Suzuki R, Yamada Y, Sugie S, Mori H.

Cancer Sci. 2003 Nov;94(11):965-73.

12.

Effect of genetic deletion or pharmacological antagonism of tumor necrosis factor alpha on colitis-associated carcinogenesis in mice.

Craven B, Zaric V, Martin A, Mureau C, Egan LJ.

Inflamm Bowel Dis. 2015 Mar;21(3):485-95. doi: 10.1097/MIB.0000000000000303.

PMID:
25581824
13.

The neurotensin receptor-1 promotes tumor development in a sporadic but not an inflammation-associated mouse model of colon cancer.

Bugni JM, Rabadi LA, Jubbal K, Karagiannides I, Lawson G, Pothoulakis C.

Int J Cancer. 2012 Apr 15;130(8):1798-805. doi: 10.1002/ijc.26208. Epub 2011 Nov 17.

14.

Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism.

Joshi N, Kopec AK, Ray JL, Cline-Fedewa H, Nawabi A, Schmitt T, Nault R, Zacharewski TR, Rockwell CE, Flick MJ, Luyendyk JP.

Blood. 2016 Jun 2;127(22):2751-62. doi: 10.1182/blood-2015-09-670703. Epub 2016 Feb 26.

15.

Deletion of p38-alpha mitogen-activated protein kinase within the intestinal epithelium promotes colon tumorigenesis.

Wakeman D, Schneider JE, Liu J, Wandu WS, Erwin CR, Guo J, Stappenbeck TS, Warner BW.

Surgery. 2012 Aug;152(2):286-93. doi: 10.1016/j.surg.2012.05.009.

16.

Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia.

Flick MJ, Du X, Prasad JM, Raghu H, Palumbo JS, Smeds E, Höök M, Degen JL.

Blood. 2013 Mar 7;121(10):1783-94. doi: 10.1182/blood-2012-09-453894. Epub 2013 Jan 8.

17.
19.

Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis.

Asfaha S, Dubeykovskiy AN, Tomita H, Yang X, Stokes S, Shibata W, Friedman RA, Ariyama H, Dubeykovskaya ZA, Muthupalani S, Ericksen R, Frucht H, Fox JG, Wang TC.

Gastroenterology. 2013 Jan;144(1):155-66. doi: 10.1053/j.gastro.2012.09.057. Epub 2012 Oct 3.

20.

Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancer.

Waldner MJ, Wirtz S, Becker C, Seidel D, Tubbe I, Cappel K, Hähnel PS, Galle PR, Schuler M, Neurath MF.

Inflamm Bowel Dis. 2010 Apr;16(4):559-67. doi: 10.1002/ibd.21107.

PMID:
19785028

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