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Items: 1 to 20 of 121


An aspartyl protease directs malaria effector proteins to the host cell.

Boddey JA, Hodder AN, Günther S, Gilson PR, Patsiouras H, Kapp EA, Pearce JA, de Koning-Ward TF, Simpson RJ, Crabb BS, Cowman AF.

Nature. 2010 Feb 4;463(7281):627-31. doi: 10.1038/nature08728.


Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte.

Russo I, Babbitt S, Muralidharan V, Butler T, Oksman A, Goldberg DE.

Nature. 2010 Feb 4;463(7281):632-6. doi: 10.1038/nature08726.


The C-terminal portion of the cleaved HT motif is necessary and sufficient to mediate export of proteins from the malaria parasite into its host cell.

Tarr SJ, Cryar A, Thalassinos K, Haldar K, Osborne AR.

Mol Microbiol. 2013 Feb;87(4):835-50. doi: 10.1111/mmi.12133. Epub 2013 Jan 21.


Role of plasmepsin V in export of diverse protein families from the Plasmodium falciparum exportome.

Boddey JA, Carvalho TG, Hodder AN, Sargeant TJ, Sleebs BE, Marapana D, Lopaticki S, Nebl T, Cowman AF.

Traffic. 2013 May;14(5):532-50. doi: 10.1111/tra.12053. Epub 2013 Feb 27.


Endoplasmic reticulum PI(3)P lipid binding targets malaria proteins to the host cell.

Bhattacharjee S, Stahelin RV, Speicher KD, Speicher DW, Haldar K.

Cell. 2012 Jan 20;148(1-2):201-12. doi: 10.1016/j.cell.2011.10.051.


Experimental determination of the membrane topology of the Plasmodium protease Plasmepsin V.

Tarr SJ, Osborne AR.

PLoS One. 2015 Apr 7;10(4):e0121786. doi: 10.1371/journal.pone.0121786. eCollection 2015.


Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.

Hodder AN, Sleebs BE, Czabotar PE, Gazdik M, Xu Y, O'Neill MT, Lopaticki S, Nebl T, Triglia T, Smith BJ, Lowes K, Boddey JA, Cowman AF.

Nat Struct Mol Biol. 2015 Aug;22(8):590-6. doi: 10.1038/nsmb.3061. Epub 2015 Jul 27.


Role of the Plasmodium export element in trafficking parasite proteins to the infected erythrocyte.

Boddey JA, Moritz RL, Simpson RJ, Cowman AF.

Traffic. 2009 Mar;10(3):285-99. doi: 10.1111/j.1600-0854.2008.00864.x. Epub 2008 Dec 4.


Plasmodium species: master renovators of their host cells.

de Koning-Ward TF, Dixon MW, Tilley L, Gilson PR.

Nat Rev Microbiol. 2016 Aug;14(8):494-507. doi: 10.1038/nrmicro.2016.79. Epub 2016 Jul 4. Review.


Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites.

Sleebs BE, Lopaticki S, Marapana DS, O'Neill MT, Rajasekaran P, Gazdik M, Günther S, Whitehead LW, Lowes KN, Barfod L, Hviid L, Shaw PJ, Hodder AN, Smith BJ, Cowman AF, Boddey JA.

PLoS Biol. 2014 Jul 1;12(7):e1001897. doi: 10.1371/journal.pbio.1001897. eCollection 2014 Jul.


Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes.

Riglar DT, Rogers KL, Hanssen E, Turnbull L, Bullen HE, Charnaud SC, Przyborski J, Gilson PR, Whitchurch CB, Crabb BS, Baum J, Cowman AF.

Nat Commun. 2013;4:1415. doi: 10.1038/ncomms2449.


New insights into protein export in malaria parasites.

Haase S, de Koning-Ward TF.

Cell Microbiol. 2010 May 1;12(5):580-7. doi: 10.1111/j.1462-5822.2010.01455.x. Epub 2010 Feb 19. Review.


Protein targeting from malaria parasites to host erythrocytes.

Römisch K.

Traffic. 2005 Aug;6(8):706-9. Review.


The host targeting motif in exported Plasmodium proteins is cleaved in the parasite endoplasmic reticulum.

Osborne AR, Speicher KD, Tamez PA, Bhattacharjee S, Speicher DW, Haldar K.

Mol Biochem Parasitol. 2010 May;171(1):25-31. doi: 10.1016/j.molbiopara.2010.01.003. Epub 2010 Feb 1.


Functional evaluation of Plasmodium export signals in Plasmodium berghei suggests multiple modes of protein export.

Sijwali PS, Rosenthal PJ.

PLoS One. 2010 Apr 19;5(4):e10227. doi: 10.1371/journal.pone.0010227.


Characterisation of a delta-COP homologue in the malaria parasite, Plasmodium falciparum.

Adisa A, Rug M, Foley M, Tilley L.

Mol Biochem Parasitol. 2002 Aug 7;123(1):11-21.


The N-terminal segment of Plasmodium falciparum SURFIN4.1 is required for its trafficking to the red blood cell cytosol through the endoplasmic reticulum.

Zhu X, Yahata K, Alexandre JS, Tsuboi T, Kaneko O.

Parasitol Int. 2013 Apr;62(2):215-29. doi: 10.1016/j.parint.2012.12.006. Epub 2012 Dec 31.


Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax.

Sleebs BE, Gazdik M, O'Neill MT, Rajasekaran P, Lopaticki S, Lackovic K, Lowes K, Smith BJ, Cowman AF, Boddey JA.

J Med Chem. 2014 Sep 25;57(18):7644-62. doi: 10.1021/jm500797g. Epub 2014 Sep 11.


Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region.

Gambini L, Rizzi L, Pedretti A, Taglialatela-Scafati O, Carucci M, Pancotti A, Galli C, Read M, Giurisato E, Romeo S, Russo I.

PLoS One. 2015 Nov 13;10(11):e0142509. doi: 10.1371/journal.pone.0142509. eCollection 2015. Erratum in: PLoS One. 2016;11(1):e0146627.

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