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Items: 1 to 20 of 114

1.

T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells.

DeKruyff RH, Bu X, Ballesteros A, Santiago C, Chim YL, Lee HH, Karisola P, Pichavant M, Kaplan GG, Umetsu DT, Freeman GJ, Casasnovas JM.

J Immunol. 2010 Feb 15;184(4):1918-30. doi: 10.4049/jimmunol.0903059. Epub 2010 Jan 18.

2.

TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.

Freeman GJ, Casasnovas JM, Umetsu DT, DeKruyff RH.

Immunol Rev. 2010 May;235(1):172-89. doi: 10.1111/j.0105-2896.2010.00903.x. Review.

3.

TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.

Kobayashi N, Karisola P, Peña-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, Umetsu DT, Dekruyff RH, Freeman GJ.

Immunity. 2007 Dec;27(6):927-40.

4.

TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells.

Albacker LA, Karisola P, Chang YJ, Umetsu SE, Zhou M, Akbari O, Kobayashi N, Baumgarth N, Freeman GJ, Umetsu DT, DeKruyff RH.

J Immunol. 2010 Dec 1;185(11):6839-49. doi: 10.4049/jimmunol.1001360. Epub 2010 Oct 29.

5.

Characterizing functional domains for TIM-mediated enveloped virus entry.

Moller-Tank S, Albritton LM, Rennert PD, Maury W.

J Virol. 2014 Jun;88(12):6702-13. doi: 10.1128/JVI.00300-14. Epub 2014 Apr 2.

6.

Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity.

Lee HH, Meyer EH, Goya S, Pichavant M, Kim HY, Bu X, Umetsu SE, Jones JC, Savage PB, Iwakura Y, Casasnovas JM, Kaplan G, Freeman GJ, DeKruyff RH, Umetsu DT.

J Immunol. 2010 Nov 1;185(9):5225-35. doi: 10.4049/jimmunol.1001116. Epub 2010 Oct 1.

7.

Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry.

Moller-Tank S, Kondratowicz AS, Davey RA, Rennert PD, Maury W.

J Virol. 2013 Aug;87(15):8327-41. doi: 10.1128/JVI.01025-13. Epub 2013 May 22.

8.

T-cell immunoglobulin and mucin domain 1 deficiency eliminates airway hyperreactivity triggered by the recognition of airway cell death.

Kim HY, Chang YJ, Chuang YT, Lee HH, Kasahara DI, Martin T, Hsu JT, Savage PB, Shore SA, Freeman GJ, Dekruyff RH, Umetsu DT.

J Allergy Clin Immunol. 2013 Aug;132(2):414-25.e6. doi: 10.1016/j.jaci.2013.03.025. Epub 2013 May 11.

9.

Characterization of Human and Murine T-Cell Immunoglobulin Mucin Domain 4 (TIM-4) IgV Domain Residues Critical for Ebola Virus Entry.

Rhein BA, Brouillette RB, Schaack GA, Chiorini JA, Maury W.

J Virol. 2016 Jun 10;90(13):6097-111. doi: 10.1128/JVI.00100-16. Print 2016 Jul 1.

PMID:
27122575
10.

Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells.

Suzuki J, Denning DP, Imanishi E, Horvitz HR, Nagata S.

Science. 2013 Jul 26;341(6144):403-6. doi: 10.1126/science.1236758. Epub 2013 Jul 11.

11.

T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice.

Rodriguez-Manzanet R, Sanjuan MA, Wu HY, Quintana FJ, Xiao S, Anderson AC, Weiner HL, Green DR, Kuchroo VK.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8706-11. doi: 10.1073/pnas.0910359107. Epub 2010 Apr 5.

12.

Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation.

Nakayama M, Akiba H, Takeda K, Kojima Y, Hashiguchi M, Azuma M, Yagita H, Okumura K.

Blood. 2009 Apr 16;113(16):3821-30. doi: 10.1182/blood-2008-10-185884. Epub 2009 Feb 17.

13.

Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds.

Santiago C, Ballesteros A, Martínez-Muñoz L, Mellado M, Kaplan GG, Freeman GJ, Casasnovas JM.

Immunity. 2007 Dec;27(6):941-51.

14.

Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine.

Schweigert O, Dewitz C, Möller-Hackbarth K, Trad A, Garbers C, Rose-John S, Scheller J.

Biochim Biophys Acta. 2014 Feb;1843(2):275-87. doi: 10.1016/j.bbamcr.2013.11.014. Epub 2013 Nov 25.

15.

Evidence for carbohydrate recognition and homotypic and heterotypic binding by the TIM family.

Wilker PR, Sedy JR, Grigura V, Murphy TL, Murphy KM.

Int Immunol. 2007 Jun;19(6):763-73. Epub 2007 May 19.

16.

Two-step engulfment of apoptotic cells.

Toda S, Hanayama R, Nagata S.

Mol Cell Biol. 2012 Jan;32(1):118-25. doi: 10.1128/MCB.05993-11. Epub 2011 Oct 28.

17.

The phosphatidylserine receptor TIM-4 does not mediate direct signaling.

Park D, Hochreiter-Hufford A, Ravichandran KS.

Curr Biol. 2009 Feb 24;19(4):346-51. doi: 10.1016/j.cub.2009.01.042. Epub 2009 Feb 12.

18.

Tim4- and MerTK-mediated engulfment of apoptotic cells by mouse resident peritoneal macrophages.

Nishi C, Toda S, Segawa K, Nagata S.

Mol Cell Biol. 2014 Apr;34(8):1512-20. doi: 10.1128/MCB.01394-13. Epub 2014 Feb 10.

19.

Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment.

Kang Y, Zhao D, Liang H, Liu B, Zhang Y, Liu Q, Wang X, Liu Y.

Genes Dev. 2012 Jun 15;26(12):1339-50. doi: 10.1101/gad.187815.112.

20.

The Phosphatidylserine and Phosphatidylethanolamine Receptor CD300a Binds Dengue Virus and Enhances Infection.

Carnec X, Meertens L, Dejarnac O, Perera-Lecoin M, Hafirassou ML, Kitaura J, Ramdasi R, Schwartz O, Amara A.

J Virol. 2015 Oct 14;90(1):92-102. doi: 10.1128/JVI.01849-15.

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