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Cholesterol trafficking is required for mTOR activation in endothelial cells.

Xu J, Dang Y, Ren YR, Liu JO.

Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4764-9. doi: 10.1073/pnas.0910872107.


Intestinal cell kinase, a MAP kinase-related kinase, regulates proliferation and G1 cell cycle progression of intestinal epithelial cells.

Fu Z, Kim J, Vidrich A, Sturgill TW, Cohn SM.

Am J Physiol Gastrointest Liver Physiol. 2009 Oct;297(4):G632-40. doi: 10.1152/ajpgi.00066.2009.


Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1.

Du X, Zhang Y, Jo SR, Liu X, Qi Y, Osborne B, Byrne FL, Smith GC, Turner N, Hoehn KL, Brown AJ, Yang H.

Biochem J. 2015 Oct 15;471(2):243-53. doi: 10.1042/BJ20150602.


RAD 001 (everolimus) prevents mTOR and Akt late re-activation in response to imatinib in chronic myeloid leukemia.

Mancini M, Petta S, Martinelli G, Barbieri E, Santucci MA.

J Cell Biochem. 2010 Feb 1;109(2):320-8. doi: 10.1002/jcb.22380.


Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells.

Head SA, Shi W, Zhao L, Gorshkov K, Pasunooti K, Chen Y, Deng Z, Li RJ, Shim JS, Tan W, Hartung T, Zhang J, Zhao Y, Colombini M, Liu JO.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7276-85. doi: 10.1073/pnas.1512867112.


Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells.

Xu Z, Zhang Y, Jiang J, Yang Y, Shi R, Hao B, Zhang Z, Huang Z, Kim JW, Zhang G.

BMC Cancer. 2010 Apr 27;10:161. doi: 10.1186/1471-2407-10-161.


Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition.

Charette N, De Saeger C, Lannoy V, Horsmans Y, Leclercq I, Stärkel P.

Mol Cancer. 2010 Sep 22;9:256. doi: 10.1186/1476-4598-9-256.


mTOR phosphorylated at S2448 binds to raptor and rictor.

Rosner M, Siegel N, Valli A, Fuchs C, Hengstschläger M.

Amino Acids. 2010 Jan;38(1):223-8. doi: 10.1007/s00726-008-0230-7.


G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells.

Gao N, Flynn DC, Zhang Z, Zhong XS, Walker V, Liu KJ, Shi X, Jiang BH.

Am J Physiol Cell Physiol. 2004 Aug;287(2):C281-91.


The PI3K/Akt and mTOR/P70S6K signaling pathways in human uveal melanoma cells: interaction with B-Raf/ERK.

Babchia N, Calipel A, Mouriaux F, Faussat AM, Mascarelli F.

Invest Ophthalmol Vis Sci. 2010 Jan;51(1):421-9. doi: 10.1167/iovs.09-3974.


LY294002 and metformin cooperatively enhance the inhibition of growth and the induction of apoptosis of ovarian cancer cells.

Li C, Liu VW, Chan DW, Yao KM, Ngan HY.

Int J Gynecol Cancer. 2012 Jan;22(1):15-22. doi: 10.1097/IGC.0b013e3182322834.


Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2.

Li W, Petrimpol M, Molle KD, Hall MN, Battegay EJ, Humar R.

Circ Res. 2007 Jan 5;100(1):79-87.


Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression.

Noseda M, Chang L, McLean G, Grim JE, Clurman BE, Smith LL, Karsan A.

Mol Cell Biol. 2004 Oct;24(20):8813-22.


Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma.

Hansel DE, Platt E, Orloff M, Harwalker J, Sethu S, Hicks JL, De Marzo A, Steinle RE, Hsi ED, Theodorescu D, Ching CB, Eng C.

Am J Pathol. 2010 Jun;176(6):3062-72. doi: 10.2353/ajpath.2010.090872.


ERK1/2-dependent activation of mTOR/mTORC1/p70S6K regulates thrombin-induced RPE cell proliferation.

Parrales A, López E, Lee-Rivera I, López-Colomé AM.

Cell Signal. 2013 Apr;25(4):829-38. doi: 10.1016/j.cellsig.2012.12.023.


Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma.

Pene F, Claessens YE, Muller O, Viguié F, Mayeux P, Dreyfus F, Lacombe C, Bouscary D.

Oncogene. 2002 Sep 26;21(43):6587-97.

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