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Items: 1 to 20 of 113

1.

Acetylcholinesterase: from 3D structure to function.

Dvir H, Silman I, Harel M, Rosenberry TL, Sussman JL.

Chem Biol Interact. 2010 Sep 6;187(1-3):10-22. doi: 10.1016/j.cbi.2010.01.042. Epub 2010 Feb 4.

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Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica.

Koellner G, Kryger G, Millard CB, Silman I, Sussman JL, Steiner T.

J Mol Biol. 2000 Feb 18;296(2):713-35.

PMID:
10669619
5.

Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs.

Sussman JL, Harel M, Silman I.

Chem Biol Interact. 1993 Jun;87(1-3):187-97.

PMID:
8343975
6.

Structural insights into substrate traffic and inhibition in acetylcholinesterase.

Colletier JP, Fournier D, Greenblatt HM, Stojan J, Sussman JL, Zaccai G, Silman I, Weik M.

EMBO J. 2006 Jun 21;25(12):2746-56. Epub 2006 Jun 8.

7.

Acetylcholinesterase: how is structure related to function?

Silman I, Sussman JL.

Chem Biol Interact. 2008 Sep 25;175(1-3):3-10. doi: 10.1016/j.cbi.2008.05.035. Epub 2008 Jun 6. Review.

PMID:
18586019
8.

Three-dimensional structure of a complex of E2020 with acetylcholinesterase from Torpedo californica.

Kryger G, Silman I, Sussman JL.

J Physiol Paris. 1998 Jun-Aug;92(3-4):191-4.

PMID:
9789806
10.

A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase.

Silman I, Millard CB, Ordentlich A, Greenblatt HM, Harel M, Barak D, Shafferman A, Sussman JL.

Chem Biol Interact. 1999 May 14;119-120:43-52. Review.

PMID:
10421437
11.

Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group.

Bartolucci C, Stojan J, Yu QS, Greig NH, Lamba D.

Biochem J. 2012 Jun 1;444(2):269-77. doi: 10.1042/BJ20111675.

12.

The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad.

Paz A, Xie Q, Greenblatt HM, Fu W, Tang Y, Silman I, Qiu Z, Sussman JL.

J Med Chem. 2009 Apr 23;52(8):2543-9. doi: 10.1021/jm801657v.

PMID:
19326912
13.

Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase.

Xu Y, Colletier JP, Weik M, Qin G, Jiang H, Silman I, Sussman JL.

Biophys J. 2010 Dec 15;99(12):4003-11. doi: 10.1016/j.bpj.2010.10.047.

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The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase.

Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, Potter PM.

Chem Biol Interact. 2005 Dec 15;157-158:153-7. Epub 2005 Nov 14.

PMID:
16289500
16.

Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives.

Bartolucci C, Haller LA, Jordis U, Fels G, Lamba D.

J Med Chem. 2010 Jan 28;53(2):745-51. doi: 10.1021/jm901296p.

PMID:
20025280
17.

"Back door" opening implied by the crystal structure of a carbamoylated acetylcholinesterase.

Bartolucci C, Perola E, Cellai L, Brufani M, Lamba D.

Biochemistry. 1999 May 4;38(18):5714-9.

PMID:
10231521
18.

Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations.

Sanson B, Colletier JP, Xu Y, Lang PT, Jiang H, Silman I, Sussman JL, Weik M.

Protein Sci. 2011 Jul;20(7):1114-8. doi: 10.1002/pro.661. Epub 2011 Jun 10.

19.

The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.

Greenblatt HM, Guillou C, Guénard D, Argaman A, Botti S, Badet B, Thal C, Silman I, Sussman JL.

J Am Chem Soc. 2004 Dec 1;126(47):15405-11.

PMID:
15563167
20.

A neutral molecule in a cation-binding site: specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica.

Koellner G, Steiner T, Millard CB, Silman I, Sussman JL.

J Mol Biol. 2002 Jul 19;320(4):721-5.

PMID:
12095250

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