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The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior.

Ziemann AE, Allen JE, Dahdaleh NS, Drebot II, Coryell MW, Wunsch AM, Lynch CM, Faraci FM, Howard MA 3rd, Welsh MJ, Wemmie JA.

Cell. 2009 Nov 25;139(5):1012-21. doi: 10.1016/j.cell.2009.10.029.


The bed nucleus of the stria terminalis is critical for anxiety-related behavior evoked by CO2 and acidosis.

Taugher RJ, Lu Y, Wang Y, Kreple CJ, Ghobbeh A, Fan R, Sowers LP, Wemmie JA.

J Neurosci. 2014 Jul 30;34(31):10247-55. doi: 10.1523/JNEUROSCI.1680-14.2014.


An acid-sensing channel sows fear and panic.

Maren S.

Cell. 2009 Nov 25;139(5):867-9. doi: 10.1016/j.cell.2009.11.008.


Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior.

Wemmie JA, Coryell MW, Askwith CC, Lamani E, Leonard AS, Sigmund CD, Welsh MJ.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3621-6. Epub 2004 Feb 26.


Restoring Acid-sensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses.

Coryell MW, Wunsch AM, Haenfler JM, Allen JE, McBride JL, Davidson BL, Wemmie JA.

J Neurosci. 2008 Dec 17;28(51):13738-41. doi: 10.1523/JNEUROSCI.3907-08.2008.


Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior.

Coryell MW, Wunsch AM, Haenfler JM, Allen JE, Schnizler M, Ziemann AE, Cook MN, Dunning JP, Price MP, Rainier JD, Liu Z, Light AR, Langbehn DR, Wemmie JA.

J Neurosci. 2009 Apr 29;29(17):5381-8. doi: 10.1523/JNEUROSCI.0360-09.2009.


Seizure termination by acidosis depends on ASIC1a.

Ziemann AE, Schnizler MK, Albert GW, Severson MA, Howard MA 3rd, Welsh MJ, Wemmie JA.

Nat Neurosci. 2008 Jul;11(7):816-22. doi: 10.1038/nn.2132. Epub 2008 Jun 8.


Heteromeric acid-sensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal death.

Sherwood TW, Lee KG, Gormley MG, Askwith CC.

J Neurosci. 2011 Jun 29;31(26):9723-34. doi: 10.1523/JNEUROSCI.1665-11.2011.


N-glycosylation of acid-sensing ion channel 1a regulates its trafficking and acidosis-induced spine remodeling.

Jing L, Chu XP, Jiang YQ, Collier DM, Wang B, Jiang Q, Snyder PM, Zha XM.

J Neurosci. 2012 Mar 21;32(12):4080-91. doi: 10.1523/JNEUROSCI.5021-11.2012.


Targeting ASIC1a reduces innate fear and alters neuronal activity in the fear circuit.

Coryell MW, Ziemann AE, Westmoreland PJ, Haenfler JM, Kurjakovic Z, Zha XM, Price M, Schnizler MK, Wemmie JA.

Biol Psychiatry. 2007 Nov 15;62(10):1140-8. Epub 2007 Jul 30.


Dynorphin opioid peptides enhance acid-sensing ion channel 1a activity and acidosis-induced neuronal death.

Sherwood TW, Askwith CC.

J Neurosci. 2009 Nov 11;29(45):14371-80. doi: 10.1523/JNEUROSCI.2186-09.2009.


Role of acidosis, NMDA receptors, and acid-sensitive ion channel 1a (ASIC1a) in neuronal death induced by ischemia.

Isaev NK, Stelmashook EV, Plotnikov EY, Khryapenkova TG, Lozier ER, Doludin YV, Silachev DN, Zorov DB.

Biochemistry (Mosc). 2008 Nov;73(11):1171-5. Review.


The human ortholog of acid-sensing ion channel gene ASIC1a is associated with panic disorder and amygdala structure and function.

Smoller JW, Gallagher PJ, Duncan LE, McGrath LM, Haddad SA, Holmes AJ, Wolf AB, Hilker S, Block SR, Weill S, Young S, Choi EY, Rosenbaum JF, Biederman J, Faraone SV, Roffman JL, Manfro GG, Blaya C, Hirshfeld-Becker DR, Stein MB, Van Ameringen M, Tolin DF, Otto MW, Pollack MH, Simon NM, Buckner RL, Ong├╝r D, Cohen BM.

Biol Psychiatry. 2014 Dec 1;76(11):902-10. doi: 10.1016/j.biopsych.2013.12.018. Epub 2014 Jan 18.


Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a.

Sherwood TW, Askwith CC.

J Biol Chem. 2008 Jan 25;283(4):1818-30. Epub 2007 Nov 5.


ASIC1a activation enhances inhibition in the basolateral amygdala and reduces anxiety.

Pidoplichko VI, Aroniadou-Anderjaska V, Prager EM, Figueiredo TH, Almeida-Suhett CP, Miller SL, Braga MF.

J Neurosci. 2014 Feb 26;34(9):3130-41. doi: 10.1523/JNEUROSCI.4009-13.2014.


Acid-sensing ion channels interact with and inhibit BK K+ channels.

Petroff EY, Price MP, Snitsarev V, Gong H, Korovkina V, Abboud FM, Welsh MJ.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3140-4. doi: 10.1073/pnas.0712280105. Epub 2008 Feb 14.


Seizure termination by acidosis depends on ASIC1a.

McKhann GM 2nd.

Neurosurgery. 2008 Oct;63(4):N10. doi: 10.1227/01.NEU.0000339453.48345.4C. No abstract available.


Expression of acid-sensing ion channels in intestinal epithelial cells and their role in the regulation of duodenal mucosal bicarbonate secretion.

Dong X, Ko KH, Chow J, Tuo B, Barrett KE, Dong H.

Acta Physiol (Oxf). 2011 Jan;201(1):97-107. doi: 10.1111/j.1748-1716.2010.02207.x. Epub 2010 Nov 12.


Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.

Duan B, Wang YZ, Yang T, Chu XP, Yu Y, Huang Y, Cao H, Hansen J, Simon RP, Zhu MX, Xiong ZG, Xu TL.

J Neurosci. 2011 Feb 9;31(6):2101-12. doi: 10.1523/JNEUROSCI.4351-10.2011.


ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory.

Chiang PH, Chien TC, Chen CC, Yanagawa Y, Lien CC.

Sci Rep. 2015 May 19;5:10143. doi: 10.1038/srep10143.

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