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Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair.

Nakamura K, Kogame T, Oshiumi H, Shinohara A, Sumitomo Y, Agama K, Pommier Y, Tsutsui KM, Tsutsui K, Hartsuiker E, Ogi T, Takeda S, Taniguchi Y.

PLoS Genet. 2010 Jan 22;6(1):e1000828. doi: 10.1371/journal.pgen.1000828.


BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination.

Hoa NN, Kobayashi J, Omura M, Hirakawa M, Yang SH, Komatsu K, Paull TT, Takeda S, Sasanuma H.

PLoS One. 2015 Apr 24;10(4):e0124495. doi: 10.1371/journal.pone.0124495. eCollection 2015.


Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

Chen L, Nievera CJ, Lee AY, Wu X.

J Biol Chem. 2008 Mar 21;283(12):7713-20. doi: 10.1074/jbc.M710245200. Epub 2008 Jan 2.


CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle.

Yun MH, Hiom K.

Nature. 2009 May 21;459(7245):460-3. doi: 10.1038/nature07955. Epub 2009 Apr 8.


The role of the Mre11-Rad50-Nbs1 complex in double-strand break repair-facts and myths.

Takeda S, Hoa NN, Sasanuma H.

J Radiat Res. 2016 Aug;57 Suppl 1:i25-i32. doi: 10.1093/jrr/rrw034. Epub 2016 Jun 15.


Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines.

Hoa NN, Akagawa R, Yamasaki T, Hirota K, Sasa K, Natsume T, Kobayashi J, Sakuma T, Yamamoto T, Komatsu K, Kanemaki MT, Pommier Y, Takeda S, Sasanuma H.

Genes Cells. 2015 Dec;20(12):1059-76. doi: 10.1111/gtc.12310. Epub 2015 Nov 2.


CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks.

Wang H, Shao Z, Shi LZ, Hwang PY, Truong LN, Berns MW, Chen DJ, Wu X.

J Biol Chem. 2012 Jun 15;287(25):21471-80. doi: 10.1074/jbc.M112.355354. Epub 2012 Apr 27.


The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.

Reczek CR, Szabolcs M, Stark JM, Ludwig T, Baer R.

J Cell Biol. 2013 May 27;201(5):693-707. doi: 10.1083/jcb.201302145.


The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair.

Wang H, Shi LZ, Wong CC, Han X, Hwang PY, Truong LN, Zhu Q, Shao Z, Chen DJ, Berns MW, Yates JR 3rd, Chen L, Wu X.

PLoS Genet. 2013;9(2):e1003277. doi: 10.1371/journal.pgen.1003277. Epub 2013 Feb 28.


Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

Langerak P, Mejia-Ramirez E, Limbo O, Russell P.

PLoS Genet. 2011 Sep;7(9):e1002271. doi: 10.1371/journal.pgen.1002271. Epub 2011 Sep 8.


MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.

Yuan J, Chen J.

J Biol Chem. 2010 Jan 8;285(2):1097-104. doi: 10.1074/jbc.M109.078436. Epub 2009 Nov 12.


NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes.

Volcic M, Karl S, Baumann B, Salles D, Daniel P, Fulda S, Wiesmüller L.

Nucleic Acids Res. 2012 Jan;40(1):181-95. doi: 10.1093/nar/gkr687. Epub 2011 Sep 9.


CtIP-mediated resection is essential for viability and can operate independently of BRCA1.

Polato F, Callen E, Wong N, Faryabi R, Bunting S, Chen HT, Kozak M, Kruhlak MJ, Reczek CR, Lee WH, Ludwig T, Baer R, Feigenbaum L, Jackson S, Nussenzweig A.

J Exp Med. 2014 Jun 2;211(6):1027-36. doi: 10.1084/jem.20131939. Epub 2014 May 19.


N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair.

Yuan J, Chen J.

J Biol Chem. 2009 Nov 13;284(46):31746-52. doi: 10.1074/jbc.M109.023424. Epub 2009 Sep 16.


CtIP links DNA double-strand break sensing to resection.

You Z, Shi LZ, Zhu Q, Wu P, Zhang YW, Basilio A, Tonnu N, Verma IM, Berns MW, Hunter T.

Mol Cell. 2009 Dec 25;36(6):954-69. doi: 10.1016/j.molcel.2009.12.002.


MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts.

Aparicio T, Baer R, Gottesman M, Gautier J.

J Cell Biol. 2016 Feb 15;212(4):399-408. doi: 10.1083/jcb.201504005.


Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection.

Parameswaran B, Chiang HC, Lu Y, Coates J, Deng CX, Baer R, Lin HK, Li R, Paull TT, Hu Y.

Cell Cycle. 2015;14(3):437-48. doi: 10.4161/15384101.2014.972901.


The complexity of DNA double strand breaks is a critical factor enhancing end-resection.

Yajima H, Fujisawa H, Nakajima NI, Hirakawa H, Jeggo PA, Okayasu R, Fujimori A.

DNA Repair (Amst). 2013 Nov;12(11):936-46. doi: 10.1016/j.dnarep.2013.08.009. Epub 2013 Sep 13.


CtIP is required to initiate replication-dependent interstrand crosslink repair.

Duquette ML, Zhu Q, Taylor ER, Tsay AJ, Shi LZ, Berns MW, McGowan CH.

PLoS Genet. 2012;8(11):e1003050. doi: 10.1371/journal.pgen.1003050. Epub 2012 Nov 8.


Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors.

Lin ZP, Ratner ES, Whicker ME, Lee Y, Sartorelli AC.

Mol Cancer Res. 2014 Mar;12(3):381-93. doi: 10.1158/1541-7786.MCR-13-0480. Epub 2014 Jan 10.

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