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Items: 1 to 20 of 133

1.

TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways.

Gunnell LM, Jonason JH, Loiselle AE, Kohn A, Schwarz EM, Hilton MJ, O'Keefe RJ.

J Bone Miner Res. 2010 Aug;25(8):1784-97. doi: 10.1002/jbmr.79.

2.

TAK1 mediates BMP signaling in cartilage.

Greenblatt MB, Shim JH, Glimcher LH.

Ann N Y Acad Sci. 2010 Mar;1192:385-90. doi: 10.1111/j.1749-6632.2009.05222.x.

3.

TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages.

Gao L, Sheu TJ, Dong Y, Hoak DM, Zuscik MJ, Schwarz EM, Hilton MJ, O'Keefe RJ, Jonason JH.

J Cell Sci. 2013 Dec 15;126(Pt 24):5704-13. doi: 10.1242/jcs.135483. Epub 2013 Oct 21.

4.

TGF-β-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells.

Yumoto K, Thomas PS, Lane J, Matsuzaki K, Inagaki M, Ninomiya-Tsuji J, Scott GJ, Ray MK, Ishii M, Maxson R, Mishina Y, Kaartinen V.

J Biol Chem. 2013 May 10;288(19):13467-80. doi: 10.1074/jbc.M112.431775. Epub 2013 Apr 1.

5.

TAK1 is an essential regulator of BMP signalling in cartilage.

Shim JH, Greenblatt MB, Xie M, Schneider MD, Zou W, Zhai B, Gygi S, Glimcher LH.

EMBO J. 2009 Jul 22;28(14):2028-41. doi: 10.1038/emboj.2009.162. Epub 2009 Jun 18.

6.

Transforming growth factor-beta-activated kinase-1 (TAK1), a MAP3K, interacts with Smad proteins and interferes with osteogenesis in murine mesenchymal progenitors.

Hoffmann A, Preobrazhenska O, Wodarczyk C, Medler Y, Winkel A, Shahab S, Huylebroeck D, Gross G, Verschueren K.

J Biol Chem. 2005 Jul 22;280(29):27271-83. Epub 2005 May 23.

7.

Immunolocalization of TAK1, TAB1, and p38 in the developing rat molar.

Moriguchi M, Yamada M, Miake Y, Yanagisawa T.

Anat Sci Int. 2011 Jun;86(2):69-77. doi: 10.1007/s12565-010-0089-z. Epub 2010 Aug 21.

PMID:
20730577
8.

ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development.

Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ.

J Bone Miner Res. 2003 Sep;18(9):1593-604.

9.

Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development.

Kohn A, Dong Y, Mirando AJ, Jesse AM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Development. 2012 Mar;139(6):1198-212. doi: 10.1242/dev.070649.

10.

Smad7 Inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways.

Iwai T, Murai J, Yoshikawa H, Tsumaki N.

J Biol Chem. 2008 Oct 3;283(40):27154-64. doi: 10.1074/jbc.M801175200. Epub 2008 Jul 21.

11.

Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development.

Song Z, Liu C, Iwata J, Gu S, Suzuki A, Sun C, He W, Shu R, Li L, Chai Y, Chen Y.

J Biol Chem. 2013 Apr 12;288(15):10440-50. doi: 10.1074/jbc.M112.432286. Epub 2013 Mar 4.

12.

TGF-β1-activated kinase-1 regulates inflammation and fibrosis in the obstructed kidney.

Ma FY, Tesch GH, Ozols E, Xie M, Schneider MD, Nikolic-Paterson DJ.

Am J Physiol Renal Physiol. 2011 Jun;300(6):F1410-21. doi: 10.1152/ajprenal.00018.2011. Epub 2011 Mar 2.

13.

Inhibition of BMP and of TGFβ receptors downregulates expression of XIAP and TAK1 leading to lung cancer cell death.

Augeri DJ, Langenfeld E, Castle M, Gilleran JA, Langenfeld J.

Mol Cancer. 2016 Apr 6;15:27. doi: 10.1186/s12943-016-0511-9.

14.

CCN6 modulates BMP signaling via the Smad-independent TAK1/p38 pathway, acting to suppress metastasis of breast cancer.

Pal A, Huang W, Li X, Toy KA, Nikolovska-Coleska Z, Kleer CG.

Cancer Res. 2012 Sep 15;72(18):4818-28. doi: 10.1158/0008-5472.CAN-12-0154. Epub 2012 Jul 17.

15.

BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6.

Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T.

J Biol Chem. 2000 Jun 9;275(23):17647-52.

16.
17.

Expression of TAK1, a mediator of TGF-beta and BMP signaling, during mouse embryonic development.

Jadrich JL, O'Connor MB, Coucouvanis E.

Gene Expr Patterns. 2003 May;3(2):131-4.

PMID:
12711537
18.

SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling.

Kato K, Bhattaram P, Penzo-Méndez A, Gadi A, Lefebvre V.

J Bone Miner Res. 2015 Sep;30(9):1560-71. doi: 10.1002/jbmr.2504. Epub 2015 May 21.

19.

Activation of the bone morphogenetic protein receptor by H11kinase/Hsp22 promotes cardiac cell growth and survival.

Sui X, Li D, Qiu H, Gaussin V, Depre C.

Circ Res. 2009 Apr 10;104(7):887-95. doi: 10.1161/CIRCRESAHA.108.192328. Epub 2009 Feb 26.

20.

Interaction of TGFβ and BMP signaling pathways during chondrogenesis.

Keller B, Yang T, Chen Y, Munivez E, Bertin T, Zabel B, Lee B.

PLoS One. 2011 Jan 28;6(1):e16421. doi: 10.1371/journal.pone.0016421.

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