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Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice.

Huang J, Zhang Y, Bersenev A, O'Brien WT, Tong W, Emerson SG, Klein PS.

J Clin Invest. 2009 Dec;119(12):3519-29. doi: 10.1172/JCI40572.


Rapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence.

Luo Y, Li L, Zou P, Wang J, Shao L, Zhou D, Liu L.

Transplantation. 2014 Jan 15;97(1):20-9. doi: 10.1097/TP.0b013e3182a7fcf8.


Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion.

Perry JM, He XC, Sugimura R, Grindley JC, Haug JS, Ding S, Li L.

Genes Dev. 2011 Sep 15;25(18):1928-42. doi: 10.1101/gad.17421911. Epub 2011 Sep 2.


Glycogen synthase kinase-3beta inhibition preserves hematopoietic stem cell activity and inhibits leukemic cell growth.

Holmes T, O'Brien TA, Knight R, Lindeman R, Shen S, Song E, Symonds G, Dolnikov A.

Stem Cells. 2008 May;26(5):1288-97. doi: 10.1634/stemcells.2007-0600. Epub 2008 Mar 6.


Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation.

Campbell TB, Basu S, Hangoc G, Tao W, Broxmeyer HE.

Blood. 2009 Oct 15;114(16):3392-401. doi: 10.1182/blood-2008-12-195214. Epub 2009 Aug 18.


Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation.

Trowbridge JJ, Xenocostas A, Moon RT, Bhatia M.

Nat Med. 2006 Jan;12(1):89-98. Epub 2005 Dec 11.


Sulfatase modifying factor 1-mediated fibroblast growth factor signaling primes hematopoietic multilineage development.

Buono M, Visigalli I, Bergamasco R, Biffi A, Cosma MP.

J Exp Med. 2010 Aug 2;207(8):1647-60. doi: 10.1084/jem.20091022. Epub 2010 Jul 19.


Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion.

Lu J, Sun Y, Nombela-Arrieta C, Du KP, Park SY, Chai L, Walkley C, Luo HR, Silberstein LE.

Exp Hematol. 2012 Apr;40(4):307-17.e3. doi: 10.1016/j.exphem.2011.11.010. Epub 2011 Dec 8.


Identification of a stroma-mediated Wnt/beta-catenin signal promoting self-renewal of hematopoietic stem cells in the stem cell niche.

Kim JA, Kang YJ, Park G, Kim M, Park YO, Kim H, Leem SH, Chu IS, Lee JS, Jho EH, Oh IH.

Stem Cells. 2009 Jun;27(6):1318-29. doi: 10.1002/stem.52.


Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways.

Huang J, Nguyen-McCarty M, Hexner EO, Danet-Desnoyers G, Klein PS.

Nat Med. 2012 Dec;18(12):1778-85. doi: 10.1038/nm.2984. Epub 2012 Nov 11.


Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice.

Chen C, Liu Y, Liu Y, Zheng P.

J Clin Invest. 2010 Nov;120(11):4091-101. doi: 10.1172/JCI43873. Epub 2010 Oct 25. Erratum in: J Clin Invest. 2010 Dec 1;120(12):4583.


GSK-3β inhibition promotes engraftment of ex vivo-expanded hematopoietic stem cells and modulates gene expression.

Ko KH, Holmes T, Palladinetti P, Song E, Nordon R, O'Brien TA, Dolnikov A.

Stem Cells. 2011 Jan;29(1):108-18. doi: 10.1002/stem.551.


Wnt3a protein reduces growth factor-driven expansion of human hematopoietic stem and progenitor cells in serum-free cultures.

Duinhouwer LE, Tüysüz N, Rombouts EW, Ter Borg MN, Mastrobattista E, Spanholtz J, Cornelissen JJ, Ten Berge D, Braakman E.

PLoS One. 2015 Mar 25;10(3):e0119086. doi: 10.1371/journal.pone.0119086. eCollection 2015 Mar 25.


IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice.

Siegemund S, Rigaud S, Conche C, Broaten B, Schaffer L, Westernberg L, Head SR, Sauer K.

Blood. 2015 Apr 30;125(18):2786-97. doi: 10.1182/blood-2014-06-583187. Epub 2015 Mar 18.


mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells.

Chen C, Liu Y, Liu Y, Zheng P.

Sci Signal. 2009 Nov 24;2(98):ra75. doi: 10.1126/scisignal.2000559.


GSK3 Deficiencies in Hematopoietic Stem Cells Initiate Pre-neoplastic State that Is Predictive of Clinical Outcomes of Human Acute Leukemia.

Guezguez B, Almakadi M, Benoit YD, Shapovalova Z, Rahmig S, Fiebig-Comyn A, Casado FL, Tanasijevic B, Bresolin S, Masetti R, Doble BW, Bhatia M.

Cancer Cell. 2016 Jan 11;29(1):61-74. doi: 10.1016/j.ccell.2015.11.012.


Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells.

Bug G, Gül H, Schwarz K, Pfeifer H, Kampfmann M, Zheng X, Beissert T, Boehrer S, Hoelzer D, Ottmann OG, Ruthardt M.

Cancer Res. 2005 Apr 1;65(7):2537-41.


Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.

McCubrey JA, Steelman LS, Bertrand FE, Davis NM, Abrams SL, Montalto G, D'Assoro AB, Libra M, Nicoletti F, Maestro R, Basecke J, Cocco L, Cervello M, Martelli AM.

Leukemia. 2014 Jan;28(1):15-33. doi: 10.1038/leu.2013.184. Epub 2013 Jun 19. Review.


Role of the mammalian target of rapamycin pathway in lentiviral vector transduction of hematopoietic stem cells.

Wang CX, Torbett BE.

Curr Opin Hematol. 2015 Jul;22(4):302-8. doi: 10.1097/MOH.0000000000000150. Review.


Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains.

Ye S, Tan L, Yang R, Fang B, Qu S, Schulze EN, Song H, Ying Q, Li P.

PLoS One. 2012;7(4):e35892. doi: 10.1371/journal.pone.0035892. Epub 2012 Apr 23.

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