Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 96

1.

p62, an autophagy hero or culprit?

Rusten TE, Stenmark H.

Nat Cell Biol. 2010 Mar;12(3):207-9. doi: 10.1038/ncb0310-207.

PMID:
20190829
2.

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.

Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M.

Nat Cell Biol. 2010 Mar;12(3):213-23. doi: 10.1038/ncb2021. Epub 2010 Feb 21.

PMID:
20173742
3.

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.

Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M.

Mol Cell. 2013 Sep 12;51(5):618-31. doi: 10.1016/j.molcel.2013.08.003. Epub 2013 Sep 5.

4.

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.

Jain A, Lamark T, Sjøttem E, Larsen KB, Awuh JA, Øvervatn A, McMahon M, Hayes JD, Johansen T.

J Biol Chem. 2010 Jul 16;285(29):22576-91. doi: 10.1074/jbc.M110.118976. Epub 2010 May 7.

5.

Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy.

Ishimura R, Tanaka K, Komatsu M.

FEBS Lett. 2014 Mar 3;588(5):822-8. doi: 10.1016/j.febslet.2014.01.045. Epub 2014 Feb 1.

6.

Keap1 degradation by autophagy for the maintenance of redox homeostasis.

Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, Yamamoto M.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13561-6. doi: 10.1073/pnas.1121572109. Epub 2012 Aug 7.

7.

Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced lipotoxicity.

Park JS, Kang DH, Lee DH, Bae SH.

Biochem Biophys Res Commun. 2015 Oct 9;466(1):131-7. doi: 10.1016/j.bbrc.2015.08.120. Epub 2015 Aug 30.

PMID:
26325428
8.

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor.

Katsuragi Y, Ichimura Y, Komatsu M.

FEBS J. 2015 Dec;282(24):4672-8. doi: 10.1111/febs.13540. Epub 2015 Oct 16. Review.

9.

PF-4708671, a specific inhibitor of p70 ribosomal S6 kinase 1, activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1.

Park JS, Kang DH, Lee DH, Bae SH.

Biochem Biophys Res Commun. 2015 Oct 23;466(3):499-504. doi: 10.1016/j.bbrc.2015.09.059. Epub 2015 Sep 14.

PMID:
26381178
10.

Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation.

Yin S, Cao W.

Mol Cell Biol. 2015 Aug;35(15):2673-83. doi: 10.1128/MCB.00105-15. Epub 2015 May 26.

11.

Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.

Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, Komatsu M.

J Biol Chem. 2014 Sep 5;289(36):24944-55. doi: 10.1074/jbc.M114.580357. Epub 2014 Jul 21.

12.

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.

Inami Y, Waguri S, Sakamoto A, Kouno T, Nakada K, Hino O, Watanabe S, Ando J, Iwadate M, Yamamoto M, Lee MS, Tanaka K, Komatsu M.

J Cell Biol. 2011 Apr 18;193(2):275-84. doi: 10.1083/jcb.201102031. Epub 2011 Apr 11.

13.

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis.

Pan JA, Sun Y, Jiang YP, Bott AJ, Jaber N, Dou Z, Yang B, Chen JS, Catanzaro JM, Du C, Ding WX, Diaz-Meco MT, Moscat J, Ozato K, Lin RZ, Zong WX.

Mol Cell. 2016 Mar 3;61(5):720-733. doi: 10.1016/j.molcel.2016.02.007. Erratum in: Mol Cell. 2016 Apr 7;62(1):149-51.

14.

A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang DD.

Mol Cell Biol. 2010 Jul;30(13):3275-85. doi: 10.1128/MCB.00248-10. Epub 2010 Apr 26.

15.

Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation.

Park JS, Kang DH, Lee DH, Bae SH.

Biochem Biophys Res Commun. 2015 Sep 25;465(3):542-7. doi: 10.1016/j.bbrc.2015.08.056. Epub 2015 Aug 14.

PMID:
26282199
16.

Lipopolysaccharide stimulates p62-dependent autophagy-like aggregate clearance in hepatocytes.

Chen C, Deng M, Sun Q, Loughran P, Billiar TR, Scott MJ.

Biomed Res Int. 2014;2014:267350. doi: 10.1155/2014/267350. Epub 2014 Feb 10.

17.

Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade.

Kwon J, Han E, Bui CB, Shin W, Lee J, Lee S, Choi YB, Lee AH, Lee KH, Park C, Obin MS, Park SK, Seo YJ, Oh GT, Lee HW, Shin J.

EMBO Rep. 2012 Feb 1;13(2):150-6. doi: 10.1038/embor.2011.246.

18.

Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.

Bae SH, Sung SH, Oh SY, Lim JM, Lee SK, Park YN, Lee HE, Kang D, Rhee SG.

Cell Metab. 2013 Jan 8;17(1):73-84. doi: 10.1016/j.cmet.2012.12.002. Epub 2012 Dec 27.

19.

Interaction domains of p62: a bridge between p62 and selective autophagy.

Lin X, Li S, Zhao Y, Ma X, Zhang K, He X, Wang Z.

DNA Cell Biol. 2013 May;32(5):220-7. doi: 10.1089/dna.2012.1915. Epub 2013 Mar 26. Review.

PMID:
23530606
20.

Role of p62/SQSTM1 in liver physiology and pathogenesis.

Manley S, Williams JA, Ding WX.

Exp Biol Med (Maywood). 2013 May;238(5):525-38. doi: 10.1177/1535370213489446. Review.

Supplemental Content

Support Center