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Items: 1 to 20 of 120

1.

Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin.

Machutta CA, Bommineni GR, Luckner SR, Kapilashrami K, Ruzsicska B, Simmerling C, Kisker C, Tonge PJ.

J Biol Chem. 2010 Feb 26;285(9):6161-9. doi: 10.1074/jbc.M109.077909. Epub 2009 Dec 16.

2.

Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB.

Schaeffer ML, Agnihotri G, Volker C, Kallender H, Brennan PJ, Lonsdale JT.

J Biol Chem. 2001 Dec 14;276(50):47029-37. Epub 2001 Oct 12.

3.

Substrate recognition by β-ketoacyl-ACP synthases.

Borgaro JG, Chang A, Machutta CA, Zhang X, Tonge PJ.

Biochemistry. 2011 Dec 13;50(49):10678-86. doi: 10.1021/bi201199x. Epub 2011 Nov 17.

4.

Thiolactomycin-based β-ketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy.

Kapilashrami K, Bommineni GR, Machutta CA, Kim P, Lai CT, Simmerling C, Picart F, Tonge PJ.

J Biol Chem. 2013 Mar 1;288(9):6045-52. doi: 10.1074/jbc.M112.414516. Epub 2013 Jan 10.

5.

X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB).

Sridharan S, Wang L, Brown AK, Dover LG, Kremer L, Besra GS, Sacchettini JC.

J Mol Biol. 2007 Feb 16;366(2):469-80. Epub 2006 Nov 7.

6.

Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism.

Price AC, Choi KH, Heath RJ, Li Z, White SW, Rock CO.

J Biol Chem. 2001 Mar 2;276(9):6551-9. Epub 2000 Oct 24.

7.

Development of a scintillation proximity assay for the Mycobacterium tuberculosis KasA and KasB enzymes involved in mycolic acid biosynthesis.

Schaeffer ML, Carson JD, Kallender H, Lonsdale JT.

Tuberculosis (Edinb). 2004;84(6):353-60.

PMID:
15525558
8.
9.

Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis.

Kremer L, Douglas JD, Baulard AR, Morehouse C, Guy MR, Alland D, Dover LG, Lakey JH, Jacobs WR Jr, Brennan PJ, Minnikin DE, Besra GS.

J Biol Chem. 2000 Jun 2;275(22):16857-64.

10.

Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.

Brown AK, Sridharan S, Kremer L, Lindenberg S, Dover LG, Sacchettini JC, Besra GS.

J Biol Chem. 2005 Sep 16;280(37):32539-47. Epub 2005 Jul 22.

11.

Bacterial beta-ketoacyl-acyl carrier protein synthases as targets for antibacterial agents.

Khandekar SS, Daines RA, Lonsdale JT.

Curr Protein Pept Sci. 2003 Feb;4(1):21-9. Review.

PMID:
12570782
12.

Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH).

Khandekar SS, Gentry DR, Van Aller GS, Warren P, Xiang H, Silverman C, Doyle ML, Chambers PA, Konstantinidis AK, Brandt M, Daines RA, Lonsdale JT.

J Biol Chem. 2001 Aug 10;276(32):30024-30. Epub 2001 May 24.

14.

A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli.

Jackowski S, Zhang YM, Price AC, White SW, Rock CO.

Antimicrob Agents Chemother. 2002 May;46(5):1246-52.

15.

Novel inhibitors of the condensing enzymes of the type II fatty acid synthase of pea (Pisum sativum).

Jones AL, Herbert D, Rutter AJ, Dancer JE, Harwood JL.

Biochem J. 2000 Apr 1;347 Pt 1:205-9.

17.
18.

Beta-ketoacyl-acyl carrier protein synthase III from pea (Pisum sativum L.): properties, inhibition by a novel thiolactomycin analogue and isolation of a cDNA clone encoding the enzyme.

Jones AL, Gane AM, Herbert D, Willey DL, Rutter AJ, Kille P, Dancer JE, Harwood JL.

Planta. 2003 Mar;216(5):752-61. Epub 2002 Nov 26.

PMID:
12624762
19.

Development of a scintillation proximity assay for beta-ketoacyl-acyl carrier protein synthase III.

He X, Mueller JP, Reynolds KA.

Anal Biochem. 2000 Jun 15;282(1):107-14.

PMID:
10860506
20.

Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis.

Slayden RA, Lee RE, Armour JW, Cooper AM, Orme IM, Brennan PJ, Besra GS.

Antimicrob Agents Chemother. 1996 Dec;40(12):2813-9.

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