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Items: 1 to 20 of 98

1.

Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish.

Dovey M, White RM, Zon LI.

Zebrafish. 2009 Dec;6(4):397-404. doi: 10.1089/zeb.2009.0606.

2.

Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish.

Santoriello C, Gennaro E, Anelli V, Distel M, Kelly A, Köster RW, Hurlstone A, Mione M.

PLoS One. 2010 Dec 10;5(12):e15170. doi: 10.1371/journal.pone.0015170.

3.

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models.

Yen J, White RM, Wedge DC, Van Loo P, de Ridder J, Capper A, Richardson J, Jones D, Raine K, Watson IR, Wu CJ, Cheng J, Martincorena I, Nik-Zainal S, Mudie L, Moreau Y, Marshall J, Ramakrishna M, Tarpey P, Shlien A, Whitmore I, Gamble S, Latimer C, Langdon E, Kaufman C, Dovey M, Taylor A, Menzies A, McLaren S, O'Meara S, Butler A, Teague J, Lister J, Chin L, Campbell P, Adams DJ, Zon LI, Patton EE, Stemple DL, Futreal PA.

Genome Biol. 2013;14(10):R113.

4.

Loss of keratinocytic RXRα combined with activated CDK4 or oncogenic NRAS generates UVB-induced melanomas via loss of p53 and PTEN in the tumor microenvironment.

Coleman DJ, Chagani S, Hyter S, Sherman AM, Löhr CV, Liang X, Ganguli-Indra G, Indra AK.

Mol Cancer Res. 2015 Jan;13(1):186-96. doi: 10.1158/1541-7786.MCR-14-0164. Epub 2014 Sep 4.

5.

Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation.

Anelli V, Santoriello C, Distel M, Köster RW, Ciccarelli FD, Mione M.

Zebrafish. 2009 Dec;6(4):417-24. doi: 10.1089/zeb.2009.0612.

PMID:
20047469
6.

Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas.

Reifenberger J, Knobbe CB, Sterzinger AA, Blaschke B, Schulte KW, Ruzicka T, Reifenberger G.

Int J Cancer. 2004 Apr 10;109(3):377-84.

7.

Oncogenic NRAS has multiple effects on the malignant phenotype of human melanoma cells cultured in vitro.

Eskandarpour M, Huang F, Reeves KA, Clark E, Hansson J.

Int J Cancer. 2009 Jan 1;124(1):16-26. doi: 10.1002/ijc.23876.

8.

BRAF and NRAS mutations in melanoma and melanocytic nevi.

Poynter JN, Elder JT, Fullen DR, Nair RP, Soengas MS, Johnson TM, Redman B, Thomas NE, Gruber SB.

Melanoma Res. 2006 Aug;16(4):267-73.

PMID:
16845322
9.

A high level of liver-specific expression of oncogenic Kras(V12) drives robust liver tumorigenesis in transgenic zebrafish.

Nguyen AT, Emelyanov A, Koh CH, Spitsbergen JM, Lam SH, Mathavan S, Parinov S, Gong Z.

Dis Model Mech. 2011 Nov;4(6):801-13. doi: 10.1242/dmm.007831. Epub 2011 Jul 4.

10.

BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.

Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF, Murphey RD, Berghmans S, Mayhall EA, Traver D, Fletcher CD, Aster JC, Granter SR, Look AT, Lee C, Fisher DE, Zon LI.

Curr Biol. 2005 Feb 8;15(3):249-54.

11.

miR-146a promotes the initiation and progression of melanoma by activating Notch signaling.

Forloni M, Dogra SK, Dong Y, Conte D Jr, Ou J, Zhu LJ, Deng A, Mahalingam M, Green MR, Wajapeyee N.

Elife. 2014 Feb 18;3:e01460. doi: 10.7554/eLife.01460.

12.

The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes.

Yu H, McDaid R, Lee J, Possik P, Li L, Kumar SM, Elder DE, Van Belle P, Gimotty P, Guerra M, Hammond R, Nathanson KL, Dalla Palma M, Herlyn M, Xu X.

Am J Pathol. 2009 Jun;174(6):2367-77. doi: 10.2353/ajpath.2009.081057. Epub 2009 Apr 23.

13.

Marked genetic differences between BRAF and NRAS mutated primary melanomas as revealed by array comparative genomic hybridization.

Lázár V, Ecsedi S, Vízkeleti L, Rákosy Z, Boross G, Szappanos B, Bégány A, Emri G, Adány R, Balázs M.

Melanoma Res. 2012 Jun;22(3):202-14. doi: 10.1097/CMR.0b013e328352dbc8.

PMID:
22456166
14.

Inhibition of melanoma development in the Nras((Q61K)) ::Ink4a(-/-) mouse model by the small molecule BI-69A11.

Feng Y, Lau E, Scortegagna M, Ruller C, De SK, Barile E, Krajewski S, Aza-Blanc P, Williams R, Pinkerton AB, Jackson M, Chin L, Pellecchia M, Bosenberg M, Ronai ZA.

Pigment Cell Melanoma Res. 2013 Jan;26(1):136-42. doi: 10.1111/pcmr.12033. Epub 2012 Nov 2.

15.

Overexpression of PDGFRA cooperates with loss of NF1 and p53 to accelerate the molecular pathogenesis of malignant peripheral nerve sheath tumors.

Ki DH, He S, Rodig S, Look AT.

Oncogene. 2017 Feb 23;36(8):1058-1068. doi: 10.1038/onc.2016.269. Epub 2016 Aug 1.

16.

A mouse model of melanoma driven by oncogenic KRAS.

Milagre C, Dhomen N, Geyer FC, Hayward R, Lambros M, Reis-Filho JS, Marais R.

Cancer Res. 2010 Jul 1;70(13):5549-57. doi: 10.1158/0008-5472.CAN-09-4254. Epub 2010 Jun 1.

17.

Generating and analyzing fish models of melanoma.

Patton EE, Mathers ME, Schartl M.

Methods Cell Biol. 2011;105:339-66. doi: 10.1016/B978-0-12-381320-6.00014-X.

PMID:
21951537
18.
19.

Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma.

Burd CE, Liu W, Huynh MV, Waqas MA, Gillahan JE, Clark KS, Fu K, Martin BL, Jeck WR, Souroullas GP, Darr DB, Zedek DC, Miley MJ, Baguley BC, Campbell SL, Sharpless NE.

Cancer Discov. 2014 Dec;4(12):1418-29. doi: 10.1158/2159-8290.CD-14-0729. Epub 2014 Sep 24.

20.

Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis.

Ferguson B, Konrad Muller H, Handoko HY, Khosrotehrani K, Beermann F, Hacker E, Soyer HP, Bosenberg M, Walker GJ.

Pigment Cell Melanoma Res. 2010 Dec;23(6):771-80. doi: 10.1111/j.1755-148X.2010.00752.x. Epub 2010 Sep 1.

PMID:
20718941

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