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The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.

Soscia SJ, Kirby JE, Washicosky KJ, Tucker SM, Ingelsson M, Hyman B, Burton MA, Goldstein LE, Duong S, Tanzi RE, Moir RD.

PLoS One. 2010 Mar 3;5(3):e9505. doi: 10.1371/journal.pone.0009505.


The antimicrobial protection hypothesis of Alzheimer's disease.

Moir RD, Lathe R, Tanzi RE.

Alzheimers Dement. 2018 Dec;14(12):1602-1614. doi: 10.1016/j.jalz.2018.06.3040. Epub 2018 Oct 9.


Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease.

Kumar DK, Choi SH, Washicosky KJ, Eimer WA, Tucker S, Ghofrani J, Lefkowitz A, McColl G, Goldstein LE, Tanzi RE, Moir RD.

Sci Transl Med. 2016 May 25;8(340):340ra72. doi: 10.1126/scitranslmed.aaf1059.


Alzheimer's disease.

De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV.

Subcell Biochem. 2012;65:329-52. doi: 10.1007/978-94-007-5416-4_14. Review.


Anti-Viral Properties of Amyloid-β Peptides.

Bourgade K, Dupuis G, Frost EH, Fülöp T.

J Alzheimers Dis. 2016 Oct 4;54(3):859-878. Review.


The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer's disease.

Brock AJ, Kasus-Jacobi A, Lerner M, Logan S, Adesina AM, Anne Pereira H.

Histochem Cell Biol. 2015 Oct;144(4):293-308. doi: 10.1007/s00418-015-1347-x. Epub 2015 Jul 14.


Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients.

Li R, Lindholm K, Yang LB, Yue X, Citron M, Yan R, Beach T, Sue L, Sabbagh M, Cai H, Wong P, Price D, Shen Y.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3632-7. Epub 2004 Feb 20.


Pyroglutamate-modified amyloid-β protein demonstrates similar properties in an Alzheimer's disease familial mutant knock-in mouse and Alzheimer's disease brain.

Wu G, Miller RA, Connolly B, Marcus J, Renger J, Savage MJ.

Neurodegener Dis. 2014;14(2):53-66. doi: 10.1159/000353634. Epub 2013 Oct 23.


Amyloid-β peptide-induced extracellular S100A9 depletion is associated with decrease of antimicrobial peptide activity in human THP-1 monocytes.

Lee EO, Yang JH, Chang KA, Suh YH, Chong YH.

J Neuroinflammation. 2013 May 30;10:68. doi: 10.1186/1742-2094-10-68.


Transthyretin stabilization by iododiflunisal promotes amyloid-β peptide clearance, decreases its deposition, and ameliorates cognitive deficits in an Alzheimer's disease mouse model.

Ribeiro CA, Oliveira SM, Guido LF, Magalhães A, Valencia G, Arsequell G, Saraiva MJ, Cardoso I.

J Alzheimers Dis. 2014;39(2):357-70. doi: 10.3233/JAD-131355.


A shift in microglial β-amyloid binding in Alzheimer's disease is associated with cerebral amyloid angiopathy.

Zabel M, Schrag M, Crofton A, Tung S, Beaufond P, Van Ornam J, Dininni A, Vinters HV, Coppola G, Kirsch WM.

Brain Pathol. 2013 Jul;23(4):390-401. doi: 10.1111/bpa.12005. Epub 2012 Nov 28.


Tissue transglutaminase-catalysed cross-linking induces Apolipoprotein E multimers inhibiting Apolipoprotein E's protective effects towards amyloid-beta-induced toxicity.

de Jager M, Drukarch B, Hofstee M, Brevé J, Jongenelen CA, Bol JG, Wilhelmus MM.

J Neurochem. 2015 Sep;134(6):1116-28. doi: 10.1111/jnc.13203. Epub 2015 Jul 7.


The heterogeneous nature of Cu2+ interactions with Alzheimer's amyloid-β peptide.

Drew SC, Barnham KJ.

Acc Chem Res. 2011 Nov 15;44(11):1146-55. doi: 10.1021/ar200014u. Epub 2011 Jun 29.


Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases.

Wirths O, Bethge T, Marcello A, Harmeier A, Jawhar S, Lucassen PJ, Multhaup G, Brody DL, Esparza T, Ingelsson M, Kalimo H, Lannfelt L, Bayer TA.

J Neural Transm (Vienna). 2010 Jan;117(1):85-96. doi: 10.1007/s00702-009-0314-x. Epub 2009 Oct 13.


Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology.

Zhao Z, Ho L, Wang J, Qin W, Festa ED, Mobbs C, Hof P, Rocher A, Masur S, Haroutunian V, Pasinetti GM.

FASEB J. 2005 Dec;19(14):2081-2. Epub 2005 Sep 26.


MyD88 acts as an adaptor protein for inflammatory signalling induced by amyloid-β in macrophages.

O'Halloran S, O'Leary A, Kuijper T, Downer EJ.

Immunol Lett. 2014 Nov;162(1 Pt A):109-18. doi: 10.1016/j.imlet.2014.08.001. Epub 2014 Aug 12.


Prion protein is decreased in Alzheimer's brain and inversely correlates with BACE1 activity, amyloid-β levels and Braak stage.

Whitehouse IJ, Miners JS, Glennon EB, Kehoe PG, Love S, Kellett KA, Hooper NM.

PLoS One. 2013;8(4):e59554. doi: 10.1371/journal.pone.0059554. Epub 2013 Apr 5.


Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease.

Lue LF, Kuo YM, Roher AE, Brachova L, Shen Y, Sue L, Beach T, Kurth JH, Rydel RE, Rogers J.

Am J Pathol. 1999 Sep;155(3):853-62.


Quantitative proteomics reveals that PEA15 regulates astroglial Aβ phagocytosis in an Alzheimer's disease mouse model.

Lv J, Ma S, Zhang X, Zheng L, Ma Y, Zhao X, Lai W, Shen H, Wang Q, Ji J.

J Proteomics. 2014 Oct 14;110:45-58. doi: 10.1016/j.jprot.2014.07.028. Epub 2014 Aug 7.


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