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Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB).

Gray SJ, Blake BL, Criswell HE, Nicolson SC, Samulski RJ, McCown TJ, Li W.

Mol Ther. 2010 Mar;18(3):570-8. doi: 10.1038/mt.2009.292. Epub 2009 Dec 29. Erratum in: Mol Ther. 2010 May;18(5):1054. Li, Wuping [added].


Adeno-associated virus vector-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity.

McCown TJ.

Neurotherapeutics. 2009 Apr;6(2):307-11. doi: 10.1016/j.nurt.2009.01.004. Review.


Adeno-associated virus-mediated expression and constitutive secretion of NPY or NPY13-36 suppresses seizure activity in vivo.

Foti S, Haberman RP, Samulski RJ, McCown TJ.

Gene Ther. 2007 Nov;14(21):1534-6. Epub 2007 Aug 23.


The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5.

Weinberg MS, Blake BL, Samulski RJ, McCown TJ.

Gene Ther. 2011 Oct;18(10):961-8. doi: 10.1038/gt.2011.49. Epub 2011 Apr 14.


Directed evolution of adeno-associated virus (AAV) as vector for muscle gene therapy.

Yang L, Li J, Xiao X.

Methods Mol Biol. 2011;709:127-39. doi: 10.1007/978-1-61737-982-6_8.


Therapeutic liabilities of in vivo viral vector tropism: adeno-associated virus vectors, NMDAR1 antisense, and focal seizure sensitivity.

Haberman R, Criswell H, Snowdy S, Ming Z, Breese G, Samulski R, McCown T.

Mol Ther. 2002 Oct;6(4):495-500.


Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain.

Markakis EA, Vives KP, Bober J, Leichtle S, Leranth C, Beecham J, Elsworth JD, Roth RH, Samulski RJ, Redmond DE Jr.

Mol Ther. 2010 Mar;18(3):588-93. doi: 10.1038/mt.2009.286. Epub 2009 Dec 15.


Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma.

Thorsen F, Afione S, Huszthy PC, Tysnes BB, Svendsen A, Bjerkvig R, Kotin RM, Lønning PE, Hoover F.

J Gene Med. 2006 Sep;8(9):1131-40.


Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates.

Dodiya HB, Bjorklund T, Stansell J 3rd, Mandel RJ, Kirik D, Kordower JH.

Mol Ther. 2010 Mar;18(3):579-87. doi: 10.1038/mt.2009.216. Epub 2009 Sep 22.


Transduction of the central nervous system after intracerebroventricular injection of adeno-associated viral vectors in neonatal and juvenile mice.

Gholizadeh S, Tharmalingam S, Macaldaz ME, Hampson DR.

Hum Gene Ther Methods. 2013 Aug;24(4):205-13. doi: 10.1089/hgtb.2013.076. Epub 2013 Aug 3.


The future of epilepsy treatment: focus on adeno-associated virus vector gene therapy.

McCown TJ.

Drug News Perspect. 2010 Jun;23(5):281-6. doi: 10.1358/dnp.2010.23.5.1468393. Review.


Engineering and evolution of synthetic adeno-associated virus (AAV) gene therapy vectors via DNA family shuffling.

Kienle E, Senís E, Börner K, Niopek D, Wiedtke E, Grosse S, Grimm D.

J Vis Exp. 2012 Apr 2;(62). pii: 3819. doi: 10.3791/3819.


Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development.

Lin EJ, Richichi C, Young D, Baer K, Vezzani A, During MJ.

Eur J Neurosci. 2003 Oct;18(7):2087-92.


Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism.

Powell SK, Khan N, Parker CL, Samulski RJ, Matsushima G, Gray SJ, McCown TJ.

Gene Ther. 2016 Nov;23(11):807-814. doi: 10.1038/gt.2016.62. Epub 2016 Sep 15.


Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion.

Haberman RP, Samulski RJ, McCown TJ.

Nat Med. 2003 Aug;9(8):1076-80. Epub 2003 Jul 13.


Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture.

Vulchanova L, Schuster DJ, Belur LR, Riedl MS, Podetz-Pedersen KM, Kitto KF, Wilcox GL, McIvor RS, Fairbanks CA.

Mol Pain. 2010 May 28;6:31. doi: 10.1186/1744-8069-6-31.


AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity.

Guggenhuber S, Monory K, Lutz B, Klugmann M.

PLoS One. 2010 Dec 21;5(12):e15707. doi: 10.1371/journal.pone.0015707.

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