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Items: 1 to 20 of 68

1.

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice.

Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, Masliah E, Dillin A.

Cell. 2009 Dec 11;139(6):1157-69. doi: 10.1016/j.cell.2009.11.014.

2.

Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance.

Gontier G, George C, Chaker Z, Holzenberger M, Aïd S.

J Neurosci. 2015 Aug 19;35(33):11500-13. doi: 10.1523/JNEUROSCI.0343-15.2015.

3.

A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity.

El-Ami T, Moll L, Carvalhal Marques F, Volovik Y, Reuveni H, Cohen E.

Aging Cell. 2014 Feb;13(1):165-74. doi: 10.1111/acel.12171. Epub 2013 Nov 22.

4.

Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection.

Cohen E, Du D, Joyce D, Kapernick EA, Volovik Y, Kelly JW, Dillin A.

Aging Cell. 2010 Apr;9(2):126-34. doi: 10.1111/j.1474-9726.2009.00541.x. Epub 2009 Dec 11.

5.

Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease.

Freude S, Hettich MM, Schumann C, Stöhr O, Koch L, Köhler C, Udelhoven M, Leeser U, Müller M, Kubota N, Kadowaki T, Krone W, Schröder H, Brüning JC, Schubert M.

FASEB J. 2009 Oct;23(10):3315-24. doi: 10.1096/fj.09-132043. Epub 2009 Jun 1.

PMID:
19487308
6.

Central insulin and insulin-like growth factor-1 signaling: implications for diabetes associated dementia.

Zemva J, Schubert M.

Curr Diabetes Rev. 2011 Sep;7(5):356-66. Review.

PMID:
21916834
7.
8.

Reduction in Aβ-induced cell death in the hippocampus of 17β-estradiol-treated female rats is associated with an increase in IGF-I signaling and somatostatinergic tone.

Perianes-Cachero A, Canelles S, Aguado-Llera D, Frago LM, Toledo-Lobo MV, Carrera I, Cacabelos R, Chowen JA, Argente J, Arilla-Ferreiro E, Barrios V.

J Neurochem. 2015 Dec;135(6):1257-71. doi: 10.1111/jnc.13381. Epub 2015 Nov 6.

9.
10.

Opposing activities protect against age-onset proteotoxicity.

Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A.

Science. 2006 Sep 15;313(5793):1604-10. Epub 2006 Aug 10.

11.

Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease.

O'Neill C, Kiely AP, Coakley MF, Manning S, Long-Smith CM.

Biochem Soc Trans. 2012 Aug;40(4):721-7. doi: 10.1042/BST20120080. Review.

PMID:
22817723
12.

Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease.

Stöhr O, Schilbach K, Moll L, Hettich MM, Freude S, Wunderlich FT, Ernst M, Zemva J, Brüning JC, Krone W, Udelhoven M, Schubert M.

Age (Dordr). 2013 Feb;35(1):83-101. doi: 10.1007/s11357-011-9333-2. Epub 2011 Nov 6.

13.

The Alzheimer's disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons.

George C, Gontier G, Lacube P, François JC, Holzenberger M, Aïd S.

Brain. 2017 Jul 1;140(7):2012-2027. doi: 10.1093/brain/awx132.

PMID:
28595357
14.

Beta-amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease.

Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A.

Mol Neurobiol. 2012 Dec;46(3):605-13. doi: 10.1007/s12035-012-8313-6. Epub 2012 Aug 12. Review.

PMID:
22886436
15.

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans.

Barbieri M, Bonafè M, Franceschi C, Paolisso G.

Am J Physiol Endocrinol Metab. 2003 Nov;285(5):E1064-71. Review.

PMID:
14534077
16.

The inhibition of IGF-1 signaling promotes proteostasis by enhancing protein aggregation and deposition.

Moll L, Ben-Gedalya T, Reuveni H, Cohen E.

FASEB J. 2016 Apr;30(4):1656-69. doi: 10.1096/fj.15-281675. Epub 2015 Dec 31.

PMID:
26722006
17.

Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation.

Xu PX, Wang SW, Yu XL, Su YJ, Wang T, Zhou WW, Zhang H, Wang YJ, Liu RT.

Behav Brain Res. 2014 May 1;264:173-80. doi: 10.1016/j.bbr.2014.02.002. Epub 2014 Feb 7.

PMID:
24512768
18.

Changes in the brain and plasma Aβ peptide levels with age and its relationship with cognitive impairment in the APPswe/PS1dE9 mouse model of Alzheimer's disease.

Izco M, Martínez P, Corrales A, Fandos N, García S, Insua D, Montañes M, Pérez-Grijalba V, Rueda N, Vidal V, Martínez-Cué C, Pesini P, Sarasa M.

Neuroscience. 2014 Mar 28;263:269-79. doi: 10.1016/j.neuroscience.2014.01.003. Epub 2014 Jan 18.

PMID:
24447596
19.

Impaired neuronal insulin signaling precedes Aβ42 accumulation in female AβPPsw/PS1ΔE9 mice.

Chua LM, Lim ML, Chong PR, Hu ZP, Cheung NS, Wong BS.

J Alzheimers Dis. 2012;29(4):783-91. doi: 10.3233/JAD-2012-111880.

PMID:
22337827
20.

Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease?

Carro E, Trejo JL, Spuch C, Bohl D, Heard JM, Torres-Aleman I.

Neurobiol Aging. 2006 Nov;27(11):1618-31. Epub 2005 Nov 7.

PMID:
16274856

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